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Template-Based Protein Structure Modeling

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Book cover Computational Biology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 673))

Abstract

Functional characterization of a protein is often facilitated by its 3D structure. However, the fraction of experimentally known 3D models is currently less than 1% due to the inherently time-consuming and complicated nature of structure determination techniques. Computational approaches are employed to bridge the gap between the number of known sequences and that of 3D models. Template-based protein structure modeling techniques rely on the study of principles that dictate the 3D structure of natural proteins from the theory of evolution viewpoint. Strategies for template-based structure modeling will be discussed with a focus on comparative modeling, by reviewing techniques available for all the major steps involved in the comparative modeling pipeline.

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Acknowledgments

This review is partially based on our previous publications (1, 144).

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  1. Department of Systems and Computational Biology & Department for Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA

    Andras Fiser

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  1. Andras Fiser
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  1. The Rockefeller University, York Avenue 1230, New York, 10065, New York, USA

    David Fenyö

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Fiser, A. (2010). Template-Based Protein Structure Modeling. In: Fenyö, D. (eds) Computational Biology. Methods in Molecular Biology, vol 673. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-842-3_6

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  • DOI: https://doi.org/10.1007/978-1-60761-842-3_6

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