Abstract
There is a misconception in some oncology circles that low-grade tumors are not likely to be controlled by clinically feasible radiation doses. This is so despite the abundant data that radiation alone achieves a high probability of permanent and complete responses of basal cell carcinomas of the skin, well-differentiated squamous cell carcinoma of the glottis, etc. Patients are not as concerned about the rate of response as about the probability that the response will ultimately be complete and permanent. The evidence available is that the low-grade soft tissue sarcomas respond as well as the high-grade ones. However, the difference between the low- and the high-grade sarcomas is that for low-grade sarcomas the time to achieve an observable response may be long. In this chapter we consider the response of fibromatosis and dermatofibrosarcoma protuberans (DFSP) to radiation alone or combined with surgery.
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References
McAnena OJ, Daly JM. Desmoid fibrosarcoma; Gardner’s syndrome. In JH Raaf, ed. Soft Tissue Sarcomas. Diagnosis and Treatment. St. Louis, MO: CV Mosby, 1993:151.
McAnena OJ, Daly JM. Desmoid fibrosarcoma; Gardner’s syndrome. In JH Raaf, ed. Soft Tissue Sarcomas. Diagnosis and Treatment. St. Louis, MO: CV Mosby, 1993:153.
Jarvinen HJ. Desmoid disease as a part of the familial adenomatous Polyposis coli. Acta Chir Scand 153:379–383, 1987.
Russell WO, Cohen J, Enzinger F, Hajdu SI, Heise H, Martin RG, Meissner W, Miller WT, Schmitz RL, Suit HD. A clinical and pathological staging system for soft tissue sarcomas. Cancer 40:1562–1570, 1977.
Posner MC, Shiu MH, Newsome JL, Hajdu SI, Gaynor JJ, Brennan MF. The fibromatoses. Arch Surg 124:191–196, 1989.
Weiss SW. Histological Typing of Soft Tissue Tumours, 2nd ed. Berlin: Springer-Verlag, 1994.
McCollough WM, Parsons JT, van der Griend R, Enneking WF, Heare T. Radiation therapy for aggressive fibromatosis: The experience at the University of Florida. J Bone Joint Surg 73A:717–725.
Rock MG, Pritchard DJ, Reiman HM, Soule EH, Brewster RC. Extra-abdominal fibromatosis. J Bone Joint Surg 66A:1369–1374, 1984.
Faulkner LB, Hajdu SI, Kher U, LaQuaglia M, Exelby PR, Heller G, Wollner N. Pediatric desmoid tumor: Retrospective analysis of 63 cases. J Clin Oncol 13:2813–2818, 1995.
Catton CN, O’Sullivan B, Bell R, Cummings B, Fornasier V, Panzarella T. Aggressive fibromatosis: Optimisation of local management with a retrospective failure analysis. Radiother Oncol 34:17–22, 1995.
Reitamo JJ, Scheinin TM, Hayry P. The fibromatosis syndrome: New aspects in the cause, pathogenesis and treatment of the fibromatosis. Am J Surg 151:230–237, 1986.
Karakousis CP, Mayordomo J, Zografos GC, Driscoll DL. Desmoid tumors of the trunk and extremity. Cancer 72:1637–1641, 1993.
Spear M, Jennings LC, Efird JT, Mankin HJ, Springfield DS, Gebhardt MC, Spiro IJ, Rosenberg AE, Suit HD. Radiation therapy and surgery in the treatment of fibromatosis. Unpublished data.
Keus R, Bartelink H. The role of radiotherapy in the treatment of fibromatosis. Radiother Oncol 7:1–5, 1986.
Patel SR, Evans HL, Benjamin RS. Combination chemotherapy in adult desmoid tumors. Cancer 72:3244–3247, 1993.
Kinzbrunner B, Ritter S, Domingo J, Rosenthal CJ. Remission of rapidly growing desmoid tumors after tamoxifen therapy. Cancer 52:2201–2204, 1983.
Waddell WR, Gerner RE, Reich MP. Non-sterioid anti-inflammatory drugs and tamoxifen for desmoid tumors and carcinoma of the stomach. J Surg Oncol 22:197–211, 1983.
Gaskill HV, Aust JB. Dermatofibrosarcoma protuberans; fibromatosis of the hands and feet; pseudosarcomatous lesions. In JH Raaf, ed. Soft Tissue Sarcomas. Diagnosis and Treatment. St. Louis, MO: CV Mosby, 1993:101.
Enzinger FM, Weiss SW. Soft Tissue Tumors, 2nd ed. St. Louis, MO: CV Mosby, 1988:252.
Rutgers EJG, Kroon BBR, Albus-Lutter CE, Gortzak E. Dermatofibrosarcoma protuberans: Treatment and prognosis. Eur J Surg Oncol 18:241–248, 1992.
Connelly JH, Evans HL. Dermatofibrosarcoma protuberans. A clinicopathologic review with emphasis on fibrosarcomatous areas. Am J Surg Pathol 161:921–925, 1992.
Pedeutour F, Simon MP, Minoletti F, Sozzi G, Pierotti MA, Hecht F, Turc-Carel C. Ring 22 chromosomes in dermatofibro-sarcoma protuberans are low-level amplifiers of chromosome 17 and 22 sequences. Cancer Res 55:2400–2403, 1995.
Allan AE, Tsou HC, Harrington A, Stasko T, Lee X, Si SP, Grande DJ, Peacocke M. Clonal origin of dermatofibrosarcoma protuberans. J Invest Dermatol 100:99–102, 1993.
Jimenez FJ, Grichnik JM, Buchanan MD, Clark RE. Immunohistochemical margin control applied to Mohs micrographic surgical excision of dermatofibrosarcoma protuberans. J Dermatol Surg Oncol 20:687–689, 1994.
Goldblum JR. CD34 positivity in fibrosarcomas which arise in dematofibrosarcoma protuberans. Arch Pathol Lab Med 119:238–324, 1995.
Smola MG, Soyer HP, Scharnagl E. Surgical treatment of dermatofibrosarcoma protuberans. A retrospective study of 20 cases with review of literature. Eur J Surg Oncol 17:447–453, 1991.
Bendix-Hansen K, Myhre-Jensen O, Kaae S. Dermatofibro-sarcoma Protuberans. A clinico-pathological study of nineteen cases and review of world literature. Scand J Plast Reconstr Surg 17:247–252, 1983.
Parker TL, Zitelli JA. Surgical margins for excision of dermatofibrosarcoma protuberans. J Am Acad Dermatol 32:233–236, 1995.
Mark RJ, Bailet JW, Tran LM, Poen J, Fu YS, Calcaterra TC. Dermatofibrosarcoma protuberans of the head and neck. Arch Otolaryngol Head Neck Surg 119:891–896, 1993.
O’Sullivan G, Catton C, Bell R, Fornasier V, Gullane P, Cummings B, Quirt I, Wunder J. Treatment outcome in dermatofibrosarcoma protuberans referred to a radiation oncology practice. Int J Radiat Oncol Biol Phys 32(S1):289, 1995.
Greenberg HM, Goebel R, Weischselbaum RR, Greenberger JS, Chaffey JT, Cassady JR. Radiation therapy in the treatment of aggressive fibromatoses. Int J Radiat Oncol Biol Phys 7:305–310, 1981.
Leibel SA, Wara WM, Hill DR, et al. Desmoid tumors: Local control and patterns of relapse following radiation therapy. Int J Radiat Oncol Biol Phys 9:1167–1171, 1983.
Stockdale AD, Cassoni AM, Coe MA, et al. Radiotherapy and conservative surgery in the management of musculo-aponeurotic fibromatosis. Int J Radiat Oncol Biol Phys 15:851–857, 1988.
Bataini JP, Belloir C, Mazabraud A, Pilleron PP, Cartigny A, Jaulerry C, Ghossein NA. Desmoid tumors in adults: The role of radiotherapy in their management. Am J Surg 155:754–760, 1988.
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Suit, H.D., Spiro, I.J., Spear, M. (1997). Benign and low-grade tumors of the soft tissues: Role for radiation therapy. In: Verweij, J., Pinedo, H.M., Suit, H.D. (eds) Soft Tissue Sarcomas: Present Achievements and Future Prospects. Cancer Treatment and Research, vol 91. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-6121-7_7
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DOI: https://doi.org/10.1007/978-1-4615-6121-7_7
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