Abstract
Interleukin 11 (IL-11) is a pleiotropic cytokine initially identified as a factor stimulating proliferation of IL-6-dependet murine plasmacytoma cell line T11651. Today IL-11 is known to interact with variety of haematopoietic and nonhematopoietic cell types (for review see ref. 2). Many of the biological effects of IL-11 are shared with IL-6 since both cytokines share a common receptor subunit ß (gp 130).
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References
Paul SR, Bennett F, Calvetti JA, Kelleher K, Wood CR, O’Hara RM Jr, Leary AC, Sibley B, Clark SC, Williams DA, YangYC, 1990, Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.Proc Natl Acad Sci USA.87:7512–6.
Du X, Williams DA, 1997, Interleukin-11: review of molecular, cell biology, and clinical use.Blood.89:3897–908.
Mackiewicz A, Koj A, Sehgal PB, 1995, Interleukin-6-type cytokines.Ann NY Acad Sci.762.
Katz A, Shulman LM, Porgador A, Revel M, Feldman M, Eisenbach L, 1993, Abrogation of B16 melanoma metastases by long-term low-dose interleukin-6 therapy.J Immunother.13:98–109.
Porgador A, Tzehoval E, Katz A, Vadai E, Revel M, Feldman M, Eisenbach L, 1992, Interleukin 6 gene transfection into Lewis lung carcinoma tumor cells suppresses the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells.Cancer Res.52:3679–86.
Mackiewicz A, Wiznerowicz M, Roeb E, Karczewska A, Nowak J, Heinrich PC, Rose-John S, 1995, Soluble interleukin 6 receptor is biologically active in vivo.Cytokine.7:142–9.
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© 2001 Springer Science+Business Media New York
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Dams-Kozlowska, H., Izycki, D., Mackiewicz, a. (2001). IL-11 is a potent anti-melanoma factor. In: Mackiewicz, A., Kurpisz, M., Żeromski, J. (eds) Progress in Basic and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 495. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0685-0_54
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DOI: https://doi.org/10.1007/978-1-4615-0685-0_54
Publisher Name: Springer, Boston, MA
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