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Behavioral Neurobiology of Schizophrenia and Its Treatment pp 529–553Cite as

Hippocampal Pathology in Schizophrenia

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Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 4))

Abstract

The hippocampus is abnormal in schizophrenia. Smaller hippocampal volume is the most consistent finding and is present already in the early stages of the illness. The underlying cellular substrate is a subtle, yet functionally significant reduction of hippocampal interneurons. Neuroimaging studies have revealed a pattern of increased hippocampal activity at baseline and decreased recruitment during the performance of memory tasks. Hippocampal lesion models in rodents have replicated some of the pharmacological, anatomical and behavioral phenotype of schizophrenia. Taken together, this pattern of findings points to a disinhibition of hippocampal pyramidal cells and abnormal cortico-hippocampal interactions in schizophrenia.

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Authors and Affiliations

  1. Department of Psychiatry, Vanderbilt University, 1601 23rd Avenue South, Room 3060, Nashville, TN, 37212, USA

    Stephan Heckers

  2. Department of Pharmacology, Vanderbilt University, 1601 23rd Avenue South, Room 3060, Nashville, TN, 37212, USA

    Christine Konradi

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    Neal R. Swerdlow

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Heckers, S., Konradi, C. (2010). Hippocampal Pathology in Schizophrenia. In: Swerdlow, N. (eds) Behavioral Neurobiology of Schizophrenia and Its Treatment. Current Topics in Behavioral Neurosciences, vol 4. Springer, Berlin, Heidelberg. https://doi.org/10.1007/7854_2010_43

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