Abstract
1167 workers of Lorraine (France) iron mines, a random sample of 5600 workers aged 35 to 55 years, at work in 1975 constituted the initial cohort that was examined twice at 5-year intervals after the first examination. A questionnaire on respiratory symptoms and smoking habits (MRC questionnaire) plus questions on the work history of each participant was completed, vital capacity (VC), forced expiratory volume in one second (FEV1.0), residual volume (RV) and fractional uptake of CO (FuCO) were measured at the first examination and repeated five and ten years later. At the end of the ten year follow-up, 522 subjects were re-examined, 186 were lost to follow-up, 328 answered a mail questionnaire, and 111 had died. The total number of deaths was not different from that of the general population, but for lung cancer the standardized mortality ratio (SMR) was significantly increased (SMR = 3.7). For the miners re-examined, frequency of bronchitis and decrease of functional tests were more related to age and smoking habits than to occupation.
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References
American Thoracic Society (1962): Definitions and classification of chronic bronchitis, asthma and pulmonary emphysema - Am. Rev. Resp. Dis. 85: 762–768.
Ames R.G., Attfield M.D., Hankinson J.L., Hearl F.J. and Reger R.B. (1982): Acute respiratory effects of exposure to diesel emissions in coal miners - Am. Rev. Respir. Dis. 125: 139–142.
Ames R.G., Reger R.B. and Hall D.S. (1984): Chronic respiratory effects of exposure to diesel emissions in coal mines - Arch. Environ Health 39: 389–394.
Archer V.E. and Gillam J.D. (1978): Chronic sulfur dioxide exposure in a smelter. II. Indices of chest disease - J. Occup. Med. 20: 88–95.
Axelson O. (1989): Confounding from smoking in occupational epidemiology - Br. J. Ind. Med. 46:505–507.
Bates D., Pham Q.T., Chau N., Pivoteau C., Dechoux J. and Sadoul P. (1985): A longitudinal study of pulmonary function in coal miners in Lorraine. France - Am. J. Ind. Med. 8: 21–32.
Bertrand J.P., Chau N., Patris A., Mur J.M., Pham Q.T., Moulin J.J., Auburtin G., Figueredo A. and Martin J.M. (1987): Mortality due to respiratory cancer in the coke oven plants of the Lorraine coalmining industry - Br. J. Ind. Med. 44: 559–565.
Breslow N.E. and Day N.E. (1987): Statistical methods in cancer research. Vol. II. The design and analysis of cohort studies - Lyon - IARC.
CECA (1971): Aide mémoire pour la pratique de la fonction ventilatoire par la spirographie - Collection d'Hygiène et de Médecine du Travail, n° 11 - 2e ed. -Luxembourg.
Daniel Moussard H., Martin J.C. and LeBouffant L. (1970): Etude expérimentale de faction des vapeurs nitreuses sur le poumon empoussiéré - Poumon 26: 905–912.
Fisher E.B. Jr., Haire-Joshu D., Morgan G.D., Rehberg H. and Rost K. (1990): Smoking and smoking cessation - State of the Art - Am. Rev. Respir. Dis. 142: 702–720.
Fleming G.M., Chester E.H. and Montenegro H.D. (1979): Dysfunction of small airways following pulmonary injury due to nitrogen dioxide - Chest. 75: 720–721.
Friedman G.D., Siegelaub A.B. and Setter C.C. (1973): Cigarette smoking and exposure to occupational hazards - Am. J. Epidemiol. 98: 175–183.
Gamble J., Jones W. and Minshall S. (1987): Epidemiological environmental study of diesel bus garage workers: acute effects of NO2 and respirable particulate on the respiratory system - Environ Res. 42: 201–214.
Gamble J., JonesW. and MinshallS. (1987): Epidemiological environmental study of diesel bus garage workers: chronic effects of diesel exhaust on the respiratory system - Environ Res. 44: 6–17.
Hammond E.C. (1965): Evidence on the effects of giving up cigarette smoking - Am. J. Publ. Health 55: 682–691.
Harkonen H., Nordman H., Korhonen O. and Winblad I. (1983): Long-term effects of exposure to sulfur dioxide - Am. Rev. Respir. Dis. 28: 890–893.
Johnson A., Chan-Yeung M., Maclean L., Atkins E., Dybuncio A. and Enarson D. (1985): Respiratory abnormalities among workers in an iron and steel foundry - Br. J. Ind. Med. 42: 94–100.
Jorgensen H.S., Kolmodin-Hedman B. and Stjernberg N. (1988): Follow-.up study of pulmonary function and respiratory tract symptoms in workers in a Swedish iron ore mine - J. Occup. Med. 30: 953–958.
Lebowitz M.D. (1977): Smoking habits and changes in smoking habits related to chronic conditions and respiratory symptoms - Am. J. Epidemiol. 105: 534–543.
Linn W.S., Jones M.P., Bailey R.M., Kleinman M.T., Spier C.E., Fisher D.A. and Hackney J.D. (1980): Respiratory effects of mixed nitrogen dioxide and sulfur dioxide in human volunteers under simulated ambient exposure conditions - Environ Res. 22: 431–438.
Mastrangelo G., Chau N. and Pham Q.T. (1980): Les différents modes d'expression du test au monoxyde de carbone en régime stable: discussion et proposition de valeurs de référence pour les études épidémiologiques - Respiration 30: 28–38.
Mur J.M., Meyer-Bisch C., Pham Q.T., Massin N., Moulin J.J., Cavelier C. and Sadoul P. (1987): Risk of lung cancer among iron ore miners: a proportional mortality study of 1075 deceased miners in Lorraine -France - J. Occup. Med. 9: 762–767.
Ostlin P. (1988): Negative health selection into physically light occupations - J. Epidemiol. Comm. Health 42: 152–156.
Pairon J.C., Brochard P. Jaur and M.C. and Bignon J. (1991): Silica and lung cancer: a controversial issue -Eur. Respir. J. 4: 730–744.
Perks W.H., Burge P.S., Rehahn M. and Green M. (1979): Work-related respiratory diseases in employees leaving an electronic factory - Thorax 34: 19–25.
Pham Q.T., Gaertner M., Mur J.M., Braun P., Gabiano M. and Sadoul P. (1983): Incidence of lung cancer among iron miners - Eur. J. Respir. Dis. 64: 534–540.
Pham Q.T., Mastrangelo G., Chau N., Haluszka J. (1979): Five year longitudinal comparison of respiratory symptoms and function in steel workers and unexposed workers - Bull. Europ. Physio-Path. Resp. 15: 469–480.
Pham Q.T., Mur J.M., TeculescuD., ChauN., GabianoM., GaertnerM. and HenquelJ.C. (1986): A longitudinal study of symptoms and respiratory function tests in iron miners - Eur. J. Respir. Dis. 69: 346–354.
Rom W.N., Wood S.D., White G.L., Bang K.M. and Reading J.C. (1986): Longitudinal evaluation of pulmonary function in copper smelter workers exposed to sulfur dioxide - Am. Rev. Respir. Dis. 133: 830–833.
Wen C.P., Tsai S.P. and Gibson R.L. (1983): Anatomy of the healthy worker effect, a critical review - J. Occup. Med. 25: 283–289.
Wiester M.J., Iltis R. and Moore W. (1980): Altered function and histology in guinea pigs after inhalation of diesel exhaust - Environ Res. 22: 285–294.
Wong O., Rockette H.E., Redmond C.R. and Heid M. (1978): Evaluation of multiple causes of death in occupational mortality studies - J. Chron. Dis. 31: 183–194.
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Pham, Q.T., Teculescu, D., Bruant, A. et al. Iron miners — A ten year follow-up. Eur J Epidemiol 8, 594–600 (1992). https://doi.org/10.1007/BF00146382
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DOI: https://doi.org/10.1007/BF00146382