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Sensing Endoplasmic Reticulum Stress

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Self and Nonself

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 738))

Abstract

This chapter provides an overview of our present understanding of mechanisms of sensing protein folding status and endoplasmic reticulum (ER) stress in eukaryotic cells. The ER folds and matures most secretory and transmembrane proteins. Mis- or unfolded proteins are sensed by specialized ER stress sensors, such as IRE1, PERK and ATF6, which initiate several cellular responses and signaling pathways to restore ER homeostasis. These intracellular signaling events are called the unfolded protein response (UPR). Here we focus on how ER stress and protein folding status in the ER are sensed by the ER stress sensors by summarizing results from recent structural, biochemical and genetic approaches.

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  1. School of Biological and Biomedical Sciences, Durham University, Durham, UK

    Vipul M. Parmar & Martin Schröder

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  2. Martin Schröder
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Correspondence to Martin Schröder .

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  1. Department of Immunology, Hospital Universitario Central de Asturias, Oviedo, Spain

    Carlos López-Larrea PhD

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Parmar, V.M., Schröder, M. (2012). Sensing Endoplasmic Reticulum Stress. In: López-Larrea, C. (eds) Self and Nonself. Advances in Experimental Medicine and Biology, vol 738. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-1680-7_10

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