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Label-Free Detection with the Liquid Core Optical Ring Resonator Sensing Platform

  • Protocol
Book cover Biosensors and Biodetection

Part of the book series: Methods in Molecular Biology™ ((MIMB,volume 503))

Summary

Optical label-free detection prevents the cost and complexity of fluorescence and radio labeling while providing accurate quantitative and kinetic results. We have developed a new optical label-free sensor called the liquid core optical ring resonator (LCORR). The LCORR integrates optical ring resonator sensors into the microfluidic delivery system by using glass capillaries with a thin wall. The LCORR is capable of performing refractive index detection on liquid samples, as well as bio/chemical analyte detection down to detection limits on the scale of pg/mm2 on a sensing surface.

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Author information

Authors and Affiliations

  1. Biological Engineering Department, University of Missouri-Columbia, Columbia, MO, USA

    Ian M. White, Hongying Zhu, Jonathan D. Suter & Xudong Fan

  2. Biosensors Division, Biophage Pharma, Montreal, QC, Canada

    Mohammed Zourob

Authors
  1. Ian M. White
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  2. Hongying Zhu
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  3. Jonathan D. Suter
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  4. Xudong Fan
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  5. Mohammed Zourob
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Editor information

Editors and Affiliations

  1. FDA Center for Devices and Radiological Health, Silver Spring, MD, USA

    Avraham Rasooly

  2. National Cancer Institute, Bethesda, MD, USA

    Avraham Rasooly

  3. Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA

    Keith E. Herold

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© 2009 Springer Science+Business Media, LLC

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White, I.M., Zhu, H., Suter, J.D., Fan, X., Zourob, M. (2009). Label-Free Detection with the Liquid Core Optical Ring Resonator Sensing Platform. In: Rasooly, A., Herold, K.E. (eds) Biosensors and Biodetection. Methods in Molecular Biology™, vol 503. Humana Press. https://doi.org/10.1007/978-1-60327-567-5_7

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  • DOI: https://doi.org/10.1007/978-1-60327-567-5_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-60327-566-8

  • Online ISBN: 978-1-60327-567-5

  • eBook Packages: Springer Protocols

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