Abstract
A preliminary double-blind controlled study on the prophylactic effect of carbamazepine on recurrent manic-depressive psychotics was conducted with 22 patients using an inert placebo in ten subjects as a control drug. Carbamazepine in the dosage of 200–600 mg was administered for 1 year. Among the 22 carbamazepine subjects, carbamazepine was found to be effective in 60% of the cases and inert placebo in 22.2% (U-test, P<0.10). It is suggested that carbamazepine is a useful drug for the prophylaxis of manic-depressive illness.
References
International Classification of Diseases (1977) 1925 Revision, vol 1. World Health Organization. Geneva, pp 185–189
Okuma T, Kishimoto A, Inoue K, Matsumoto H, Ogura A, Matsushita T, Nakao T, Ogura C (1973) Anti-manic and prophylactic effects of carbamazepine (Tegretol) on manic-depressive psychosis. A preliminary report. Folia Psychiatr Neurol Jpn 27:283–297
Okuma T, Kishimoto A, Inoue K, Ogura C, Motoike M, Matsushima Y, Nakamura K, Tanaka K, Majima K, Matsushita T, Matsumoto H, Ogura A (1975) Anti-manic and prophylactic effects of carbamazepine (Tegretol) on manic-depressive psychosis. Seishin-igaku 17:617–630 (in Japanese)
Okuma T, Inanaga K, Osuki S, Sarai K, Takahshi R, Hazama H, Mori A, Watanabe S (1979) Comparison of the anti-manic efficacy of carbamazepine and chlorpromazine: double-blind controlled study. Psychopharmacology 56:211–217
Takahashi R, Itoh K, Itoh H, Kurihara M, Saitoh M, Sakuma A, Watanabe S (1974) Comparison of anti-manic efficacies of lithium carbonate and chlorpromazine by a double-blind test. Clin Eval 2:23–45
Takezaki H, Hanaoka M (1971) The use of carbamazepine (Tegretol) in the control of manic-depressive psychosis and other manic-depressive states. Seishin-igaku 13:173–183 (in Japanese)
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Okuma, T., Inanaga, K., Otsuki, S. et al. A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness. Psychopharmacology 73, 95–96 (1981). https://doi.org/10.1007/BF00431111
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DOI: https://doi.org/10.1007/BF00431111