Abstract
Rats were prepared with jugular catheters and assigned randomly to one of three groups: intravenous (IV) self-administration of cocaine, yoked administration of cocaine or vehicle. Rats experienced intermittent administration of cocaine (0.75 mg/kg per injection) or vehicle (0.1 ml/injection) for six test sessions, in accordance with the pattern of injections made by the self-administration group. Sensitization of motor activity between pre-and post-treatment challenges of cocaine (3 mg/kg, IV) was observed after both self- and yoked administration of cocaine but not in the yoked-vehicle group. These data indicate that sensitization as a consequence of drug self-administration may be an important factor in the etiology of addiction.
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Phillips, A.G., Di Ciano, P. Behavioral sensitization is induced by intravenous self-administration of cocaine by rats. Psychopharmacology 124, 279–281 (1996). https://doi.org/10.1007/BF02246669
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DOI: https://doi.org/10.1007/BF02246669