Skip to main content
SpringerLink
Log in

Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract

  • Clinical Investigation
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

• Background: Experimental evidence suggests a role of endothelin-1 (ET) in the regulation of intraocular pressure (IOP). • Method: Therefore, inpatients undergoing cataract surgery, ET-like immunoreactivity (STIR) was measured by radioimmunoassay in pooled samples of aqueous humor of eyes with primary open-angle glaucoma (POAG) and normotensive eyes with cataract only. • Results: ETIR was significantly (P < 0.05) higher in patients with cataract and POAG (20.5 ± 1.8 pg/ml,n = 12; preoperative IOP 21.4 ± I.1 mmHg,n = 33) than in patients with cataract only (15.8 ± 1.6 pg/m1,n = 15; preoperative IOP 16.0 ± 0.6 mmHg,n = 77). • Conclusion: This finding may indicate a role of ET in POAG or ocular antihypertensive treatment, and its relevance should be further investigated.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Erickson-Lamy K, Korbmacher C, Schuman JS, Nathanson JA (1991) Effect of endothelin on outflow facility and accommodation in the monkey eye in vivo. Invest Ophthalmol Vis Sci 32:492–495

    PubMed  Google Scholar 

  2. Kaiser HJ, Hammer J, Wenk M, Lüscher T (1995) Endothelin-1 plasma levels in normal-tension glaucoma: abnormal response to postural changes. Graefe's Arch Clin Exp Ophthalmol 233:484–488

    Google Scholar 

  3. Lepple-Wienhues A, Stahl F, Willner U, Schäfer R, Wiederholt M (1991) Endothelin-evoked contractions in bovine ciliary muscle and trabecular meshwork: interaction with calcium, nifedipine and nickel. Curr Eye Res 10:983–989

    PubMed  Google Scholar 

  4. Lepple-Wienhues A, Becker M, Stahl F, Berweck S, Hensen J, Noske W, et al (1992) Endothelin-like immunoreactivity in the aqueous humor and in conditioned medium from cultured ciliary epithelial cells. Curr Eye Res 11:1041–1046

    PubMed  Google Scholar 

  5. MacCumber MW, Jampel HD, Snyder SH (1991) Ocular effects of the endothelins. Abundant peptides in the eye. Arch Ophthalmol 109:705–709

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Benjamin Franklin University Hospital, Free University of Berlin, Berlin, Germany

    Walter Noske

  2. Department of Internal Medicine, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany

    Johannes Hensen

  3. Department of Clinical Physiology, Benjamin Franklin University Hospital, Free University of Berlin, D-12200, Berlin, Germany

    Michael Wiederholt

Authors
  1. Walter Noske
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Johannes Hensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael Wiederholt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Noske, W., Hensen, J. & Wiederholt, M. Endothelin-like immunoreactivity in aqueous humor of patients with primary open-angle glaucoma and cataract. Graefe's Arch Clin Exp Ophthalmol 235, 551–552 (1997). https://doi.org/10.1007/BF00947082

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00947082

Keywords

Search

Navigation