Abstract
Certain haplotypes at the major histocompatibility (B) complex (Mhc) of the chicken provide an easily demonstrated influence on tumor formation following infections with Marek's disease virus (MDV). Recognition that there is a second histocompatibility complex of genes in the chicken,Rfp-Y, comprised ofMhc class I and class II genes, some of which are at least transcribed, evokes the question of whether this gene complex might also influence the outcome of MDV infections. To test this hypothesis, pedigree-hatched chicks in families from the originalRfp-Y-defining stock in which threeRfp-Y and twoB system haplotypes are segregating were challenged with the RB1B strain of MDV. Birds with theY 3/Y 3 genotype were found to have 2.3 times the risk of developing a tumor compared with birds with otherRfp-Y genotypes combined (P<0.02). Additionally, birds carrying theB R9/B 11 genotype had 2.3 times the risk of tumor formation, relative to birds with theB 11/B 11 genotype (P<0.02). We found no evidence for an interaction between genotypes within theB andRfp-Y systems. These data provide evidence thatRfp-Y haplotypes, as well asB haplotypes, can significantly influence the outcome of infection with MDV.
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Wakenell, P.S., Miller, M.M., Goto, R.M. et al. Association between theRfp-Y haplotype and the incidence of Marek's disease in chickens. Immunogenetics 44, 242–245 (1996). https://doi.org/10.1007/BF02602552
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DOI: https://doi.org/10.1007/BF02602552