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Trials and tribulations of multicenter studies

Lessons learned from the experiences of the Southwest Pediatric Nephrology Study Group (SPNSG)

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Abstract

Multicenter studies in Pediatric Nephrology have been acknowledged in recent years as an important mechanism for studying renal disease in children. The purpose of this review is to describe some of the experiences of the Southwest Pediatric Nephrology Study Group (SPNSG) in order to assist others in developing their own multicenter studies. The importance of protocol development, including adequate attention to study design, data management, and data analysis, is emphasized. Mechanisms for facilitating the frequency and productivity of study group meetings that are so essential for the success of multicenter studies, are described in some detail. The need and some of the methods for achieving ongoing collaboration within a climate of critical peer review are also discussed. Controversial issues such as authorship and the question of institutional credit for involvement in multicenter studies are discussed in brief. Finally, some of the features of the SPNSG that have permitted us to meintain a relatively high rate of productivity are described. The two most important of these, ongoing commitment to the group and willingness to collaborate across differences of opinion, are stressed throughout the review.

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References

  1. Hokken A, Wolff E, Jong M de, Donckerwolcke R, Abbad N, Drop S, Keizer S de Muinck, Wit J, Gons M, Otten B (1990) A placebo controlled double-blind trial of growth hormone treatment in children with chronic renal insufficiency (abstract). Paediatric Nephrology, 4:C41

    Google Scholar 

  2. Verrina E, Zaccheolo G, Perfumo F, Edefonti A, Bassi S, Picca M, Castellani A, Piaggio G, Andreetta B, Longo L, Rinaldi S, Pela I, Cavilli PL, Ragaiolo G, Caringella A, Penza R, Penza R, Gusmano R (Italian Pediatric CPD Registry) (1990) Chronic peritoneal dialysis (CPD) in children: a multicenter clinical study (abstract). Paediatric Nephrology 4:C45

    Google Scholar 

  3. Gianviti A (The Italian HUS Collaborating Group and International Registry) (1990) Plasmapheresis in children with haemolytic uraemic syndrome (HUS) older than five (abstract). Paediatric Nephrology, 4:C48

    Google Scholar 

  4. Wingen A-M, Fabian C for the European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood (1990) Multicenter randomized study on the effect of a low protein diet on the progression of CRF in children — one year results (abstract). Paediatric Nephrology, 4:C50

    Google Scholar 

  5. Kist-van Holthe tot Echten Echten JE, Nauta J, Hop WCJ, Jong MCJW de, Luijk WHJ van, Ploos van Amstel SLB, Roodhooft AM, Noordzij CM, Wolff ED (1990) Multicenter prospective randomized study on the effect of protein restriction on renal function and growth of children with chronic renal failure (abstract). Paediatic Neuphrology, 4:C50

    Google Scholar 

  6. Beattie TJ (on behalf of the British Association for Paediatric Nephrology Research Group) (1990) Levamisole in corticosteroid dependent nephrotic syndrome: a double blind, placebo controlled trial (abstract). Paediatric Nephrology, 4:C52

    Google Scholar 

  7. Niaudet P,and the French Club of Pediatric Nephrology (1990) Steroid resistant idiopathic nephrotic syndrome and ciclosporine (abstract). Paediatric Nephrology, 4:C52

    Google Scholar 

  8. Edefonti A, Ghio L, Rizzoni G, Gusmano R, Lama G, Zacchello G, Andreucci A, Castellani A, Cinotti G, Confalonieri R, Bettinelli A, Perini A, Rinaldi S, Della Casa O, Ponticelli C (1990) A multicenter randomized study of cyclosporin A compared with cyclophosphamide in steroid-dependent/frequently relapsing nephrotic syndrome (abstract). Paediatric Nephrology, 4:C52

    Google Scholar 

  9. Olbing H on behalf of the International Reflux Study in Children (1990) Contralateral renal hypertrophy in children with unilateral segmental renal scars (abstract). Paediatric Nephrology, 4:C54

    Google Scholar 

  10. Hoyer PF for the APN (1990) Cyclosporin A in MCNS: CsA study II of the Arbeitsgemeinschaft für Pädiatrische Nephrologie (abstract). Paediatric Nephrology, 4:C60

    Google Scholar 

  11. Ehrich JHH for Arbeitsgemeinschaft für Pädiatrische Nephrologie (APN) (1990) Minimal change nephrotic syndrome (MCNS):long prednisone therapy versusstandard prednisone therapy (abstract). Paediatric Nephrology, 4:C60

    Google Scholar 

  12. A multicenter study of IgA nephropathy in children-report of the Southwest Pediatric Nephrology Study Group. Kidney Int 22:643–652, 1982

    Google Scholar 

  13. Childhood nephrotic syndrome associated with diffuse mesangial hypercellularity. Report of the Southwest Pediatric Nephrology Study Group. Kidney Int 24:86–94, 1983

    Google Scholar 

  14. Focal segmental glomerulosclerosis in children with idiopathic nephrotic syndrome. A report of the Southwest Pediatric Nephrology Study Group. Kidney Int 27:442–449, 1985

  15. A clinico-pathologic study of crescentic glomerulonephritis in 50 children. A report of the Southwest Pediatric Nephrology Study Group. Kidney Int 27:450–458, 1985

    Google Scholar 

  16. Hepatitis B surface antigenemia in North American children with membranous glomerulonephropathy. A report of the Southwest Pediatric Nephrology Study Group. J Pediatr 106:571–578, 1985

  17. Association of IgA nephropathy with steroid-responsive nephrotic syndrome. A report of the Southwest Pediatric Nephrology Study Group. Am J Kidney Dis 3:157–164, 1985

    Google Scholar 

  18. Continuous ambulatory and continuous cycling peritoneal dialysis in children. A report of the Southwest Pediatric Nephrology Study Group. Kidney Int 27:558–564, 1985

    Google Scholar 

  19. Dense deposit disease in children: prognostic value of clinical and pathologic indicators. A report of the Southwest Pediatric Nephrology Study Group. Am J Kidney Dis 6:161–169, 1985

  20. Comparison of idiopathic and systemic lupus erythematosus associated membranous glomerulonephropathy in children. A report of the Southwest Pediatric Nephrology Study Group. Am J of Kidney Dis 7:115–124, 1986

  21. Cole BR, Conley SB, Stapleton FB for the Southwest Pediatric Nephrology Study Group: Polycystic kidney disease presenting in the first year of life. J Pediatr 111:693–699 1987

    PubMed  Google Scholar 

  22. Beckman BS, Brookins JW, Shadduck RK, Mangan KF, Deftos LJ, Fisher JW: Effect off different modes of dialysis on serum erythropoietin levels in pediatric patients. A report of the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol. 2:436–441, 1988

    PubMed  Google Scholar 

  23. Verani R, Walker P, Silva FG for the Southwest Pediatric Nephrology Study Group: Renal cystic disease of infancy. Results of histochemical studies. Pediatr Nephrol 3:37–42, 1989

    PubMed  Google Scholar 

  24. Beckman BS, Brookins J, Fisher JW: Measurement of erythropoietin in anephric children. A report of the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol 3:75–79, 1989

    PubMed  Google Scholar 

  25. Hawkins EP, Berry PL, Silva FG for the Southwest Pediatric Nephrology Study Group: Acute tubulointerstitial nephritis in children: clinical, morphologic, and lectin studies. Am J Kidney Dis 14:466–471, 1989

    PubMed  Google Scholar 

  26. Argyle JC, Hogg RJ, Pysher TJ, Silva FG, Siegler RL: A clinicopathologic study of 24 children with hemolytic uremic syndrome: a report of the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol 4:52–58 1990

    PubMed  Google Scholar 

  27. Stapleton FB: Idiopathic hypercalciuria: association with isolated hematuria and subsequent risk for urolithiasis in children. A report of the Southwest Pediatric Nephrology Study Group. Kidney Int 37: 807–811, 1990

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Southwest Pediatric Nephrology Study Group, Baylor University Medical Center, Dallas, Texas, USA

    Ronald J. Hogg

  2. Department of Pediatrics, Baylor University Medical Center, Dallas, Texas, USA

    Ronald J. Hogg

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  1. Ronald J. Hogg
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Additional information

SPNSG centers Baylor College of Medicine, Houston, Tex.; Baylor University Medical Center, Dallas, Tex.; Cook-Fort Worth Children's Medical Center, Fort Worth, Tex., Louisiana State University, New Orleans, La.; Texas A and M University, Temple, Tex.; Tulane University Medical Center, New Orleans, La.; University of Alabama at Birmingham, Birmingham, Ala.; University of Arkansas, Little Rock, Ark.; University of Colorado, Denver, Colo.; Oklahoma University Health Science Center, Oklahoma City, Okla.; University of Tennessee, Memphis, Tenn.; University of Texas Health Science Center, San Antonio, Tex.; University of Texas Medical Branch, Galveston, Tex.; University of Texas Medical School, Houston, Tex.; University of Texas Southwestern Medical Center, Dallas, Tex.; University of Utah, Salt$Lake City, Utah

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Hogg, R.J. Trials and tribulations of multicenter studies. Pediatr Nephrol 5, 348–351 (1991). https://doi.org/10.1007/BF00867501

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  • DOI: https://doi.org/10.1007/BF00867501

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