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Aberrant breakpoints in chronic myelogenous leukaemia; oncogenes and fragile sites

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Summary

Three hundred and twenty-five aberrant breakpoints in chronic myelogenous leukaemia (CML) with Philadelphia chromosome variant were reviewed. Eight chromosomal bands (3p21, 6p21, 7p22, 11q13, 12p13, 17p13, 17q21, and 17q25) were found to be highly involved. Apart from 17q25, all these bands correspond to oncogenes sites and/or sites involved as primary breakpoints in cancer.

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References

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Authors and Affiliations

  1. Département d'Hématologie et Oncologie Médicale, Hôpital Jean Bernard, F-86021, Poitiers Cedex, France

    J. L. Huret & J. Tanzer

  2. Département de Statistique Médicale, Institut Gustave Roussy, F-94805, Villejuif Cedex, France

    M. Henry-Amar

Authors
  1. J. L. Huret
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  2. J. Tanzer
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  3. M. Henry-Amar
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Huret, J.L., Tanzer, J. & Henry-Amar, M. Aberrant breakpoints in chronic myelogenous leukaemia; oncogenes and fragile sites. Hum Genet 74, 447–448 (1986). https://doi.org/10.1007/BF00280504

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  • DOI: https://doi.org/10.1007/BF00280504

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