Abstract
We report cloning and some features of a novel human gene,MATH2, which encodes a protein of 337 amino acid residues with a basic helix-loop-helix domain and exhibits 98% similarity to mouseMath2. Results of Northern blot analysis revealed two transcripts of theMATH2 gene of 1.7 kb and 2.4 kb in human brain. We localizedMATH2 to chromosome 7 at 7p14-15 by matching with the Human Genome Sequence Database. HumanMATH2 and mouseMath2 may have the same functions in the nervous system.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Akazawa C., Ishibashi M., Shimizu C., Nakanishi S. and Kageyama R. 1995 A mammalian basic helix-loop-helix factor structurally related to the product ofDrosophila proneural geneatonal is a positive transcriptional regulator expressed in the developing nervous system.J. Biol. Chem. 270, 8730–8738.
Bartholoma A. and Nave K. A. 1994 Nex-1: a novel brain-specific basic helix-loop-helix protein with autoregulation and sustained expression in mature cortical neurons.Mech. Dev. 48, 217–228.
Casarosa S., Fode C. and Guillemot F. 1999 MASH1 regulates neurogenesis in the ventral telencephalon.Development 126, 525–534.
Guillemot F. and Joyner A. L. 1993 Dynamic expression of the murine achaete-scute homologue MASH1 in the developing nervous system.Mech. Dev. 42, 171–185.
Ishibashi M., Moriyoshi K., Sasai Y., Shiota K., Nakanishi S. and Kageyama R. 1994 Persistent expression of basic helix-loop-helix factor HES1 prevents mammalian neural differentiation in the central nervous system.EMBO J. 13, 1799–1805.
Jarman A. P., Grau Y., Jan L. Y. and Jan Y. N. 1993Atonal is a proneural gene that directs chordotonal organ formation in theDrosophila peripheral nervous system.Cell 73, 1307–1321.
Kozak M. 1987 An analysis of 5−noncoding sequence from 699 vertebrate messenger RNAs.Nucl. Acids Res. 15, 8125–8148.
Lo L. C., Johnson J. E., Wuenschell C. W., Saito T. and Anderson D. J. 1991 Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neuro crest cells.Genes Dev. 5, 1524–1537.
McCormick M. B., Tamimi R. M., Snider L., Asakura A., Bergstrom D.and Tapscott S. J. 1996NEUROD2 andNEUROD3: Distinct expression patterns and transcriptional activation potentials within theNEUROD gene family.Mol. Cell. Biol. 16, 5792–5800.
Naya F. J., Stellrecht C. M. and Tsai M. J. 1995 Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.Genes Dev. 9, 1009–1019.
Sasai Y., Kageyama R., Tagawa Y., Shigemoto R. and Nakanishi S. 1992 Two mammalian basic helix-loop-helix factors structurally related toDrosophila hairy and Enhancer of split.Genes Dev. 6, 2620–2634.
Shimizu C., Akazawa C., Nakanishi S. and Kageyama R. 1995 MATH2, a mammalian basic helix-loop-helix factor structurally related to the product ofDrosophila proneural geneatonal, is specifically expressed in the nervous system.Eur. J. Biochem. 229, 239–248.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Guo, L., Jiang, M., Ma, Y. et al. Cloning, chromosome localization and features of a novel human gene,MATH2 . J Genet 81, 13–17 (2002). https://doi.org/10.1007/BF02715865
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02715865