Skip to main content
SpringerLink
Log in

Inflammatory pseudotumors (inflammatory fibrous polyps) of the esophagus

A clinicopathologic study

  • Original Articles
  • Published:
The American Journal of Digestive Diseases Aims and scope Submit manuscript

Abstract

When they involve the gastrointestinal tract, inflammatory pseudotumors, composed of inflamed fibrous and granulation tissue, produce localized, frequently polypoid, masses. These rare lesions have been described in the stomach, small intestine, and colon. Only two have been previously reported in the esophagus. In this paper, 4 cases of inflammatory pseudotumor involving the esophagus are presented. These lesions usually occur in the esophagus as raised, occasionally pedunculated, masses and may be mistaken on radiologic examination and in the operating room for a neoplasm, usually a leiomyoma. Theories concerning pathogenesis of these lesions are considered and the differential diagnostic criteria are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Vanek J: Gastric submucosal granuloma with eosinophilic infiltration. Am J Pathol 25:397–411, 1949

    Google Scholar 

  2. Ureles AL, Alschibaja T, Lodico D, et al: Idiopathic eosinophilic infiltration of the gastrointestinal tract, diffuse and circumscribed. Am J Med 30:899–909, 1961

    Google Scholar 

  3. Goldman RL, Friedman NB: Neurogenic nature of so-called inflammatory fibroid polyps of the stomach. Cancer 20:134–143, 1967

    Google Scholar 

  4. Helwig EB, Ranier A: Inflammatory fibroid polyps of the stomach. Surg Gynecol Obstet 96:355–367, 1953

    Google Scholar 

  5. Ming SC: Tumors of the esophagus and stomach. AFIP fascicle Number 7, Second series. Washington DC, 1973

  6. Samter TG, Alstott DF, Kurlander GJ: Inflammatory fibroid polyps of the gastrointestinal tract. Am J Clin Pathol 45:420–436, 1966

    Google Scholar 

  7. Salm R: Gastric fibroma with eosinophilic infiltration. Gut 6:85–91, 1965

    Google Scholar 

  8. Booher RJ, Grant RN: Eosinophilic granuloma of the stomach and small intestine. Surgery 30:388–397, 1951

    Google Scholar 

  9. Cox JST: Submucosal ileal granuloma with eosinophilic infiltration and intussusception. Br J Surg 48:149–150, 1960

    Google Scholar 

  10. Koneman EW, Sawyer KC, Lubchenco AE: Eosinophilic granuloma of the ileum. Arch Surg 78:923–927, 1959

    Google Scholar 

  11. Persoff MM, Arterburn JG: Eosinophilic granuloma causing intussusception in a three year old child. Am J Surg 124:676–678, 1972

    Google Scholar 

  12. Polayes SH, Krieger JL: Eosinophilic granuloma of the jejunum: A hitherto undescribed lesion of the intestines. JAMA 143: 549–551, 1950

    Google Scholar 

  13. Ramirez AB, ReMine WH, Harrison EG: Inflammatory fibrous polyp (pseudotumor) or ileum. Postgrad Med 54:107–113, 1973

    Google Scholar 

  14. McGee HJ: Inflammatory fibroid polyps of the ileum and cecum. Arch Pathol 70:203–207, 1960

    Google Scholar 

  15. Pardo MV, Rodriquez TI: Eosinophilic granuloma of the colon. Arch Hosp Univ Habana 4:248, 1952

    Google Scholar 

  16. Leand PM, Murray GF, Zuidema GD, et al: Obstructing esophageal polyp with eosinophilic infiltration. Am J Surg 116:93–96, 1968

    Google Scholar 

  17. Schreiber MH: Granuloma of the esophagogastric junction with eosinophilic infiltration. Gastroenterology 43:206–211, 1962

    Google Scholar 

  18. Pearce AE, Ivker M, Oller S: Fibroma of ileum (diagnosed preoperatively by barium enema as benign polypoid tumor) and a review of benign small intestinal tumors. Surgery 36:299–305, 1954

    Google Scholar 

  19. Pheils MT: A submucous fibroma of the ileum causing intussusception. Br J Surg 40:135–137, 1952

    Google Scholar 

  20. Paulian D, Badea A, Garess H, et al: A case of neurinoma of the small intestine. Lyon Chir 67:307–308, 1971

    Google Scholar 

  21. Olsen EGJ, Wellwood JM: Hemangiopericytoma of the small intestine. A report of three cases. Br J Surg 57:66–69, 1970

    Google Scholar 

  22. Harkin JC, Reed RJ: Tumors of the peripheral nervous system. AFIP fascicle number 3, Second series. Washington DC, 1969

  23. Fenton F, Matz LR, Golinger D: Inflammatory fibroid polyp of the ileum: A case report. Pathology 3:257–262, 1971

    Google Scholar 

  24. O'Neill T: Eosinophilic granuloma of the gastrointestinal tract. Br J Surg 57:704–708, 1970

    Google Scholar 

  25. Pitchumoni CS, Dearani AC, Burke AV, et al: Eosinophilic granuloma of the gastrointestinal tract. JAMA 211:1180–1182, 1970

    Google Scholar 

  26. Salmon PR, Paulley JW: Eosinophilic granuloma of the gastrointestinal tract. Gut 8:8–14 1967

    Google Scholar 

  27. Virshup M, Mandelberg A: Eosinophilic granuloma of the gastrointestinal tract. Ann Surg 139:236–240, 1954

    Google Scholar 

  28. Greenberger NJ, Tennenbaum JI, Ruppert RD: Protein-losing enteropathy associated with gastrointestinal allergy. Am J Med 43:777–784, 1967

    Google Scholar 

  29. Kaplan SM, Goldstein F, Kowlessar OD: Eosinophilic gastroenteritis. Gastroenterology 58:540–545, 1970

    Google Scholar 

  30. Klein NC, Hargrove RL, Sleisinger MH, et al: Eosinophilic gastroenteritis. Medicine 49:299–319, 1970

    Google Scholar 

  31. Waldmann TA, Wochner RD, Laster L, et al: Allergic gastroenteropathy. N Engl J Med 276:761–769, 1967

    Google Scholar 

  32. Mori K, Shinya H, Wolff WI: Polypoid reparative mucosal proliferation at the site of a healed gastric ulcer: Sequential gastroscopic, radiological, and histological observations. Gastroenterology 61:523–529, 1971

    Google Scholar 

  33. Totten RS, Stout AP, Humphreys GH, et al: Benign tumors and cysts of the esophagus. J Thorac Surg 25:606–622, 1953

    Google Scholar 

  34. Jang GC, Clouse ME, Fleischner FG: Fibrovascular polyp—a benign intraluminal tumor of the esophagus. Radiology 92:1196–1200, 1969

    Google Scholar 

  35. Schmidt A, Lockwood K: Benign neoplasms of the esophagus. Acta Chir Scand 133:640–644, 1967

    Google Scholar 

  36. Bernatz PE, Smith JL, Ellis FH, et al: Benign pedunculated intraluminal tumors of the esophagus. J Thorac Surg 35:503–512, 1958

    Google Scholar 

  37. McBride AF: Benign polypoid tumor of the esophagus. Cancer 3:708–716, 1951

    Google Scholar 

  38. Samson PC, Zelman J: Pedunculated tumors of the esophagus. Arch Otolaryngol 36:203–211, 1942

    Google Scholar 

  39. Lane N: Pseudosarcoma (polypoid sarcoma-like masses) associated with squamous cell carcinoma of the mouth, fauces, and larynx: Report of ten cases. Cancer 10:19–41, 1957

    Google Scholar 

  40. Lichtiger B, Mackay B, Tessmar CF: Spindle cell variant of squamous carcinoma: A light and electron microscope study of 13 cases. Cancer 26:1311–1320, 1970

    Google Scholar 

  41. Appelman HD, Oberman HA: Squamous cell carcinoma of the larynx with sarcoma-like stroma. Am J Clin Pathol 44:135–145, 1965

    Google Scholar 

  42. Goellner JR, Devine KD, Weiland LH: Pseudosarcoma of the larynx. Am J Clin Pathol 59:312–326, 1973

    Google Scholar 

  43. Stout AP, Humphreys GH, Rottenberg LA: A case of carcinosarcoma of the esophagus. Am J Roentgenol Radium Ther 61:461–469, 1949

    Google Scholar 

  44. Lin MH, Luna-Munoz MI, Kraft JR, et al: Carcinosarcoma of the esophagus. Am J Gastroenterol 55:249–256, 1971

    Google Scholar 

Download references

Author information

Author notes

  1. Virginia A. LiVolsi MD (Assistant Professor of Pathology)

    Present address: Yale University School of Medicine, New Haven, Connecticut

Authors and Affiliations

  1. Department of Pathology, Division of Surgical Pathology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, 10032, New York, New York

    Virginia A. LiVolsi MD (Assistant Professor of Pathology) &  Karl H. Perzin MD

  2. Laboratory of Surgical Pathology, Presbyterian Hospital, New York

    Virginia A. LiVolsi MD (Assistant Professor of Pathology) &  Karl H. Perzin MD

Authors
  1. Virginia A. LiVolsi MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Karl H. Perzin MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Dr. LiVolsi was formerly a National Cancer Institute Trainee in Surgical Pathology, Columbia University College of Physicians and Surgeons, New York.

Supported in part by National Cancer Institute Traineeship 5 T 1 CA 5107-12 (Dr. LiVolsi).

Rights and permissions

Reprints and permissions

About this article

Cite this article

LiVolsi, V.A., Perzin, K.H. Inflammatory pseudotumors (inflammatory fibrous polyps) of the esophagus. Digest Dis Sci 20, 475–481 (1975). https://doi.org/10.1007/BF01070794

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01070794

Keywords

Search

Navigation