Abstract
Tumours consisting of a mixture of mature adipose and smooth muscle tissues, including those designated lipoleiomyomas, fibrolipoleiomyomas and myolipomas, are exceedingly rare, but most often occur in the uterine corpus. We describe here a case of such a tumour arising in the right round ligament of a 44-year-old woman. The tumour, which measured approximately 20×15×10 cm, was well encapsulated and did not involve the intrapelvic organs. Intricate mixtures of adult adipose tissue and bland smooth muscle exhibited no cellular atypia or nuclear mitotic figures, and there was little vascular proliferation. We diagnosed the lesion as a myolipoma of soft tissue with dual differentiation, and have found only 13 cases of this tumour including our own in the English literature. The present tumour is the first reported in the round ligament. Although this tumour is rare, its recognition is important for the avoidance of erroneous diagnoses.
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References
Azumi N, Curtis J, Kempson RL, Hendrickson MR (1987) Atypical and malignant neoplasms showing lipomatous differentiation. A study of 111 cases. Am J Surg Pathol 11:161–183
Brandfass RT, Everts-Suarez EA (1955) Lipomatous tumors of the uterus. A review of the world's literature with report of a case of true lipoma. Am J Obstet Gynecol 70:359–367
Brescia RJ, Tazelaar HD, Hobbs J, Miller AW (1989) Intravascular lipoleiomyomatosis. A report of two cases. Hum Pathol 20:252–256
Brooks JJ, Wells GB, Yeh IT, LiVolsi VA (1992) Bizarre epithelioid lipoleiomyoma of the uterus. Int J Gynecol Pathol 11:144–149
Capt LB, Neubecker RD (1962) Tumors of the round ligament. A review of the literature and a report of 25 cases. Obstet Gynecol 19:771–780
Enzinger FM, Weiss SW (1995) Benign lipomatous tumors and liposarcoma. In: Soft tissue tumors, 3rd edn. Mosby, St. Louis, pp 381–463
Evans HL (1990) Smooth muscle in atypical lipomatous tumors. A report of three cases. Am J Surg Pathol 14:714–718
Gupta AK, Gupta K, Gupta MK (1988) Lipoleiomyoma of uterus (report of three cases). Indian J Cancer 25:104–107
Havel G, Wedell B, Dahlenfor R, Mark J (1989) Cytogenetic relationship between uterine lipoleiomyomas and typical leiomyomas. Virchows Archiv [B] 57:77–79
Honoré LH (1978) Uterine fibrolipoleiomyoma. Report of a case with discussion of histogenesis. Am J Obstet Gynecol 132:635–636
Hu J, Surti U, Tobon H (1992) Cytogenetic analysis of a uterine lipoleiomyoma. Cancer Genet Cytogenet 62:200–202
Hurban RH, Bhagavan BS, Epstein JI (1989) Massive retroperitoneal angiomyolipoma. A lesion that may be confused with well-differentiated liposarcoma. Am J Clin Pathol 92:805–808
Jacobs DS, Cohen H, Johnson JS (1965) Lipoleiomyomas of the uterus. Am J Clin Pathol 44:45–51
Meis JM, Enzinger FM (1991) Myolipoma of soft tissue. Am J Surg Pathol 15:121–125
Michal M (1994) Retroperitoneal myolipoma. A tumour mimicking retroperitoneal angiomyolipoma and liposarcoma with myosarcomatous differentiation. Histopathology 25:86–88
Mira JL (1991) Lipoleiomyoma of the ovary. Report of a case and review of the English literature. Int J Gynecol Pathol 10:198–202
Nuovo MA, Nuovo GJ, Smith D, Lewis SH (1990) Benign mesenchyma of the round ligament. A report of two cases with immunohistochemistry. Am J Clin Pathol 93:421–424
Pounder DJ (1982) Fatty tumours of the uterus. J Clin Pathol 35:1380–1383
Scully RE, Kurman RJ, Silvergerg SG, Wilkinson EJ (1994) Histological typing of female genital tract tumours. In: Word Health Organization international histological classification of tumours, 2nd edn. Springer, Berlin Heidelberg New York, pp 19–21
Scurry J, Hack M (1990) Leiomyosarcoma arising in a lipoleiomyoma. Gynecol Oncol 39:381–383
Scurry JP, Carey MP, Targett CS, Dowling JP (1991) Soft tissue lipoleiomyoma. Pathology 23:360–362
Sieiñski W (1989) Lipomatous neometaplasia of the uterus. Report of 11 cases with discussion of histogenesis and pathogenesis. Int J Gynecol Pathol 8:357–363
Volpe R, Canzonieri V, Gloghini A, Carbone A (1992) “Lipoleiomyoma with metaplastic cartilage” (benign mesenchymoma) of the uterine cervix. Pathol Res Pract 188:799–801
Willén R, Gad A, Willén H (1978) Lipomatous lesions of the uterus. Virchows Archiv [A] 377:351–361
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Sonobe, H., Ohtsuki, Y., Iwata, J. et al. Myolipoma of the round ligament: report of a case with a review of the English literature. Vichows Archiv A Pathol Anat 427, 455–458 (1995). https://doi.org/10.1007/BF00199397
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DOI: https://doi.org/10.1007/BF00199397