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Acute induction of joint inflammation in the rat by Poly I · Poly C

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Abstract

Intraarticular injection of interferon inducer, double-stranded polyinosinate-polycytidylate (Poly I · C) caused acute synovitis in rats. This acute inflammatory response was accompanied by an increased concentration of prostaglandin E (PGE) in the synovial tissue. Double-stranded polyadenylate-polyuridylate (Poly A · Poly U) was less potent than Poly I · Poly C in inducing synovitis and increasing PGE concentration, while single-stranded polyinosinate (Poly I) or polycytidylate (Poly C) were inactive in these respects. Intraarticular injection of partially purified mouse fibroblast interferon also induced synovial inflammation. The present results suggest that interferon may be a mediator of viral inflammatory responses.

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Authors and Affiliations

  1. Arthur and Nela Rubinstein Arthritis Research Unit, Departments of Physical Medicine and Rheumatology and Pathology, Rokach and Ichilov Medical Center, Tel-Aviv University, Israel

    Michael Yaron, Mimi Baratz, Ilana Yaron & Uriel Zor

  2. Sackler Medical School, and Department of Hormone Research, The Weizmann Institute of Science, Rehovot, Israel

    Michael Yaron, Mimi Baratz, Ilana Yaron & Uriel Zor

Authors
  1. Michael Yaron
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  2. Mimi Baratz
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  3. Ilana Yaron
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  4. Uriel Zor
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Investigation supported in part by a grant from the Chief Scientist's Office, Ministry of Health, Israel.

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Yaron, M., Baratz, M., Yaron, I. et al. Acute induction of joint inflammation in the rat by Poly I · Poly C. Inflammation 3, 243–251 (1979). https://doi.org/10.1007/BF00914181

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