Regular ArticleAluminium Lactate Treatment of DQ12 Quartz Inhibits Its Ability to Cause Inflammation, Chemokine Expression, and Nuclear Factor-κB Activation
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An in vitro assessment of the toxicity of two-dimensional synthetic and natural layered silicates
2022, Toxicology in VitroCitation Excerpt :No ROS generation was observed in DQ12-exposed J774A.1 cells, where the level remained constant, irrespective of time and concentration studied. This result was highly unexpected as it has been shown that crystalline silica can induce on its surface, formation of silicon-based free radicals, which in aqueous suspensions generate ROS, including H2O2, ·OH and O2•¯ (Fubini and Hubbard, 2003; Shi et al., 1998; Donaldson and Borm, 1998; Duffin et al., 2001). Moreover, crystalline silica is a potent stimulant of the respiratory burst in phagocytic cells which leads to ROS/RNS production (Zhang et al., 2010; van Berlo et al., 2010).
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2020, Toxicology and Applied PharmacologyThe effect of aluminium and sodium impurities on the in vitro toxicity and pro-inflammatory potential of cristobalite
2017, Environmental ResearchCitation Excerpt :Elements incorporated structurally will be present at the surface of the particle, as well as internally. Al treatment of the quartz surface decreases its cytotoxic potency, ability to induce inflammatory indicators, and its haemolytic potency (Duffin et al., 2001; Nolan et al., 1981). It has been suggested that an Al treatment would bind to silanols (a surface functional group with the connectivity Si–O–H) on the silica surface, replacing H+ and, thereby, prevent the adsorption of cell membrane components to the silica surface (Fubini, 1998).