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Influence of prolonged neuropsychological testing on immunoregulatory cells and hormonal parameters in patients with systemic lupus erythematosus

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Summary

The influence of a 2-h neuropsychological stress test on plasma catecholamines, cortisol, and on the distribution of lymphocyte subpopulations was studied in 14 patients with systemic lupus erythematosus (SLE), 10 patients on prednisone treatment (without collagenosis), and 14 sex-and-age-matched healthy controls. Psychological stress induced comparably significant increases in plasma adrenaline and noradrenaline levels as compared with baseline values (P<0.05) in all three groups, whereas plasma cortisol remained unchanged. The rise in plasma catecholamines was accompanied by a significant cell mobilization in healthy subjects and prednisone-treated patients, but not in patients with SLE. CD19+ cells increased significantly in number from baseline in healthy subjects and prednisone-treated controls (P<0.05), while remaining unchanged, in SLE patients. In conclusion, SLE patients showed a reduced cell mobilization due to psychological stress despite hormonal alterations paralleling those of healthy subjects or prednisone-treated patients without collagenosis.

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References

  1. Landmann RMA, Müller FB, Perini C, Wesp M, Erne P, Bühler R (1984) Changes of immunoregulatory cells induced by psychological and physical stress: relationship to plasma catecholamines. Clin Exp Immunol 58:127–135

    Google Scholar 

  2. Hutt HJ, Kirch W, Kreuzfelder E, Scheiermann N, Ohnhaus EE (1986) Changes in normal subjects and patients with systemic lupus erythematosus (SLE). Eur J Clin Invest 16:35, 193 (abstr)

    Google Scholar 

  3. Maisel AS, Knowlton KU, Fowler P, Rearden A, Ziegler MG, Motulsky HJ, Insel PA, Michel MC (1990) Adrenergic control of circulating lymphocyte subpopulations. J Clin Invest 85:462–467

    Google Scholar 

  4. Steel CM, French EB, Aitchison WRC (1971) Studies on adrenaline-induced leucocytosis in normal man. I. The role of the spleen and of the thoracic duct. Br J Haematol 21:413–421

    Google Scholar 

  5. Gader AMA, Cash JD (1975) The effect of adrenaline, noradrenaline, isoprenaline and salbutamol on the resting levels of white blood cells in man. Scand J Haematol 14:5–10

    Google Scholar 

  6. Eriksson B, Hedfors E (1977) The effect of adrenaline, insulin and hydrocortisone on human peripheral blood lymphocytes studied by cell surface markers. Scand J Haematol 18:121–128

    Google Scholar 

  7. Hedfors E, Holm G, Öhnell B (1976) Variations of blood lymphocytes during work studied by cell surface markers, DNA synthesis and cytotoxicity. Clin Exp Immunol 24:328–335

    Google Scholar 

  8. Hedfors E, Holm G, Ivansen M, Wahren J (1983) Physiological variation of blood lymphocyte reactivity: T-cell subsets, immunglobulin production, and mixed-lymphocyte reactivity. Clin Immunol Immunopathol 27:9–14

    Google Scholar 

  9. Landmann RMA, Bürgisser E, Wesp M, Bühler FR (1984) Beta-adrenergic receptors are different in subpopulations of human circulating lymphocytes. J Recept Res 4:37–50

    Google Scholar 

  10. Hinrichsen H, Barth J, Ferstl R, Kirch W (1989) Changes of immunregulatory cells induced by acoustic stress in patients with systemic lupus erythematosus, sarcoidosis, and in healthy controls. Eur J Clin Invest 19:372–377

    Google Scholar 

  11. Tönnesen E, Christensen NJ, Brinklö MM (1987) Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers. Eur J Clin Invest 17:497–503

    Google Scholar 

  12. Hedfors E (1976) Lymphocyte mobilization in response to physical work in sarcoidosis. Influence on lymphocyte subpopulations, DNA synthesis and cytotoxicity. Scand J Resp Dis 57:151–159

    Google Scholar 

  13. Slade JD, Hepburn B (1983) Prednisone-induced alterations of circulating human lymphocyte subsets. J Lab Clin Med 101:479–487

    Google Scholar 

  14. Hoffman T (1980) Natural killer function in SLE. Arthritis Rheum 23:30

    Google Scholar 

  15. Karsh J, Porval G, Osterland CK (1981) Natural cytotoxicity in rheumatoid arthritis and SLE. Clin Immunol Immunopathol 19:437–446

    Google Scholar 

  16. Tsokos GC, Kook AH, D'Jeu JY, Balow JE (1982) Natural killer cells and interferon responses in patients with SLE. Clin Exp Immunol 50:239–245

    Google Scholar 

  17. Sibbit WL, Froelich CJ, Bankhurst AD (1983) Natural cytotoxicity in SLE: mechanisms of suppression by inhibitory serum factors. Clin Exp Immunol 50:246–252

    Google Scholar 

  18. Blaszyk M, Majewski S, Wasik M, Chorzeski T, Jablouska S (1987) Natural killer cell activity of peripheral blood mononuclear cells from patients with various forms of lupus erythematosus. Br J Dermatol 117:709–714

    Google Scholar 

  19. Gaspar ML, Kvarez-Mon M, Gutierrez C (1988) Role of Interleukin 2 in inducing normalization of natural killer activity in SLE. Clin Immunol Immunopathol 49:204–214

    Google Scholar 

  20. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Green Schaller J, TaLal N, Winchester RJ (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277

    Google Scholar 

  21. Glinski W, Gershwin ME, Budman DR, Steinberg AD (1976) Study of lymphocyte subpopulations in normal humans and patients with systemic lupus erythematosus by fractionation of peripheral blood lymphocytes on a discontinuous Ficoll gradient. Clin Exp Immunol 26:228–238

    Google Scholar 

  22. Sakane T, Steinberg AD, Green I (1978) Studies of immune fractions of patients with systemic lupus erythematosus. I. Dysfunction of suppressor T-cell activity related to impaired generation of, rather than response to, suppressor cells. Arthritis Rheum 21:657–664

    Google Scholar 

  23. Smolen JS, Chused TM, Leiserson WM, Reeves JP, Alling D, Steinberg AD (1982) Heterogeneity of immunoregulatory T-cell subsets in systemic lupus erythematosus. Am J Med 72:783–790

    Google Scholar 

  24. Brickenkamp R (1972) Handanweisung zum Test d2 Aufmerksamkeits- und Belastungstest. Hogrefe, Göttingen

    Google Scholar 

  25. Lehrl S (1976) Manual zum Mehrfachwahl-Wortschatz-Test (MWT-B). Straube, Erlangen

    Google Scholar 

  26. Erzigkeit H (1986) Manual zum Syndrom-Kurzzeit-Test (SKT) Form A-E Vless, München

  27. Cohen R, Rist F. Sequential effects in the reaction times of schizophrenics: crossover and modality shift effects. In: Nafrallah HA (ed) Handbook of schizophrenia. Elsevier, Amsterdam (in press)

  28. Benton AL (1972) Handanweisung zum Bentontest. Huber, Bern

    Google Scholar 

  29. Wechsler D (1964) Testband zum Hamburg-Wechsler-Intelligenztest für Erwachsene (HAWIE). Huber, Bern

    Google Scholar 

  30. Böyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. J Clin Lab Invest 21 [Suppl 97]:77–89

    Google Scholar 

  31. Bourne JR (1983) Handbook of immunoperoxidase staining methods. Dako, Santa Barbara, Calif

    Google Scholar 

  32. Gregory CD, Shah LP, Lee H, Golding PR (1986) Analysis of lymphocyte subpopulations in cytocentrifuge preparations. Med Lab Sci 43:59–63

    Google Scholar 

  33. Kan EAR, Wang CY, Wang LC, Evans RL (1983) Noncovalently bonded subunits of 22 and 28 kd are rapidly internalized by T cells reacted with anti-Leu 4 antibody. J Immunol 131:536–539

    Google Scholar 

  34. Kaneoka H, Perez-Rojas G, Sasasaki T, Benike CJ, Engleman EG (1983) Human T lymphocyte proliferation induced by a Pan-T monoclonal antibody (Anti-Leu 4): heterogeneity of response is a function of monocytes. J Immunol 131:158

    Google Scholar 

  35. Nadler LM, Anderson KL, Marti G, Bates M, Park E, Dahy JF, Schlossman SF (1983) B4, a human B lymphocyte-associated-antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol 131:244–250

    Google Scholar 

  36. Ledbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Goal RA, Herzenberg LA (1981) Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J Exp Med 153:310–323

    Google Scholar 

  37. Engleman EG, Benike CJ, Glickman E, Evans RL (1981) Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. J Exp Med 153:193–198

    Google Scholar 

  38. Abo T, Balch CM (1981) A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 127:1025–1029

    Google Scholar 

  39. Laurier LL, Le AM, Phillips JH, Werner NL, Babcock GF (1983) Subpopulations of human natural killer cells defined by expression of the Leu-7 (HNK 1) and Leu-11 (NK-15) Antigens. J Immunol 131:1789–1796

    Google Scholar 

  40. Sachs L (1984) Applied statistics, 2nd edn. Springer, New York

    Google Scholar 

  41. Landmann RMA, Portenier M, Staehelin M, Wesp M, Box R (1988) Changes in β-adrenoreceptors and leucocyte subpopulations after physical exercise in normal subjects. Naunyn Schmiedebergs Arch Pharmacol 337:261–266

    Google Scholar 

  42. Yu DTY, Clements PJ, Paulus HE, Peter JB, Levy J, Barnett EV (1974) Human lymphocyte subpopulations. Effect of corticosteroids. J Clin Invest 53:565–571

    Google Scholar 

  43. Fauci AS, Dale DC (1974) The effect of in vivo hydrocortisone on subpopulations of human lymphocytes. J Clin Invest 53:240–246

    Google Scholar 

  44. Fauci AS, Dale DC (1975a) Alternate-day prednisone therapy and human lymphocyte subpopulations. J Clin Invest 55:22–32

    Google Scholar 

  45. Fauci AS, Dale DC (1975b) The effect of hydro-cortisone on the kinetics of normal human lymphocytes. Blood 46:235–243

    Google Scholar 

  46. Haynes BF, Fauci AS (1978) The differential effect of in vivo hydrocortisone on the kinetics of subpopulations of human peripheral blood thymus-derived lymphocytes. J Clin Invest 61:703–707

    Google Scholar 

  47. Ten Berge RJM, Sauerwein HP, Yong SL, Schellekens PTA (1984) Administration of prednisolone in vivo effects the ratio of OKT4/OKT8 and the LDH-isoenzyme pattern of human T-lymphocytes. Clin Immunol Immunopathol 30:91–103

    Google Scholar 

  48. Halberg F, Frank G, Harner R, Mathews J, Aaker H, Gravem H, Melby J (1961) The cortical adrenal cycle in man on different schedules of motor and mental activity. Experientia 17:282

    Google Scholar 

  49. Miyawaki T, Taga K, Nagaoki T, Seki H, Suzuki Y, Taniguchi N (1984) Circadian changes of T lymphocyte subsets in human peripheral blood. Clin Exp Immunol 55:618–622

    Google Scholar 

  50. Krawitz W, Werdan K, Schober M, Erdmann E, Rindfleisch G, Hannig K (1982) Different numbers of β-receptors in human lymphocyte subpopulations. Biochem Pharmacol 31:133–136

    Google Scholar 

  51. Khan R (1986) Beta-adrenergic receptors on human suppressor, helper and cytolytic lymphocytes. Biochem Pharmacol 35:1137–1142

    Google Scholar 

  52. Ferrell PB, Tan EM (1985) Systemic lupus erythematosus. In: Rose R, Mackay J (eds) The autoimmune diseases. Academic Press, Orlando, Fla., pp 29–57

    Google Scholar 

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Authors and Affiliations

  1. Medical Division I, Christian Albrechts University, Schittenhelmstraße 12, D-2300, Kiel, Federal Republic of Germany

    H. Hinrichsen, J. Barth, M. Rückemann & W. Kirch

  2. Institute of Psychology, Christian Albrechts University, Schittenhelmstraße 12, D-2300, Kiel, Federal Republic of Germany

    R. Ferstl

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  1. H. Hinrichsen
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  2. J. Barth
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  3. M. Rückemann
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  4. R. Ferstl
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  5. W. Kirch
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Hinrichsen, H., Barth, J., Rückemann, M. et al. Influence of prolonged neuropsychological testing on immunoregulatory cells and hormonal parameters in patients with systemic lupus erythematosus. Rheumatol Int 12, 47–51 (1992). https://doi.org/10.1007/BF00300976

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  • DOI: https://doi.org/10.1007/BF00300976

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