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Interleukin-11 inhibits bone formation in vitro

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Summary

The effects of interleukin-11(IL-11) on the differentiation of osteoblast precursors was tested using a bone nodule forming assay in rat calvaria cell cultures. IL-11 caused a dose dependent inhibition of nodule formation, with 500U/ml IL-11 resulting in complete inhibition of nodule formation. IL-11 also caused a reduction in alkaline phosphatase expression in these cultures. These effects are similar to, but more potent than, the actions of IL-6 on these cells. These results indicate that IL-11 is an osteotropic cytokine and suggest that IL-11 may be an important inhibitor of bone formation in health and disease.

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Authors and Affiliations

  1. Department of Oral Medicine and Periodontology, The London Hospital Medical College, Turner Street, E1 2AD, London, UK

    Francis J. Hughes

  2. Department of Oral Pathology, The London Hospital Medical College, Turner Street, E1 2AD, London, UK

    Gareth L. Howells

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  1. Francis J. Hughes
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  2. Gareth L. Howells
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Hughes, F.J., Howells, G.L. Interleukin-11 inhibits bone formation in vitro. Calcif Tissue Int 53, 362–364 (1993). https://doi.org/10.1007/BF01351844

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  • DOI: https://doi.org/10.1007/BF01351844

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