Abstract
Using a homologous competition of54Mn-transferrin with Mntransferrin and65Zn-transferrin with Zn-transferrin, it was found that on the plasma membrane of lactating mouse mammary gland cells there are receptor binding Mn-transferrin and Zn-transferrin. The heterologous competition between labeled and nonlabeled Fe-transferrin, Mn-transferrin and Zn-transferrin, as well as almost equal affinity constants of cellular receptors toward the three metals by competition of Fe-transferrin suggests that one and the same receptor accepts all three metals from the transferrin molecule.
The cell receptors therefore possess a polymetal binding function. A model and a mechanism for regulation of the transport metal flow toward the mammary gland cell acting like “automated switching over” are proposed.
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Moutafchiev, D., Sirakov, L. & Bontchev, P. The competition between transferrins labeled with59Fe,65Zn, and54Mn for the binding sites on lactating mouse mammary gland cells. Biol Trace Elem Res 61, 181–191 (1998). https://doi.org/10.1007/BF02784029
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DOI: https://doi.org/10.1007/BF02784029