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The effects of prostaglandin E2 in growing rats: Increased metaphyseal hard tissue and cortico-endosteal bone formation

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Summary

To assess the efficacy of PGE2 in inducingin vivo bone formation, graded doses of prostaglandins E2 were administered to 255 g rats. Histomorphometric analyses of selected sequential fluorescent-labeled bones of rats treated with 0,0.3, 1.0, 3, or 6 mg PGE2/kg/d for 21 days showed that the doses of PGE2 depressed longitudinal bone growth, increased growth cartilage thickness slightly, decreased degenerative cartilage cell size and cartilage cell production slightly, and increased proximal tibial metaphyseal hard-tissue mass markedly. Periosteal bone formation was depressed at the higher doses, and an early, slight depression in endosteal bone formation was also observed, along with a striking late increase in endosteal bone formation and in the formation of trabecular bone in the marrow cavity of the tibial shaft. The characteristics and magnitude of these responses were quite similar to those observed in our previous study of the effects of PGE2 on weanling rats except for the delayed increase in cortico-endosteal bone formation.

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Author notes

  1. K. Ueno

    Present address: Department of Orthopaedic Surgery, Niigata University School of Medicine, Niigata City, Japan

Authors and Affiliations

  1. Radiobiology Division, Department of Pharmacology, University of Utah School of Medicine, 84112, Salt Lake City, UT, USA

    W. S. S. Jee, K. Ueno & Y. P. Deng

  2. Neuropharmacology and Epileptology Division, Department of Physiology, University of Utah School of Medicine, 84108, Salt Lake City, UT, USA

    D. M. Woodbury

Authors
  1. W. S. S. Jee
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  2. K. Ueno
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  3. Y. P. Deng
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  4. D. M. Woodbury
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Jee, W.S.S., Ueno, K., Deng, Y.P. et al. The effects of prostaglandin E2 in growing rats: Increased metaphyseal hard tissue and cortico-endosteal bone formation. Calcif Tissue Int 37, 148–157 (1985). https://doi.org/10.1007/BF02554834

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