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Developmental Regulation of the β-Globin Gene Locus

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Book cover Epigenetics and Chromatin

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 38))

Abstract

The β-globin genes have become a classical model for studying regulation of gene expression. Wide-ranging studies have revealed multiple levels of epigenetic regulation that coordinately ensure a highly specialised, tissue- and stage-specific gene transcription pattern. Key players include cis-acting elements involved in establishing and maintaining specific chromatin conformations and histone modification patterns, elements engaged in the transcription process through long-range regulatory interactions, trans-acting general and tissue-specific factors. On a larger scale, molecular events occurring at the locus level take place in the context of a highly dynamic nucleus as part of the cellular epigenetic programme.

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  1. Laboratory of Chromatin and Gene Expression, The Babraham Institute, Cambridge, CB2 4AT, UK

    Lyubomira Chakalova, David Carter, Emmanuel Debrand, Beatriz Goyenechea, Alice Horton, Joanne Miles, Cameron Osborne & Peter Fraser

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  1. Lyubomira Chakalova
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  2. David Carter
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  3. Emmanuel Debrand
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  4. Beatriz Goyenechea
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  5. Alice Horton
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  6. Joanne Miles
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  7. Cameron Osborne
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  8. Peter Fraser
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  1. Institute of Molecular Genetics of Montpellier, 1919 Route de Mende, 34293, Montpellier Cedex 05, France

    Philippe Jeanteur

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© 2005 Springer-Verlag Berlin Heidelberg

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Chakalova, L. et al. (2005). Developmental Regulation of the β-Globin Gene Locus. In: Jeanteur, P. (eds) Epigenetics and Chromatin. Progress in Molecular and Subcellular Biology, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-27310-7_8

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