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Immunological responses of breast cancer patients to behavioral interventions

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Abstract

This article reports the results of an 18-month study of immune system and psychological changes in stage 1 breast cancer patients provided with relaxation, guided imagery, and biofeedback training. Thirteen lymph node negative patients who had recovered from a modified radical mastectomy were randomly assigned to either an immediate treatment or a delayed treatment control group. Multiple pre-post psychological measures were performed. Significant effects were found in natural killer cell (NK) activity (p<.017), mixed lymphocyte responsiveness (MLR) (p<.001), concanavalin A (Con-A) responsiveness (p<.001), and the number of peripheral blood lymphocytes (PBL) (p<.01). No significant psychological changes were detected; however, reductions were seen in psychological inventory scales measuring anxiety. The results show that behavioral interventions can be correlated with immune system measures, thereby replicating the results of an earlier pilot study from our Center. Discussion is provided on differential T-cell and B-cell responsiveness to behavioral interventions.

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Authors and Affiliations

  1. Medical Illness Counseling Center, Two Wisconsin Circle, Suite 530, 20815, Chevy Chase, Maryland

    Barry L. Gruber Ph.D. (Director of Clinical Research), Stephen P. Hersh (Clinical Professor), Lucy R. Waletzky (Assistant Clinical Professor), John F. Kunz, Joann K. Carpenter, Karan S. Kverno & Sharlene M. Weiss

  2. Department of Psychiatry and Pediatrics, George Washington University School of Medicine, Washington, D.C.

    Stephen P. Hersh (Clinical Professor)

  3. Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland

    Stephen P. Hersh (Clinical Professor)

  4. Department of Psychiatry, University of South Florida School of Medicine, Tampa, Florida

    Nicholas R. S. Hall

  5. Department of Psychiatry and Obstetrics and Gynecology, Georgetown University Medical Center, Washington, D.C.

    Lucy R. Waletzky (Assistant Clinical Professor)

Authors
  1. Barry L. Gruber Ph.D.
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  2. Stephen P. Hersh
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  3. Nicholas R. S. Hall
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  4. Lucy R. Waletzky
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  5. John F. Kunz
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  6. Joann K. Carpenter
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  7. Karan S. Kverno
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  8. Sharlene M. Weiss
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Additional information

We wish to thank Douglas B. Coulson, Ph.D. for his expertise on the statistical analysis of the data. We would also like to thank Clay Steiner, M.D.; Janelle Oliver, M.S.; Maureen O'Grady, Ph.D.; and Rena Goetz, Ph.D., for their contribution to the performance of the assays. Finally, we thank both Sandy Bangham, R. N., and the medical laboratory staff at The Washington Clinic, Washington, D.C. for their services in performing phlebotomy.

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Gruber, B.L., Hersh, S.P., Hall, N.R.S. et al. Immunological responses of breast cancer patients to behavioral interventions. Biofeedback and Self-Regulation 18, 1–22 (1993). https://doi.org/10.1007/BF00999510

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