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Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins

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Book cover Target Pattern Recognition in Innate Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 653))

Abstract

Innate immunity comprises a sophisticated network of molecules, which recognize pathogens, and effector molecules, working together to establish a quick and efficient immune response to infectious agents. Complement activation triggered by mannan binding lectin (MBL) or ficolins represents a beautiful example of this network. Both MBL and ficolins recognize specific chemical structures on the surface of antigens and pathogens, thus bind to a broad variety of pathogens. Once bound further complement deposition is achieved through a cascade of proteolytic reactions. MBL and ficolin induced complement activation is critical for adequate anti-bacterial, anti-fungal and anti-viral responses. This is well illustrated by numerous and convincing studies that demonstrate associations between MBL deficiency and infections. Recent work has also highlighted that MBL and ficolins recognize self-structures, thus extending the role of these molecules beyond the traditional view of first line defense molecules. It appears that MBL deficiency may modulate the prognosis of inflammatory and autoimmune diseases. What is known about the mechanisms behind this broad scope of activities of MBL and ficolins is discussed in this chapter.

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Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark

    Steffen Thiel

  2. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 77 Louis Pasteur Avenue, NRB Room 652, Boston, MA, 02115, USA

    Mihaela Gadjeva

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  1. Steffen Thiel
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  2. Mihaela Gadjeva
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Editors and Affiliations

  1. Laboratory of Human Immunology and Infection Biology, Biosciences Division, School of Health Sciences and Social Care, Brunei University, Uxbridge, London, UK

    Uday Kishore PhD

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© 2009 Landes Bioscience and Springer Science+Business Media

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Thiel, S., Gadjeva, M. (2009). Humoral Pattern Recognition Molecules: Mannan-Binding Lectin and Ficolins. In: Kishore, U. (eds) Target Pattern Recognition in Innate Immunity. Advances in Experimental Medicine and Biology, vol 653. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0901-5_5

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