Summary
Ectopic microscopic thyroid follicles were encountered fortuitously in the submucosa of the duodenum in a 63-year-old man undergoing pancreaticoduodenectomy for pancreatic carcinoma. The follicles, filled with a colloid-like substance, were intermingled with Brunner's glands of the duodenum. There were no signs or symptoms of a thyroid tumour. The epithelial cells and colloid-like substance were both immunoreactive for thyroglobulin but no cells stained for calcitonin. The possibility of a metastatic origin for the follicles from an occult thyroid carcinoma was excluded by the clinical and histopathological findings. These ectopic thyroid follicles cannot be explained by developmental inclusions or metastasis and may be metaplastic in nature.
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References
Allo MD, Christianson W, Koivunen D (1988) Not all occult “papillary carcinomas are minimal”. Surgery 104:971–976
Hashimoto T, Kobo A, Hashimoto S (1988) Twenty cases of ectopic thyroid gland detected by thyroid scintigraphy (in Japanese). Jpn J Clin Radiol 33:357–363
Hoie J, Stenwig AE, Kullmann G, Lindegaard M (1988) Distant metastases in papillary thyroid cancer; a review of 91 patients. Cancer 61:1–6
Kantelip B, Lusson JR, Riberolles CD, Lamaison D, Bailly P (1986) Intracardiac ectopic thyroid. Hum Pathol 17:1293–1296
Lazarus JH, Richards AR, Macpherson JS, Dinnen JS, Williams ED, Owen GM, Wade JSH (1987) Struma ovarii; a case report. Clin Endocrinol 27:715–720
Meyer JS, Steinberg LS (1969) Microscopically benign thyroid follicles in cervical lymph nodes, Serial section study of lymph node inclusions and entire thyroid gland in 5 cases. Cancer 24:302–311
Nicastri AD, Foote FW, Frazell EL (1965) Benign thyroid inclusions in cervical lymph nodes. JAMA 194:113–116
Novak ER, Woodruff JD (1979) Gynecologic and obstetric pathology with clinical and endocrine relations, 8th edn. W.B. Saunders, Philadelphia, pp 490–491
Okamoto N (1983) Clinical human embryology (in Japanese). Nankodo, Tokyo, pp 342–343
Okstad S, Mair IWS, Sundsfjord JA, Eide TJ, Nordrum I (1986) Ectopic thyroid tissue in the head and neck. J Otolaryngol 15:52–55
Rosai J (1981) Ackerman's surgical pathology, 6th edn. C. V. Mosby, St. Louis, pp 1041–1043
Rosai J (1989) Ackerman's surgical pathology, 7th edn. C. V. Mosby. St. Louis, pp 391–394
Sadler TW (1984) Langman's medical embryology, 5th edn. Williams and Wilkins. Baltimore, pp 293–295
Sampson RJ, Oka H, Key CR, Buncher CR, Iijima S (1969) Metastases from occult thyroid carcinoma; an autopsy study from Hiroshima and Nagasaki, Japan. Cancer 25:803–811
Sauk JJ (1970) Ectopic lingual thyroid. J Pathol 102:239–243
Strate SM, Lee EL, Childers JH (1984) Occult papillary carcinoma of the thyroid with distant metastases. Cancer 54:1093–1100
The Japanese Society of Pathology (1987) Annual report of autopsied cases in Japan (in Japanese) vol 30. In: Machinami M, Hosoda Y, Shimosato Y (eds) The Japanese Society of Pathology, Tokyo, pp 1537
The Japanese Society of Pathology (1988) Annual report of autopsied cases in Japan (in Japanese) vol 31. In: Machinami M, Hosoda Y, Shimosato Y (eds) The Japanese Society of Pathology, Tokyo, pp 1529
Walling A (1987) Ectopic thyroid tissue. Am Fam Physician 36:147–150
Yamashita H, Noguchi S, Murakami N, Mochizuki Y, Nakayama I (1986) Prognosis of minute carcinoma of thyroid; follow-up study of 49 patients. Acta Pathol Jpn 36:1469–1475
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Takahashi, T., Ishikura, H., Kato, H. et al. Ectopic thyroid follicles in the submucosa of the duodenum. Vichows Archiv A Pathol Anat 418, 547–550 (1991). https://doi.org/10.1007/BF01606506
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DOI: https://doi.org/10.1007/BF01606506