Abstract
Shigella, Gram-negative bacteria closely related to Escherichia coli, are highly adapted human pathogens that cause bacillary dysentery. Although Shigella have neither adherence factors nor flagella required for attaching or accessing the intestinal epithelium, Shigella are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During Shigella infection, they deliver many numbers of effectors through the type III secretion system into the surrounding space and directly into the host-cell cytoplasm. The effectors play pivotal roles from the onset of bacterial infection through to the establishment of the colonization of the intestinal epithelium, such as bacterial invasion, intracellular survival, subversion of the host immune defense response, and maintenance of the infectious foothold. These examples suggest that Shigella have evolved highly sophisticated infectious and intracellular strategies to establish replicative niches in the intestinal epithelium.
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Acknowledgements
We thank the members of the Sasakawa Laboratory for their helpful advice. This work was supported by Grand-in-Aid for Scientific Research (S) (20229006) and (B) (20390123); a Grant-in-Aid for Exploratory Research (20659067); a Grant-in-Aid for Scientific Research on Priority Areas (18073003); the Strategic Cooperation to Control Emerging and Reemerging Infections Funded by The Special Coordination Funds for Promoting Science and Technology; and a Contract Research Fund for the Program of Funding Research Centers for Emerging and Reemerging Infectious Diseases from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), and the Core Research for Evolutional Science and Technology (CREST) from the Japan Science and Technology Agency (JST). The authors have no conflicting financial interests.
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Ashida, H., Ogawa, M., Mimuro, H., Sasakawa, C. (2009). Shigella Infection of Intestinal Epithelium and Circumvention of the Host Innate Defense System. In: Sasakawa, C. (eds) Molecular Mechanisms of Bacterial Infection via the Gut. Current Topics in Microbiology and Immunology, vol 337. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01846-6_8
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