Summary
The X-linked geneLSPI-α ofDrosophila melanogaster, expressed in the third larval instar, does not exhibit dosage compensation at its normal locus but does compensate when it is relocated to ectopic sites on the X chromosome. A transcription unit designatedL12, which is active in the second larval instar and capable of encoding a putative protein of 28.5 kDa, lies immediately downstream fromLSPI-α. We have determined thatL12 is dosage compensated by measuring the steady-state level of its transcript in male and female larvae. The difference in response of these two adjacent genes should be taken into consideration when models of the mechanism of dosage compensation are formulated.
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Communicated by B.H. Judd
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Ghosh, S., Lucchesi, J.C. & Manning, J.E. The non-dosage compensatedLSPI -α gene ofDrosophila melanogaster lies immediately downstream of the dosage compensatedL12 gene. Molec. Gen. Genet. 233, 49–52 (1992). https://doi.org/10.1007/BF00587560
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DOI: https://doi.org/10.1007/BF00587560