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Spermatogenesis in Cryptorchidism

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Germline Development

Part of the book series: Methods in Molecular Biology ((MIMB,volume 825))

Abstract

Cryptorchidism or undescended testis is the most frequent congenital abnormality in newborn boys. The process of testicular descent to the scrotum is controlled by hormones produced in Leydig cells, insulin-like3, and androgens. Variation in genetic and environmental factors might affect testicular descent. A failure of spermatogenesis and germ cell apoptosis resulting in infertility as well as an increased risk of neoplastic transformation of germ cell are the direct consequences of cryptorchidism in adulthood.

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Acknowledgments

The work in Dr. Agoulnik laboratory is supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development/National Institute of Health grant R01HD37067.

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Authors and Affiliations

  1. Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA

    Alexander I. Agoulnik, Zaohua Huang & Lydia Ferguson

Authors
  1. Alexander I. Agoulnik
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  2. Zaohua Huang
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  3. Lydia Ferguson
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Corresponding author

Correspondence to Alexander I. Agoulnik .

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Editors and Affiliations

  1. , School of Biomedical Sciences, The Chinese University of Hong Kong, n/a, Shatin, New Territories, n/a, Hong Kong/PR China

    Wai-Yee Chan

  2. , Animal Biosciences, ARS-USDA, Baltimore Avenue 10300, Beltsville, 20705, Maryland, USA

    Le Ann Blomberg

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Agoulnik, A.I., Huang, Z., Ferguson, L. (2012). Spermatogenesis in Cryptorchidism. In: Chan, WY., Blomberg, L. (eds) Germline Development. Methods in Molecular Biology, vol 825. Springer, New York, NY. https://doi.org/10.1007/978-1-61779-436-0_11

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  • DOI: https://doi.org/10.1007/978-1-61779-436-0_11

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-61779-435-3

  • Online ISBN: 978-1-61779-436-0

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