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Biofuels pp 147–177Cite as

Metabolic Engineering for Pentose Utilization in Saccharomyces cerevisiae

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Part of the book series: Advances in Biochemical Engineering/Biotechnology ((ABE,volume 108))

Abstract

The introduction of pentose utilization pathways in baker's yeast Saccharomyces cerevisiae is summarized together with metabolic engineering strategies to improve ethanolic pentose fermentation. Bacterial and fungal xylose and arabinose pathways have been expressed in S. cerevisiae but do not generally convey significant ethanolic fermentation traits to this yeast. A large number of rational metabolic engineering strategies directed among others toward sugar transport, initial pentose conversion, the pentose phosphate pathway, and the cellular redox metabolism have been exploited. The directed metabolic engineering approach has often been combined with random approaches including adaptation, mutagenesis, and hybridization. The knowledge gained about pentose fermentation in S. cerevisiae is primarily limited to genetically and physiologically well-characterized laboratory strains. The translation of this knowledge to strains performing in an industrial context is discussed.

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Authors and Affiliations

  1. Applied Microbiology, Lund University, P.O. Box 124, 221 00, Lund, Sweden

    Bärbel Hahn-Hägerdal, Kaisa Karhumaa, Marie Jeppsson & Marie F. Gorwa-Grauslund

  2. GS Development AB, Jägershillgatan 15, 213 75, Malmö, Sweden

    Marie Jeppsson

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  1. Bärbel Hahn-Hägerdal
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  2. Kaisa Karhumaa
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  3. Marie Jeppsson
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  4. Marie F. Gorwa-Grauslund
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Correspondence to Bärbel Hahn-Hägerdal .

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Hahn-Hägerdal, B., Karhumaa, K., Jeppsson, M., Gorwa-Grauslund, M.F. (2007). Metabolic Engineering for Pentose Utilization in Saccharomyces cerevisiae . In: Olsson, L. (eds) Biofuels. Advances in Biochemical Engineering/Biotechnology, vol 108. Springer, Berlin, Heidelberg. https://doi.org/10.1007/10_2007_062

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