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Pathogenesis of Marek’s Disease Virus Infection

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Marek’s Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 255))

Abstract

The term pathogenesis is most simply defined as the development of disease. Many uncomplicated infectious diseases proceed in a direct fashion from infection to a specific pathologic expression. However, other diseases are relatively complex in terms of pathogenesis; Marek’s disease (MD) most certainly belongs in this category. This chapter will concern itself with the spectrum of sequential events triggered by infection with MD virus (MDV), and the consequences of those events at both the cellular and host level. It will also consider the many factors that affect the potential manifestations of MD. Attention will be given to mechanisms and interactions associated with those factors. Major emphasis will be placed on the lymphomagenic nature of the disease.

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  1. Unit of Avian Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, 14853, USA

    B. W. Calnek

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  1. Department of Tumor Virology, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, 113-8510, Tokyo, Japan

    Kanji Hirai

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Calnek, B.W. (2001). Pathogenesis of Marek’s Disease Virus Infection. In: Hirai, K. (eds) Marek’s Disease. Current Topics in Microbiology and Immunology, vol 255. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-56863-3_2

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  • DOI: https://doi.org/10.1007/978-3-642-56863-3_2

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