Summary
The high ascorbic acid concentration in the brain inhibits lipid peroxidation induced by various agents in rat brain microsomes. The physiological importance of the fact is discussed.
Similar content being viewed by others
References
H. Zalkin and A. L. Tappel, Archs. Biochem. Biophys.88, 113 (1960).
S. Bishayee and A. S. Balasubramanian, J. Neurochem.18, 909 (1971).
S. K. Sharma and C. R. Krishna Murti, J. Neurochem.15, 147 (1968).
S. K. Sharma and C. R. Krishna Murti, J. Neurochem.27, 299 (1976).
O. De Marchena, M. Guarnieri and G. McKhann, J. Neurochem.22, 773 (1974).
F. E. Hunter, A. Scott, Jr., P. E. Hoffsten, F. Guerra, J. Weinstein, A. Schneider, B. Schutz, J. Fink, L. Ford and E. Smith, J. biol. Chem.239, 604 (1964).
E. D. Wills, Biochem. J.113, 315 (1968).
A. Schaefer, M. Komlós and A. Seregi, Biochem. Pharmac.24, 1791 (1975).
A. Schaefer, A. Seregi and M. Komlós, Biochem. Pharmac.23, 2257 (1974).
K. M. Wilbur, F. Bernheim and O. W. Sharpio, Archs. Biochem. Biophys.24, 305 (1948).
R. O. Sinnhuber, T. C. Yu and T. C. Yu, Food Res.23, 626 (1958).
O. H. Lowry, M. J. Rosebrough, A. L. Farr and R. J. Randall, J. biol. Chem.196, 265 (1951).
R. P. Maickel, Analyt. Biochem.1, 498 (1960).
R. Rajalakshimi and A. J. Patel, J. Neurochem.15, 195 (1968).
G. Konat, J. Neurochem.20, 1247 (1973).
F. E. Hunter, A. Scott, Jr., P. E. Hoffsten, J. M. Gebicki, J. Weinstein and A. Schneider, J. biol. Chem.239, 614 (1964).
N. Sailer, in: Handbook of Neurochemistry, vol. 1, p. 325. Ed. A. Lajtha. Plenum Press, New York 1970.
B. Matkovics and R. Novák, Experientia33, 1574 (1977).
C. L. Moore and P. M. Strasberg, in: Handbook of Neurochemistry, vol. 3, p. 53. Ed. A. Lajtha. Plenum Press, New York 1970.
Author information
Authors and Affiliations
Additional information
We thank Miss Zs. Mergl for skilful technical assistance.
Rights and permissions
About this article
Cite this article
Seregi, A., Schaefer, A. & Komlós, M. Protective role of brain ascorbic acid content against lipid peroxidation. Experientia 34, 1056–1057 (1978). https://doi.org/10.1007/BF01915344
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01915344