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Reactions of melatonin with radicals in deoxygenated aqueous solution

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Abstract

Reactions of melatonin (N-acetyl-5-methoxytryptamine) with radiolytically generated radicals were studied. Reaction of melatonin with OH radicals is diffusion-controlled (k=1.2·1010 dm3 mol−1·s−1), the main (but not the only one) intermediate being the indolyl-type radical, while the rate constant for the reaction with hydrated electrons isk=4.3·108 dm3·mol−1·s−1. Melatonin is capable of scavenging tert-butanol radicals, while its reactivity towards polymer radicals of poly(acrylic acid) and poly(vinyl pyrrolidone) is very low.

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References

  1. B. Poeggeler, R. J. Reiter, D.-X. Tan, L.-D. Chen, L. C. Manchester, J. Pineal Res., 14 (1993) 151.

    CAS  Google Scholar 

  2. R. J. Reiter, Exp. Gerontology, 3–4 (1995) 199.

    Google Scholar 

  3. J. C. Scaiano, J. Pineal Res., 19 (1995) 189.

    CAS  Google Scholar 

  4. J. R. Reiter, Endocr. Res., 1 (1980) 109.

    CAS  Google Scholar 

  5. D. C. Klein, M. A. Namboodiri, D. A. Auerbach, Life Sci., 28 (1981) 1975.

    Article  CAS  Google Scholar 

  6. B. L. Myers, P. Badia, Neurosci. Behav. Revs., 19 (1995) 533.

    Google Scholar 

  7. R. J. Wurtman, I. Zhdanova, Lancet, 346 (1995) 1491.

    Article  CAS  Google Scholar 

  8. M. E. J. Attenburrow, B. A. Dowling, P. A. Sargent, A. L. Sharpley, P. J. Cowen. Psychopharmacology, 121 (1995) 503.

    Article  CAS  Google Scholar 

  9. J. B. Zawilska, M. Skalski, Wszechswiat, 97 (1996) 96.

    Google Scholar 

  10. W. Pierpaoli, W. Regelson, The Melatonin Miracle; Simon & Schuster, New York, 1995.

    Google Scholar 

  11. F. W. Turek, Nature, 379 (1996) 295.

    Article  CAS  Google Scholar 

  12. M. Abe, R. J. Reiter, P. B. Orhii, M. Hara, B. Poegeller, J. Pineal Res., 17 (1994) 94.

    CAS  Google Scholar 

  13. R. J. Reiter, A. Menendez-Pelaez, B. Poeggeler, D.-X. Tan, M. I. Pablos, D. Acuna-Castroviejo, Adv. Pineal Res., 8 (1994) 403.

    CAS  Google Scholar 

  14. J. R. Reiter, D. Melchiorri, E. Sewerynek, B. Poeggeler, L. Barlow-Walden, J. Chuang, G. G. Ortiz, D. Acuna-Castroviejo, J. Pineal Res., 18 (1995) 1.

    CAS  Google Scholar 

  15. D.-X. Tan, L.-D. Chen, B. Poeggeler, L. C. Manchester, R. J. Reiter, Endocrine J., 1 (1993) 57.

    Google Scholar 

  16. C. Pieri, M. Marra, F. Moroni, R. Recchioni, F. Marcheselli Life Sci., 15 (1994) PL271.

    Google Scholar 

  17. P. Ulanski, E. Bothe, K. Hildenbrand, J. M. Rosiak, C. von Sonntag, J. Chem. Soc., Perkin Trans. II, (1996) 13.

    Google Scholar 

  18. S. Karolczak, K. Hodyr, M. Polowinski, Radiat. Phys. Chem., 39 (1992) 1.

    CAS  Google Scholar 

  19. P. Kratochvil, Classical Light Scattering from Polymer Solutions. Elsevier, Amsterdam, 1987.

    Google Scholar 

  20. Polymer Handbook,J. Brandrup andE. H. Immergut (Eds), John Wiley & Sons, New York, 1975.

    Google Scholar 

  21. X. Shen, J. Lind, G. Merenyi, J. Phys. Chem., 91 (1987) 4403.

    Google Scholar 

  22. S. Goldstein, G. Czapski, Intern. J. Radiat. Biol., 46 (1984) 725.

    CAS  Google Scholar 

  23. M. Liphard, E. Bothe, D. Schulte-Frohlinde, Intern. J. Radiat. Biol., 58 (1990) 589.

    CAS  Google Scholar 

  24. G. V. Buxton, C. L. Greenstock, W. P. Helman, A. B. Ross, J. Phys. Chem. Ref. Data, 17 (1988) 513.

    CAS  Google Scholar 

  25. M. L. Posener, G. E. Adams, P. Wardman, R. B. Cundall, J. Chem. Soc., Faraday Trans. 1, 72 (1976) 2231.

    Google Scholar 

  26. S. Solar, N. Getoff, P. S. Surdhar, D. A. Armstrong, A. Singh, J. Phys. Chem.,95 (1991) 3639.

    Article  CAS  Google Scholar 

  27. S. V. Jovanovic, S. Steenken, J. Phys. Chem., 96 (1992) 6674.

    Article  CAS  Google Scholar 

  28. A. T. Al-Kazwini, P. O'Neill, G. E. Adams, R. B. Cundall, B. Jacquet, G. Lang, A. Junino, J. Phys. Chem., 94 (1990) 6666.

    Article  CAS  Google Scholar 

  29. M. Simic, P. Neta, E. Hayon, J. Phys. Chem., 73 (1969) 3794.

    CAS  Google Scholar 

  30. P. Ulanski, J. M. Rosiak, J. Radioanal. Nucl. Chem., 186 (1994) 315.

    CAS  Google Scholar 

  31. C. von Sonntag, E. Bothe, P. Ulanski, D. J. Deeble, Radiat. Phys. Chem., 46 (1995) 527.

    Google Scholar 

  32. P. Ulanski, E. Bothe, K. Hildenbrand, J. M. Rosiak, C. von Sonntag, Radiat. Phys. Chem., 46 (1995) 909.

    CAS  Google Scholar 

  33. P. Ulanski, E. Bothe, K. Hildenbrand, C. von Sonntag, J. M. Rosiak, Nukleonika, 42 (1997) 425.

    CAS  Google Scholar 

  34. J. M. Rosiak, J. Olejniczak, W. Pekala, Radiat. Phys. Chem., 26 (1990) 747.

    Google Scholar 

  35. G. Bartosz, R. Zadzinski, Wszechswiat, 97 (1996) 100.

    Google Scholar 

  36. C. von Sonntag The Chemical Basis of Radiation Biology, Taylor & Francis, London, 1987, p. 301.

    Google Scholar 

  37. K. Mennenga, M. Ueck, R. J. Reiter, J. Pineal Res., 10 (1991) 159.

    CAS  Google Scholar 

  38. A. Menendez-Pelaez, J. R. Reiter, J. Pineal Res., 15 (1993) 59.

    CAS  Google Scholar 

  39. A. Menendez-Pelaez, B. Poeggeler, R. J. Reiter, L. R. Barlow-Walden, M. I. Pablos, D.-X. Tan, J. Cell. Biochem., 53 (1993) 372.

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Applied Radiation Chemistry, Technical University of Ęódź, Wróblewskiego 15, PL-93-590, Ęódź, Poland

    P. Stasica, P. Ulanski & J. M. Rosiak

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  1. P. Stasica
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  2. P. Ulanski
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  3. J. M. Rosiak
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Stasica, P., Ulanski, P. & Rosiak, J.M. Reactions of melatonin with radicals in deoxygenated aqueous solution. J Radioanal Nucl Chem 232, 107–113 (1998). https://doi.org/10.1007/BF02383723

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  • DOI: https://doi.org/10.1007/BF02383723

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