Abstract
During development, cells differentiate into diverse cell types with different sizes. The size of intracellular organelles often correlates with the size of the cell, which may be important for cell homeostasis. The nucleus is a well-known example of an organelle whose size correlates with cell size. However, the mechanical basis of the correlation is unknown. The lengths of the mitotic spindle and contractile ring are emerging as model system to investigate the cell-size-dependent control mechanisms of organelle size. Mechanistic models are proposed for the cell-size-dependent control of these organelles. Understanding the cell-size dependency of organelle sizes is expected to impact not only on the morphogenesis of the individual organelle, but also on cell homeostasis, cell cycle progression, and cell differentiation.
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Acknowledgments
We thank Yukinobu Arata for his advice, Ritsuya Niwayama, Kenji Kimura, Takeshi Sugawara, and Hiroshi Koyama for reading the manuscript. This work was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology (Japan) (to Y.H. and A.K.), the Transdisciplinary Research Integration Center of the Research Organization of Information and Systems (to A.K.), and by a Fellowship from the Japan Society for the Promotion of Science (to Y.H.).
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Hara, Y., Kimura, A. (2011). Cell-Size-Dependent Control of Organelle Sizes During Development. In: Kubiak, J. (eds) Cell Cycle in Development. Results and Problems in Cell Differentiation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19065-0_5
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DOI: https://doi.org/10.1007/978-3-642-19065-0_5
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