Abstract
Tissue viability and function are often manifest in hemodynamic signatures, because metabolism and vascular regulatory mechanisms modulate the concentration, oxygenation and flow characteristics of blood cells. Assessment of tissue viability and function from hemodynamic measures can be complicated however, by the interplay between vascular supply, tissue oxygen consumption and regulatory effects. It is therefore desirable to independently monitor hemoglobin concentration, oxygenation and flow. In this contribution we present diffuse optical measurements of hemoglobin concentration, oxygenation and flow during global modulations in rat brain, through the intact skull.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ances, B.M., Wilson, D.F., Greenberg, J.H. and Detre, J.A., Dynamic changes in cerebral blood flow, O-2 tension, and calculated cerebral metabolic rate of O-2 during functional activation using oxygen phosphorescence quenching, Journal of Cerebral Blood Flow and Metabolism, 21 (2001) 511–516.
Benaron, D.A., Hintz, S.R., Villringer, A., Boas, D., Kleinschmidt, A., Frahm, J., Hirth, C., Obrig, H., van Houten, J.C., Kermit, E.L., Cheong, W.F. and Stevenson, D.K., Noninvasive functional imaging of human brain using light, Journal of Cerebral Blood Flow and Metabolism, 20 (2000) 469–477.
Cheung, C., Culver, J.P., Yodh, A.G., Takahashi, K. and Greenberg, J.H., In vivo cerebrovascular measurement combining diffuse near-infrared absorption and correlation spectroscopies, Physics in Medicine and Biology, 46 (2001) 2053–2065.
Danen, R.M., Wang, Y., Li, X.D., Thayer, W.S. and Yodh, A.G., Regional imager for low-resolution functional imaging of the brain with diffusing near-infrared light, Photochemistry and Photobiology, 67 (1998) 33–40.
Haskell, R.C., Svaasand, L.O., Tsay, T.T., Feng, T.C. and McAdams, M.S., Boundary-Conditions For the Diffusion Equation in Radiative- Transfer, Journal of the Optical Society of America a-Optics Image Science and Vision, 11 (1994) 2727–2741.
Mandeville, J.B., Marota, J.J.A., Ayata, C., Moskowitz, M.A., Weisskoff, R.M. and Rosen, B.R., MRI measurement of the temporal evolution of relative CMRO2 during rat forepaw stimulation, Magnetic Resonance in Medicine, 42 (1999) 944–951.
Mayhew, J., Johnston, D., Berwick, J., Jones, M., Coffey, P. and Zheng, Y., Spectroscopic analysis of neural activity in brain: Increased oxygen consumption following activation of barrel cortex, Neuroimage, 12 (2000) 664–675.
Villringer, A. and Chance, B., Non-invasive optical spectroscopy and imaging of human brain function, Trends in Neurosciences, 20 (1997) 435–442.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this chapter
Cite this chapter
Culver, J.P., Durduran, T., Cheung, C., Yodh, A.G., Furuya, D., Greenberg, J.H. (2003). Diffuse Optical Measurement of Hemoglobin and Cerebral Blood Flow in Rat Brain During Hypercapnia, Hypoxia and Cardiac Arrest. In: Wilson, D.F., Evans, S.M., Biaglow, J., Pastuszko, A. (eds) Oxygen Transport To Tissue XXIII. Advances in Experimental Medicine and Biology, vol 510. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0205-0_48
Download citation
DOI: https://doi.org/10.1007/978-1-4615-0205-0_48
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-4964-8
Online ISBN: 978-1-4615-0205-0
eBook Packages: Springer Book Archive