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The Confounding Effect of Systemic Physiology on the Hemodynamic Response in Newborns

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Oxygen Transport to Tissue XXXIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 737))

Abstract

In preterm newborns, evoked hemoglobin responses often show inversed patterns when compared to patterns observed in adults. We suspect that changes in hematocrit during the transition from fetal to adult hemoglobin and the consequent period of low hematocrit cause such an inversion. To test this assumption, we performed a longitudinal auditory functional study in six premature neonates with a total of 18 recording sessions. Using near-infrared spectroscopy (NIRS), we measured both local (de)oxy-hemoglobin changes during auditory stimulation with a continuous-wave (CW-NIRS) system and baseline absolute (de)oxy-hemoglobin concentrations with a frequency domain (FD-NIRS) system. Our results show that the inversion in the functional hemodynamic responses in infants correlates with the total hemoglobin concentration. These results suggest that the available hemoglobin supply during the low hematocrit period is not sufficient to overcome oxygen demand during functional activation.

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Acknowledgments

The authors thank all the families for their participation and the nurses, physicians, and staff in the Neonatal ICU, Special Care Nursery, Pediatric Neurology, and maternity units at the Massachusetts General Hospital. This work is supported by NIH grant R01 HD42908.

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Authors and Affiliations

  1. Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, MA, 02129, USA

    B. B. Zimmermann, N. Roche-Labarbe, A. Surova, D. A. Boas & M. A. Franceschini

  2. Biomedical Optics Research Laboratory, Clinic for Neonatology, University Hospital Zürich, Zürich, Switzerland

    B. B. Zimmermann & M. Wolf

  3. Newborn Medicine and Radiology, Children’s Hospital of Boston, Boston, MA, USA

    P. E. Grant

Authors
  1. B. B. Zimmermann
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  2. N. Roche-Labarbe
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  3. A. Surova
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  4. D. A. Boas
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  5. M. Wolf
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  6. P. E. Grant
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  7. M. A. Franceschini
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Corresponding author

Correspondence to B. B. Zimmermann .

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Editors and Affiliations

  1. , Division of Neonatology, University Hospital Zurich, Frauenklinikstr. 10, Zurich, 8091, Switzerland

    Martin Wolf

  2. , Division of Neonatology, University Hospital Zurich, Frauenklinikstr. 10, Zurich, 8091, Switzerland

    Hans Ulrich Bucher

  3. Institute for Biomedical Engineering, University of Zurich/ETHZ, Wolfgang-Pauli-Strasse 27, Zurich, 8093, Switzerland

    Markus Rudin

  4. ESAT-SCD(SISTA), Dept. Elektrotechniek, Katholieke Universiteit Leuven, Kasteelpark Arenberg 10, Leuven-Heverlee, 3001, Belgium

    Sabine Van Huffel

  5. , Institute of Complementary Medicine KIKO, University of Bern, Imhoof-Pavillon, Inselspital, Bern, 3010, Switzerland

    Ursula Wolf

  6. Synthesizer Inc., Synthesizer Inc. 2773, Ellicott City, 21043, Maryland, USA

    Duane F. Bruley

  7. , Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, NE1 7RU, United Kingdom

    David K Harrison

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Zimmermann, B.B. et al. (2012). The Confounding Effect of Systemic Physiology on the Hemodynamic Response in Newborns. In: Wolf, M., et al. Oxygen Transport to Tissue XXXIII. Advances in Experimental Medicine and Biology, vol 737. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1566-4_16

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