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Designing Vaccines for Pandemic Influenza

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Book cover Vaccines for Pandemic Influenza

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 333))

Abstract

Recent outbreaks of highly pathogenic avian influenza A virus infections (including those of the H5N1 subtype) in poultry and in humans (through contact with infected birds) have raised concerns that a new influenza pandemic will soon occur. Effective vaccines against H5N1 virus are therefore urgently needed. Reverse genetics-based inactivated vaccines have been prepared according to WHO recommendations and licensed in several countries following their assessment in clinical trials. However, the effectiveness of these vaccines in a pandemic is not guaranteed. We must therefore continue to develop alternative pandemic vaccine strategies. Here, we review the current strategies for the development of H5N1 influenza vaccines, as well as some future directions for vaccine development.

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Acknowledgments

We thank Susan Watson for editing the manuscript. We also thank those in our laboratories who contributed to the data cited in this review. Our original research was supported by National Institute of Allergy and Infectious Diseases Public Health Service research grants; by CREST (Japan Science and Technology Agency); by Grants-in-Aid for Specially Promoted Research and for Scientific Research (B); by a Contract Research Fund for Program of Founding Research Centers for Emerging and Reemerging Infectious Diseases; and by the Special Coordination Funds for Promoting Science and Technology from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

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Authors and Affiliations

  1. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Taisuke Horimoto & Yoshihiro Kawaoka

  2. International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108–8639, Japan

    Yoshihiro Kawaoka

  3. Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, 53706, USA

    Yoshihiro Kawaoka

Authors
  1. Taisuke Horimoto
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  2. Yoshihiro Kawaoka
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Correspondence to Yoshihiro Kawaoka .

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Editors and Affiliations

  1. School of Medicine, Emory University, Atlanta, 30322, U.S.A.

    Richard W. Compans

  2. School of Medicine, Emory University, Clifton Road 1510, Atlanta, 30322, U.S.A.

    Walter A. Orenstein

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© 2009 Springer-Verlag Berlin Heidelberg

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Horimoto, T., Kawaoka, Y. (2009). Designing Vaccines for Pandemic Influenza. In: Compans, R., Orenstein, W. (eds) Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology, vol 333. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92165-3_8

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