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Epigenetic Deregulation in Rheumatoid Arthritis

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Book cover Epigenetic Contributions in Autoimmune Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 711))

Abstract

In this chapter, we discuss the current understanding of the possible epigenetics changes that occur in rheumatoid arthritis. In particular, we describe that deregulation of DNA methylation and histone modifications can occur in the immune system and lead to rheumatoid arthritis. In addition, we discuss the role of rheumatoid arthritis synovial fibroblasts in autoimmunity. Examples of changes in DNA methylation and histone modification occurring in synovial fibroblasts during the disease process are reviewed in this chapter. In conclusion, we discuss the possible use of epigenetic therapy and describe future experiments that can elucidate further the epigenetic changes observed in the disease.

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Author information

Authors and Affiliations

  1. Center for Experimental Rheumatology, University Hospital Zurich, Gloriastrasse, Zurich, Switzerland

    Emmanuel Karouzakis, Renate E. Gay, Steffen Gay & Michel Neidhart

Authors
  1. Emmanuel Karouzakis
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  2. Renate E. Gay
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  3. Steffen Gay
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  4. Michel Neidhart
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Editors and Affiliations

  1. Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Esteban Ballestar PhD

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Karouzakis, E., Gay, R.E., Gay, S., Neidhart, M. (2011). Epigenetic Deregulation in Rheumatoid Arthritis. In: Ballestar, E. (eds) Epigenetic Contributions in Autoimmune Disease. Advances in Experimental Medicine and Biology, vol 711. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-8216-2_10

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