Abstract
Excessive administration of ammonium chloride to normal adult male rats receiving a diet adequate in vitamin D caused the development of osteoporosis. The osteoporosis was due to loss of bone substance and bone mineral associated with increased bone resorption.
Résumé
L'administration chronique de chlorure d ammonium à des rats adultes normaux, soumis à un régime contenant un taux approprié de vitamine D, provoque une ostéoporose. Celle-ci est provoquée par une perte de substance d'os et de minéral osseux, associée à l'augmentation de la résorption osseuse.
Zusammenfassung
Chronische Verabreichung von Ammoniumchlorid an normale ausgewachsene männliche Ratten, die eine entsprechende Vitamin-D-haltige Diät erhalten, verursacht die Entwicklung einer Osteoporose.
Die Osteoporose entsteht auf Grund eines Verlustes von Knochensubstanz und Knochenmineral, in Begleitung einer erhöhten Knochenresorption.
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Supported in part by a research grant from The Arthritis Foundation, New York Chapter, Inc. The author wishes to acknowledge generous support by Dr. J. Tobis, Chief, Division of Rehalbilitation Medicine at Montefiore Hospital and Medical Center.
Histological examination was performed in cooperation with Doctor H. Dorfman, Director of Laboratories, Hospital for Joint Diseases and Medical Center.
Technical help was furnished by Mr. M. Fein.
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Barzel, U.S. The effect of excessive acid feeding on bone. Calc. Tis Res. 4, 94–100 (1969). https://doi.org/10.1007/BF02279111
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DOI: https://doi.org/10.1007/BF02279111