Summary
The effect of preoperative infusion of Ringer's solution, Ringer's acetate solution, dextran 70, dextran 40, degraded gelatin and hydroxyethyl starch on haemostasis after standardized liver resection was studied in the rat. Ringer's and Ringer's acetate solutions did not affect haemostasis more than expected from haemodilution. Dextrans, degraded gelatin and hydroxyethyl starch caused a significant increase in bleeding time and blood loss. APT time was significantly increased after infusion of hydroxyethyl starch. Dextran and hydroxyethyl starch impaired ADP- and collagen-induced aggregation. Platelet aggregation was not affected by the infusion of Ringer's solution or Ringer's acetate solution as compared to non-treated controls.
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Åberg M, Hedner U, Bergentz SE (1979) Effect of dextran on factor VIII (antihemophilic factor) and platelet function. Ann Surg 189:243–248
Ballinger WF, Murray GF, Morse EE (1966) Preliminary report of the use of hydroxy-ethyl starch in man. J Surg Res 6:180–183
Bergentz SE, Eiken O, Nilsson IM (1961) The effect of dextran on various molecular weights on the coagulation in dogs. Thromb Diath Haemorrh 6:15–24
Boon JC, Jesch F, Ring J, Messmer K (1976) Intravascular persistence of hydroxy-ethyl starch in man. Eur Surg Res 8:497–503
Born G (1962) Aggregation of blood platelets by ADP and its reversal. Nature 194:927–929
Buckhold DK, Pryor WH, Homer LD, Uddin D, Hickey T, DiSimone A (1978) Hemorrhagic shock treatment with hot intravenous fluid in dogs. J Trauma 18:726–729
Carbonne JV, Fürth RW, Scott R, Crosby WH (1954) A hemostatic defect associated with dextran infusion. Proc Soc Exp Biol Med 85:101–107
Carlin G, Saldeen T (1978) Influence of dextran 70 on the action of primary fibrinolysis inhibitor (α 2 -plasmin inhibitor). Thromb Res 12:681–684
Constantine JW (1967) Aggregation of guinea-pig platelets by adenosine diphosphate. Nature 210:162–164
Edwald RA, Eichelberger JW, Young AA, Weiss HJ, Crosby WH (1965) The effect of dextran on platelet factor 3 activity. In vitro and in vivo studies. Transfusion 5:109–114
Elmér O, Göransson G, Saku M, Bengmark S (1977) Influence of physiological saline, dextran 70, hydroxy-ethyl starch, degraded gelatin and fat emulsion on screen filtration pressure. Eur Surg Res 9:85–95
Evonuk E (1966) Hemodynamic and metabolic of infused low molecular weight dextran. Am J Physiol 212:514–518
Garjon AA, Cheng C, Lerner B, et al (1967) Hydroxy-ethyl starch (HES) and bleeding: an experimental investigation of its effect on haemostasis. J Trauma 7:757–766
Gregersen M, Usami S, Chien S (1965) Effects of plasma expanders on viscosity of human blood. Int Congr Physiol Sci, 23rd Tokyo Symp Spec Lect, p 98
Hogan JJ (1915) The intravenous use of colloidal (gelatin) solution in shock. Am Med Assoc 64:721–726
Kampen EJ van, Zijlstra WG (1961) Standardization of hemoglobinometry. Clin Chim Acta 6:538–544
Kaplan KL, Broekman MT, Chernoff A, Lesjnik GR, Drillings M (1978) Plateletα-granule proteins studies on release and subcellular localization. Blood 53:604–618
Lawson DH (1977) Intravenous fluids in medical in-patients. Br J Clin Pharmacol 4:299–303
Lindblad G, Falk J (1976) Konzentrationsverlauf von Hydroxyäthylstärke und Dextran in Serum und Lebergewebe von Kaninchen und die histopathologischen Folgen der Speicherung von Hydroxyäthylstärke. Infusionstherapie 3:301–303
Ludwig H, Stiebler H, Wolf B (1969) Hemostasis and gelatin infusion. Modified gelatins as plasma substitutes. Bibl Haematol 33:492–495
Lundsgaard-Hansen P, Riedwyl H, Hässig E (1967) Vergleich von Dextran und Gelatine als Plasmaersatzmittel. Anaesthesist 16:206–209
Mustard IF, Parkham MA, Kinlough-Rathbone RL, Perry DW, Regoeczi E (1978) Fibrinogen and ADP-induced platelet aggregation. Blood 52:453–466
Nilsson IM, Eiken O (1964) Further studies on the effect of dextran of various molecular weights on the coagulation mechanism. Thromb Diath Haemorrh 11:38–50
Proctor RP, Rapaport SI (1961) The partial thromboplastin time with kaolin. Am J Clin Pathol 36:212–219
Ring J, Seifert J, Messmer K, Brendel W (1976) Anaphylactoid reactions due to hydroxyethyl starch infusion. Eur Surg Res 8:389–399
Rock G, Wise P (1979) Plasma expansion during granulocyte procurement: cumulative effects of hydroxyethyl starch. Blood 53[6]:1156–1163
Rosse SW, Ebert RV (1959) Microelectrophoresis of blood platelets and the effect of dextran. J Clin Invest 38:155–158
Segal A (1964) The clinical use of dextran solution. Grune and Stratton, New York London
Serkes K, Lang S, Pareira J (1959) Efficacy of plasma and dextran compared to saline for fluid replacement following tourniquet shock. Surgery 45[4]:623–633
Shah D, Browner B, Newell J (1977) Cardiac output and pulmonary widge pressure. Its usefulness for fluid resuscitation of trauma patients. Arch Surg 112:1161–1164
Shatney CH, Deepika K, Militello PR, Majerus TC, Dawson RP (1983) Efficacy of hetastarch in the resuscitation of patients with multisystem trauma and shock. Arch Surg 118:804–809
Shires T (1979) Postoperative, post-traumatic management of fluids. Bull N Y Acad Med 55[2]:248–256
Smith JA, Norman JN (1982) The fluid of choice for resuscitation of severe shock. Br J Surg 69:702–705
Taketomi Y, Kuramoto A (1977) Ultrastructural studies on the surface coat of human platelets aggregated by polylysine and dextran. Thromb Haemostas 40:11–23
Thomson WL, Fukushima T, Rutherford R, Walton R (1979) Intravasale Persistenz, Gewebsspeicherung und Ausscheidung von Hydroxyäthylstäcke (HÄS). Infusionstherapie 6:151–155
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Supported by the Swedish Cancer Society (grant no. 98-B77-13XB77-133)
Supported by a fellowship from the A. Onassis Foundation
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Zoucas, E., Göransson, G. & Bengmark, S. Colloid-induced changes in bleeding following liver resection in the rat. Res. Exp. Med. 184, 251–258 (1984). https://doi.org/10.1007/BF01852384
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DOI: https://doi.org/10.1007/BF01852384