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Cholesterol Binding and Cholesterol Transport Proteins: pp 47–75Cite as

Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders

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Part of the book series: Subcellular Biochemistry ((SCBI,volume 51))

Abstract

The complex association of cholesterol metabolism and Alzheimer’s disease is presented in depth, including the possible benefits to be gained from cholesterol-lowering statin therapy. Then follows a survey of the role of neuronal membrane cholesterol in Aβ pore formation and Aβ fibrillogenesis, together with the link with membrane raft domains and gangliosides. The contribution of structural studies to Aβ fibrillogenesis, using TEM and AFM, is given some emphasis. The role of apolipoprotein E and its isoforms, in particular ApoE4, in cholesterol and Aβ binding is presented, in relation to genetic risk factors for Alzheimer’s disease. Increasing evidence suggests that cholesterol oxidation products are of importance in generation of Alzheimer’s disease, possibly induced by Aβ-produced hydrogen peroxide. The body of evidence for a link between cholesterol in atherosclerosis and Alzheimer’s disease is increasing, along with an associated inflammatory response. The possible role of cholesterol in tau fibrillization, tauopathies and in some other non-Aβ amyloidogenic disorders is surveyed.

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Abbreviations

AD:

Alzheimer’s disease

Aβ:

Amyloid-beta

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Authors and Affiliations

  1. Institute of Zoology, University of Mainz, D-55099, Mainz, Germany

    J. Robin Harris

  2. Department of Human and Health Sciences, School of Life Sciences, University of Westminster, London, W1W 6UW, UK

    Nathaniel G.N. Milton

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  2. Nathaniel G.N. Milton
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Correspondence to J. Robin Harris .

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    J. Robin Harris

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Harris, J.R., Milton, N.G. (2010). Cholesterol in Alzheimer’s Disease and other Amyloidogenic Disorders. In: Harris, J. (eds) Cholesterol Binding and Cholesterol Transport Proteins:. Subcellular Biochemistry, vol 51. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8622-8_2

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