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Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood?

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Abstract

Depression is the major psychiatric ailment of our times, afflicting ∼20% of the population. Despite its prevalence, the pathophysiology of this complex disorder is not well understood. In addition, although antidepressants have been in existence for the past several decades, the mechanisms that underlie their therapeutic effects remain elusive. Building evidence implicates a role for the plasticity of specific neuro-circuitry in both the pathophysiology and treatment of depression. Damage to limbic regions is thought to contribute to the etiology of depression and antidepressants have been reported to reverse such damage and promote adaptive plasticity. The molecular pathways that contribute to the damage associated with depression and antidepressant-mediated plasticity are a major focus of scientific enquiry. The transcription factor cyclic AMP response element binding protein (CREB) and the neurotrophin brain-derived neurotrophic factor (BDNF) are targets of diverse classes of antidepressants and are known to be regulated in animal models and in patients suffering from depression. Given their role in neuronal plasticity, CREB and BDNF have emerged as molecules that may play an important role in modulating mood. The purpose of this review is to discuss the role of CREB and BDNF in depression and as targets/mediators of antidepressant action.

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Abbreviations

ATF:

Activating transcription factor

BDNF:

brain-derived neurotrophic factor

CRE:

cAMP response element

CREB:

cyclic AMP response element binding protein

CREM:

cAMP response element modulator

ECS:

electroconvulsive seizure therapy

HPA:

hypothalmo-pituitary-adrenocortical

NPY:

neuropeptide Y

PFC:

prefrontal cortex

PKA:

protein kinase A

VTA:

ventral tegmental area

References

  • Alderson R F, Alterman A L, Barde Y A and Lindsay R.M 1990Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture;Neuron 5 297–306

    Article  CAS  PubMed  Google Scholar 

  • Alfonso J, Frick L R, Silberman D M, Palumbo M L, Genaro A M and Frasch AC 2006 Regulation of Hippocampal Gene Expression is Conserved in Two Species Subjected to Different Stressors and Antidepressant Treatments;Biol. Psych. 59 244–251

    Article  CAS  Google Scholar 

  • Arthur J S, Fong A L, Dwyer J M, Davare M, Reese E, Obrietan K and Impey S 2004 Mitogen- and stress-activated protein kinase 1 mediates cAMP response element-binding protein phosphorylation and activation by neurotrophins;J. Neurosci. 24 4324–4332

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bramham C R and Messaoudi E 2005 BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis;Prog. Neurobiol. 76 99–125

    Article  CAS  PubMed  Google Scholar 

  • Bremner J D, Randall P and Scott T M 1995 MRI-based measurement of hippocampal volume in patients with combat related posttraumatic stress disorder;Am. J. Psychiatry 152 973–981

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Briley M 2000Understanding antidepressants (Londona: Martin Dunitz)

    Google Scholar 

  • Bueller J A, Aftab M, Sen S, Gomez-Hassan D, Burmeister M and Zubieta J K 2006 BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects;Biol. Psychiatry 59 812–815

    Article  CAS  PubMed  Google Scholar 

  • Carlezon W A Jr, Thome J, Olson V G, Lane-Ladd S B, Brodkin E S, Hiroi N, Duman R S, Neve R L and Nestler E J 1998 Regulation of cocaine reward by CREB;Science 282 2272–2275

    Article  CAS  PubMed  Google Scholar 

  • Carroll, Curtis G C and Mendels J 1976 Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction;Arch. Gen. Psychiatry 33 1039–1044

    Article  CAS  PubMed  Google Scholar 

  • Cesare D D, Fimia G M and Sassone-Corsi P 1999 Signalling routes to CREM and CREB: plasticity in transcriptional activation;TIBS 24 281–285

    PubMed  Google Scholar 

  • Chen A C, Shirayama Y, Shin K H, Neve R L and Duman RS 2001 a Expression of the cAMP response element binding protein (CREB) in hippocampus produces an antidepressant effect;Biol. Psychiatry 49 753–762

    Article  CAS  PubMed  Google Scholar 

  • Chen B, Dowlatshahi D, MacQueen G M, Wang J F and Young L T 2001b Increased hippocampal BDNF immunoreactivity in subjects treated with antidepressant medication;Biol. Psychiatry 50 260–265

    Article  CAS  PubMed  Google Scholar 

  • Conti A C, Cryan J F, Dalvi A, Lucki I and Blendy J A 2002 cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioural or endocrine responses to antidepressant drugs;J. Neurosci 22 3236–3268

    Article  Google Scholar 

  • Czeh B, Michaelis T, Watanabe T, Frahm J, de BiurrunG, van KampenM, Bartolomucci A and Fuchs E 2001 Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine;Proc. Natl. Acad. Sci. USA 98 12796–12780

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dagestad G, Kuipers S D, Messaoudi E and Bramham C R 2006 Chronic fluoxetine induces region-specific changes in translation factor eIF4E and eEF2 activity in the rat brain;Eur. J. Neurosci. 23 2814–2818

    Article  PubMed  Google Scholar 

  • Dias B G, Banerjee S B, Duman R S and Vaidya V A 2003 Differential regulation of brain derived neurotrophic factor transcripts by antidepressant treatments in the adult rat brain;Neuropharmacology 45 553–563

    Article  CAS  PubMed  Google Scholar 

  • Dowlatshahi D, MacQueen G M, Wang J Fand Young L T 1998 Increased temporal cortex CREB concentrations and anti-depressant treatment in major depression;Lancet 352 1754–755

    Article  CAS  PubMed  Google Scholar 

  • Drevets W C, Price J L, Simpson J R Jr, Todd R D, Reich T, Vannier M and Raichle M E 1997 Subgenual prefrontal cortex abnormalities in mood disorders;Nature (Lonodon) 386 824–827

    Article  CAS  Google Scholar 

  • Dwivedi Y, Rizavi H S, Conley R R and Pandey G N 2006 ERK MAP kinase signalling in post-mortem brain of suicide subjects: differential regulation of upstream Raf kinases Raf-1 and B-Raf;Mol. Psychiatry 11 86–98

    Article  CAS  PubMed  Google Scholar 

  • Egan M F, Kojima M, Callicott J H, Goldberg T E, Kolachana B S, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B and Weinberger D R 2003 The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function;Cell 112 257–269

    Article  CAS  PubMed  Google Scholar 

  • Eisch A J, Bolanos C A, de Wit J, Simonak R D, Pudiak C M, Barrot M, Verhaagen J and Nestler E J 2003 Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression;Biol. Psychiatry 54 994–1005

    Article  CAS  PubMed  Google Scholar 

  • Farmer J, Zhao X, van Praag H, Wodtke K, Gage F H and Christie B R 2004 Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague- Dawley rats in vivo;Neuroscience 124 71–79

    Article  CAS  PubMed  Google Scholar 

  • Fujioka T, Fujioka A and Duman R S 2004 Activation of cAMP signalling facilitates the morphological maturation of newborn neurons in adult hippocampus;J. Neurosci. 24 319–328

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fumagalli F, Molteni R, Calabrese F, Frasca A, Racagni G and Riva M A 2005 Chronic fluoxetine administration inhibits extracellular signal-regulated kinase 1/2 phosphorylation in rat brain;J. Neurochem. 93 1551–1560

    Article  CAS  PubMed  Google Scholar 

  • Giachino C, De Marchis S, Giampietro C, Parlato R, Perroteau I, Schutz G, Fasolo A and Peretto P 2005 cAMP response element- binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb;J. Neurosci. 25 10105–10118

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gould E and Tanapat P 1999 Stress and hippocampal neurogenesis;Biol. Psychiatry 46 1472–1479

    Article  CAS  PubMed  Google Scholar 

  • Gueorguiev V D, Cheng S Y and Sabban E L 2006 Prolonged activation of cAMP-response element-binding protein and ATF-2 needed for nicotine-triggered elevation of tyrosine hydroxylase gene transcription in PC12 cells;J. Biol. Chem. 281 10188–10195

    Article  CAS  PubMed  Google Scholar 

  • Hansel D E, Eipper B A and Ronnett G V 2001 Neuropeptide Y functions as a neuroproliferative factor;Nature (London) 410 940–944

    Article  CAS  Google Scholar 

  • Hatalski C G and Baram T Z 1997 Stress-induced transcriptional regulation in the developing rat brain involves increased cyclic adenosine 3`,5`-monophosphate-regulatory element binding activity;Mol. Endocrinol. 11 2016–2024

    CAS  PubMed  Google Scholar 

  • Hoefer M M and Barde Y A 1988 Brain-derived neurotrophic factor prevents neuronal death in vivo;Nature (London) 331 261–262

    Article  Google Scholar 

  • Hwang J P, Tsai S J, Hong C J, Yang C H, Lirng J F and Yang Y M 2005 The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression;Neurobiol. Aging (Epub ahead of print).

  • Itoh T, Tokumura M and Abe K 2004 Effects of rolipram, a phosphodiesterase 4 inhibitor, in combination with imipramine on depressive behaviour, CRE-binding activity and BDNF level in learned helplessness rats;Eur. J. Pharmacol. 498 135–142

    Article  CAS  PubMed  Google Scholar 

  • Itoi K, Horiba N, Tozawa F, Sakai Y, Sakai K, Abe K, Demura H and Suda T 1996 Major role of 3`,5`-cyclic adenosine monophosphate-dependent protein kinase A pathway in corticotropin-releasing factor gene expression in the rat hypothalamus in vivo;Endocrinology 137 2389–2396

    Article  Google Scholar 

  • Jacobson L and Sapolsky R 1991 The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis;Endocrinol. Rev 12 118–134

    Article  CAS  Google Scholar 

  • Johannessen M, Delghandi M P and Moens U 2004 What turns CREB on?;Cellular Signalling 16 1211–1227

    Article  CAS  PubMed  Google Scholar 

  • Kafitz K W, Rose C R, Thoenen H and Konnerth A 1999 Neurotrophin-evoked rapid excitation through TrkB receptors;Nature (London) 401 918–921

    Article  CAS  Google Scholar 

  • Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G and Aubry J M 2002 Decreased serum brain-derived neurotrophic factor levels in major depressed patients;Psychiatry Res. 109 143–148

    Article  CAS  PubMed  Google Scholar 

  • Kaufman J, Yang B Z, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal J H and Gelernter J 2006 Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children;Biol. Psychiatry 59 673–680

    Article  CAS  PubMed  Google Scholar 

  • Kleim J A, Chan S, Pringle E, Schallert K, Procaccio V, Jimenez R and Cramer S C 2006 BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex;Nat. Neurosci. (Epub ahead of print)

  • Koponen E, Rantamaki T, Voikar V, Saarelainen T, MacDonald E and Castren E 2005 Enhanced BDNF signalling is associated with an antidepressant-like behavioural response and changes in brain monoamines;Cell. Mol. Neurobiol. 25 973–980

    Article  PubMed  Google Scholar 

  • Lyons W E, Mamounas L A, Ricaurte G A, Coppola V, Reid S W, Bora S H, Wihler C, Koliatsos V E and Tessarollo L 1999 Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities;Proc. Natl. Acad. Sci. USA 96 15239–15244

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Malberg J E and Blendy J A 2005 Antidepressant action: to the nucleus and beyond;TIPS 26 631–638

    CAS  PubMed  Google Scholar 

  • Masquilier D and Sassone-Corsi P 1992 Transcriptional cross-talk: nuclear factors CREM and CREB bind to AP-1 sites and inhibit activation by Jun;J. Biol. Chem. 267 22460–22466

    CAS  PubMed  Google Scholar 

  • Mizuno K and Giese K P 2005 Hippocampus-dependent memory formation: do memory type-specific mechanisms exist?;J. Pharmacol. Sci. 98 191–197

    Article  CAS  PubMed  Google Scholar 

  • Monteggia L M, Barrot M, Powell C M, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene R W and Nestler E J 2004 Essential role of brain-derived neurotrophic factor in adult hippocampal function;Proc. Natl. Acad. Sci. USA 20 10827–10832

    Article  Google Scholar 

  • Monteggia L M, Luikart B, Barrot M, Theobold D, Malkovska I, Nef S, Parada L F and Nestler E J 2006 Brain-Derived Neurotrophic Factor Conditional Knockouts Show Gender Differences in Depression-Related Behaviours;Biol. Psych. (Epub ahead of print).

  • Montminy M 1997 Transcriptional regulation by cyclic AMP;Annual. Rev. Biochem. 66 807–822

    Article  CAS  Google Scholar 

  • Nakagawa S, Kim J, Lee R Malberg J E, Chen J, Steffen C, Zhang Y, Nestler E J and Duman R S 2002 Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein;J. Neurosci. 22 3673–3682

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nestler E J and Carlezon W A Jr 2006 The mesolimbic dopamine reward circuit in depression;Biol. Psychiatry (Epub ahead of print)

    Article  CAS  PubMed  Google Scholar 

  • Nestler E J, Terwilliger R Z and Duman R S 1989 Chronic antidepressant administration alters the subcellular distribution of cyclic AMP-dependent protein kinase in rat frontal cortex;J. Neurochem. 53 1644–1647

    Article  CAS  PubMed  Google Scholar 

  • Newton S S, Thome J, Wallace T L, Shirayama Y, Schlesinger L, Sakai N, Chen J, Neve R, Nestler E J and Duman R S 2002 Inhibition of cAMP response element binding protein or dynorphin in the nucleus accumbens produces an antidepressant- like effect;J. Neurosci. 22 10883–10890

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F and Kennedy J L 2002 The brain-derived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study;Am. J. Hum. Genet. 71 651–655

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nibuya M, Morinobu S and Duman R S 1995 Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments;J. Neurosci. 15 7539–7547

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nibuya M, Nestler E J and Duman R S 1996 Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus;J. Neurosci. 16 2365–2372

    Article  Google Scholar 

  • Noble R E 2005 Depression in women;Metabolism. 54 49–52

    Article  CAS  PubMed  Google Scholar 

  • Pandey S C 2003 Anxiety and alcohol abuse disorders: a common role for CREB and its target, the neuropeptide Y gene;Trends Pharmacol. Sci. 24 456–460

    Article  CAS  PubMed  Google Scholar 

  • Pencea V, Bingaman K D, Wiegand S J and Luskin MB 2001 Infusion of brain-derived neurotrophic factor into the lateral ventricles of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus;J. Neurosci. 21 6706–6717

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pham K, Nacher J, Hof P R and McEwan B S 2003 Repeated restraint stress suppresses neurogenesis and induces biphasic PSA-NCAM expression in the adult rat dentate gyrus;Eur J. Neurosci. 17 879–886

    Article  PubMed  Google Scholar 

  • Pliakas A M, Carlson R R, Neve R L, Konradi C, Nestler E J and Carlezon W A Jr 2001 Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens;J. Neurosci. 21 7397–7403

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rajkowska G 2000 Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells;Biol. Psychiatry 48 766–777

    Article  CAS  PubMed  Google Scholar 

  • Rasmusson A M, Shi L and Duman R 2002 Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock;Neuropsychopharmacology 271 133–142

    Article  Google Scholar 

  • Saarelainen T, Pussinen R, Koponen E, Alhonen L, Wong G, Sirviö J and Castrén E 2000 Transgenic mice overexpressing truncated trkB neurotrophin receptors in neurons have impaired longterm spatial memory but normal hippocampal LTP;Synapse 38 102–104

    Article  CAS  PubMed  Google Scholar 

  • Saarelainen T, Hendolin P, Lucas G, Koponen E, Sairanen M, MacDonald E, Agerman K, Haapasalo A, Nawa H, Aloyz R, Ernfors P and Castren E 2003 Activation of the TrkB neurotrophin receptor is induced by antidepressant drugs and is required for antidepressant-induced behavioural effects;J. Neurosci. 23 349–357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sairanen M, Lucas G, Ernfors P, Castren M and Castren E 2005 Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus;J. Neurosci. 25 1089–1094

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C and Hen R 2003 Requirement of hippocampal neurogenesis for the behavioural effects of antidepressants;Science 301 805–809

    Article  CAS  PubMed  Google Scholar 

  • Sheline Y I, Wang P W, Gado M H, Csernansky J G and Vannier M W 1996 Hippocampal atrophy in recurrent major depression;Proc. Natl. Acad. Sci. USA 93 3908–3913

    Article  Google Scholar 

  • Sheline Y I, Gado M H and Kraemer H C 2003 Untreated depression and hippocampal volume loss;Am. J. Psychiatry 160 1516–1518

    Article  PubMed  Google Scholar 

  • Shelton R C 2000 Cellular mechanisms in the vulnerability to depression and response to antidepressants;Psychiatr. Clin. North. Am. 23 713–729

    Article  CAS  PubMed  Google Scholar 

  • Shirayama Y, Chen AC Nakagawa S, Russell D S and Duman R S 2002 Brain-derived neurotrophic factor produces antidepressant effects in behavioural models of depression;J. Neurosci. 22 3251–3261

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Siuciak J A, Lewis D R, Weigand S J and Lindsay RM 1997 Antidepressant-like effect of brain-derived neurotrophic factor (BDNF);Pharmacol. Biochem. Behav. 56 131–137

    Article  CAS  PubMed  Google Scholar 

  • Smith M A, Makino S, Kventnansky R and Post R M 1995 Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus;J. Neurosci. 15 1768–1777

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Song L, Che W, Min-Wei W, Murakami Y and Matsumoto K 2006 Impairment of the spatial learning and memory induced by learned helplessness and chronic mild stress;Pharmacol. Biochem. Behav. 83 186–193

    Article  CAS  PubMed  Google Scholar 

  • Strauss J, Barr C L, George C J, Devlin B, Vetro A, Kiss E, Baji I, King N, Shaikh S, Lanktree M, Kovacs M and Kennedy J L 2005 Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample;Mol. Psych. 10 861–867

    Article  CAS  Google Scholar 

  • Tabuchi A, Sakaya H, Kisukeda T, Fushiki H and Tsuda M 2002 Involvement of an upstream stimulatory factor as well as cAMP-responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I;J. Biol. Chem. 277 35920–35931

    Article  CAS  PubMed  Google Scholar 

  • Tardito D, Perez J, Tiraboschi E, Musazzi L, Racagni G and Popoli M 2006 Signalling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview;Pharmacol. Rev. 58 115–134

    Article  CAS  PubMed  Google Scholar 

  • Thoenen H 1995 Neurotrophins and neuronal plasticity;Science 270 593–598

    Article  CAS  PubMed  Google Scholar 

  • Thome J, Sakai N, Shin K, Steffen C, Zhang Y J, Impey S, Storn D and Duman R S 2000 cAMP response element-mediated gene transcription is upregulated by chronic antidepressant treatment;J. Neurosci. 20 4030–4036

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Timmusk T, Palm K, Metsis M, Reintam T, Paalme V, Saarma M and Persson H 1993 Multiple promoters direct the tissue-specific expression of the rat BDNF gene;Neuron 10 475–489

    Article  CAS  PubMed  Google Scholar 

  • Tiraboschi E, Tardito D, Kasahara J, Moraschi S, Pruneri P, Gennarelli M, Racagni G and Popoli M 2004 Selective phosphorylation of nuclear CREB by fluoxetine is linked to activation of CaM kinase IV and MAP kinase cascades;Neuropsychopharmacology 29 1831–1840

    Article  CAS  PubMed  Google Scholar 

  • Tsankova N M, Berton O, Renthal W, Kumar A, Neve R L and Nestler E J 2006 Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action;Nat. Neurosci. 9 519–525

    Article  CAS  PubMed  Google Scholar 

  • Tyler W J, Perrett S P and Pozzo-Miller L D 2002 The role of neurotrophins in neurotransmitter release;Neuroscientist 8 524–531

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tyler W J, Alonso M, Bramham C R and Pozzo-Miller L D 2002 From acquisition to consolidation: on the role of brain-derived neurotrophic factor signalling in hippocampal-dependent learning;Learn Mem. 9 224–237

    Article  PubMed  Google Scholar 

  • Vaidya V A and Duman R S 2001 Depression - emerging insights from neurobiology;Br. Med. Bull. 57 61–79

    Article  CAS  PubMed  Google Scholar 

  • Vaidya V A, Siuciak J A, Du F and Duman R S 1999 Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures;Neuroscience 89 157–166

    Article  CAS  PubMed  Google Scholar 

  • Valverde O, Mantamadiotis T, Torrecilla M, Ugedo L, Pineda J, Bleckmann S, Gass P, Kretz O, Mitchell J M, Schutz G and Maldonado R 2004 Modulation of anxiety-like behaviour and morphine dependence in CREB-deficient mice;Neuropsychopharmacology 29 1122–1133

    Article  CAS  PubMed  Google Scholar 

  • Vyas A, Mitra R, Shankaranarayana Rao B S and Chattarji S 2002 Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons;J. Neurosci. 22 6810–6818

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wallace T L, Stellitano K E, Neve R L and Duman R S 2004 Effects of cyclic adenosine monophosphate response element binding protein overexpression in the basolateral amygdala on behavioural models of depression and anxiety;Biol. Psychiatry 56 151–160

    Article  CAS  PubMed  Google Scholar 

  • Watanabe Y, Gould E and McEwan B S 1992a Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons;Brain Res. 588 341–345

    Article  CAS  PubMed  Google Scholar 

  • Watanabe Y, Gould E, Daniels D C, Cameron H and McEwan B S 1992b Tianeptine attenuates stress-induced morphological changes in the hippocampus;Eur. J. Pharmacol. 222 157–162

    Article  CAS  PubMed  Google Scholar 

  • Zubenko G S, Maher B, Hughes H B 3rd, Zubenko W N, Stiffler J S, Kaplan B B and Marazita M L 2003 Genome-wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early-onset, major depression;Am. J. Med. Genet. B Neuropsychiatr. Genet. 123 1–18

    Article  Google Scholar 

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Nair, A., Vaidya, V.A. Cyclic AMP response element binding protein and brain-derived neurotrophic factor: Molecules that modulate our mood?. J. Biosci. 31, 423–434 (2006). https://doi.org/10.1007/BF02704114

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