Abstract
It is only in the last five years that significant interest has developed in detailing the autoimmune destruction of the salivary and lacrimal tissues in the non-obese diabetic (NOD) mouse. Pioneering studies have demonstrated that the lymphocytic infiltration of the salivary and lacrimal glands correlates with a functional decline in saliva flow and tear production, respectively, that is not attributable to the loss of blood glucose regulation in NOD mice.1,2 Together, these studies indicate that the NOD mouse represents the first-described animal model for the spontaneous, autoimmune-induced loss of both tear production and saliva flow, and is, therefore, emerging as an excellent animal model for the study of human Sjögren’s syndrome.
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References
Humphreys-Beher MG, Hu Y, Nakagawa Y, Wang PL, Purushotham KR. Utilization of the non-obese diabetic mouse as an animal model for the study of secondary Sjögren’s syndrome. Adv Exp Med Biol. 1994; 350: 631–636.
Hu Y, Nakagawa Y, Purushotham KR, Humphreys-Beher MG. Functional changes in the salivary glands of autoimmune NOD mice. Am JPhysiol. 1992; 263: E607–E614.
Fox P, Speight P. Current concepts in autoimmune exocrinopathy: immunologic mechanisms in the salivary pathology of Sjögren’s Syndrome. Crit Rev Oral Biol Med. 1996; 7: 144–158.
Fox P, Speight P. Current concepts in autoimmune exocrinopathy: immunologic mechanisms in the salivary pathology of Sjögren’s Syndrome. Crit Rev Oral Biol Med. 1996; 7: 144–158.
Ballas Z, Rasmussen W. Lymphokine activated killer (LAK) cells. Cell Immunol. 1991; 134: 296–313.
Zhou T, Bluethmann H, Eldridge J, Bery K, Mountz J. Origin of CD4–CD8-B220+ T cells in MRL-Ipr/Ipr mice. Clues from a T cell receptor beta transgenic mouse. J Immunol. 1993; 150: 3651–3657.
Rabinovitch A, Saurez-Pinzon W, Sorenson O, Bleakley R, Power R. IFN-gamma gene expression in pancreatic islet-infiltrating mononuclear cells correlates with autoimmune diabetes. J Immunol. 1995; 154: 4874–4882.
Rabinovitch A, Saurez-Pinzon W, Sorenson O, Bleackley R. Inducible nitric oxide synthase in pancreatic islets of NOD mice: identification of iNOS expressing cells and relationships to cytokines expressed in these islets. Endocrinolology. 1996; 137: 2093–2099.
Yang X, McDevitt H. Role of TNF-alpha in the development of autoimmunity and the pathogenesis of insulin dependent diabetes in NOD mice. Circ Shock. 1994; 43: 995–1004.
Welsh M, Welsh N, Bendtzen K. Comparison of mRNA contents of IL-10 and nitric oxide synthase in pancreatic islets isolated from male and female NOD mice. Diabetologia. 1995; 38: 153–160.
Sarvetnick N, Shizuru J, Liggitt D. Loss of pancreatic tolerance induced by Beta cell expression of IFN gamma. Nature. 1993; 346: 844–847.
Wu A, Chen ZJ, Tsokos M. Interferon gamma induced cell death in a cultured human salivary gland cell line. J Cell Physiol. 1996; 167: 297–304.
Hamono H, Saito I, Haneji N. Expression of cytokine genes during development of sialadenitis in MRL/Ipr mice. EurJ lmmunol. 1993; 23: 2387–2391.
Skarstein K, Holmdahl R, Johannessen AC, Jonsson R. Characterization of the T cell receptor repertoire and anti-Ro/SS-A autoantibodies in relation to sialoadenitis in NOD mice. Immunol. 1993; 83: 497–501.
Robinson C, Yamamoto H, Peck A, Humphreys-Beher M. Genetically programmed development of salivary gland abnormalities in autoimmune NOD mice. Clin Immunol Immunopathol. 1996; 79: 50–59.
Cutler L, Rozenski D, Coolens J. Experimental autoallergic sialadenitis in the LEW rat. Cell Immunol. 1991; 135: 335–345.
Dang H, Geiser A, Letterio J. SLE-like autoantibodies and Sjögren’s Syndrome-like lymphoproliferation in TGF-B knockout mice. J Immunol. 1995; 155: 3205–3212.
Strasser A, Whittingham S, Vaux D. Enforced bcl-2 expression in B-lymphoid cells prolongs antibody responses and elicit autoimmune disease. Proc Natl Acad Sci USA. 1993; 88: 8661–8665.
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Robinson, C.P., Cornelius, J., Bounous, D.I., Yamamoto, H., Humphreys-Beher, M.G., Peck, A.B. (1998). Infiltrating Lymphocyte Populations and Cytokine Production in the Salivary and Lacrimal Glands of Autoimmune NOD Mice. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_68
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_68
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