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Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women

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Abstract

Background

A cohort study for Caucasians aged 65 years or older demonstrated a marked breast cancer risk reduction for those with theCC genotype oftransforming growth factor B1 (TGF B1) T29C polymorphism. This is a prevalent case-control study to examine the reported risk reduction for Japanese women.

Patients and Methods

A total of 232 histologically diagnosed breast cancer patients who visited Aichi Cancer Center Hospital between June 1999 and March 2000 were enrolled. The controls were 172 female outpatients without cancer at the same hospital. DNA was extracted from peripheral blood, andTGF B1 genotype was determined by PCR-CTPP.

Results

The genotype frequency was 23.7% forTT, 49.2% forTC, and 27.1% forCC among controls, and 28.9%, 46.1%, and 25.0%, respectively, among cases. Age-adjusted odds ratio (OR) relative to theTT genotype was 0.81 (95% confidence interval, 0.50-1.31) for theTC genotype and 0.77 (0.45-1.34) for theCC genotype. For premenopausal women, theCC genotype was significantly associated with reduced risk of breast cancer in comparison with theTT genotype (OR =0.45, 0.20-0.98). The association was not observed for postmenopausal women (OR = 1.40, 0.64-3.08).

Conclusion

The present study showed risk reduction for Japanese premenopausal women with theCC genotype, but not for postmenopausal Japanese women.

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Abbreviations

TGF B1 :

Transforming growth factor B1

PCR-CTPP:

Polymerase chain reaction with confronting two-pair primers

OR:

Odds ratio

TGF-β:

Transforming growth factor-β

Cl:

Confidence interval

BMI:

Body mass index

ER:

Estrogen receptor

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Authors and Affiliations

  1. Division of Epidemiology and Prevention, Aichi Cancer Center, Japan

    Asahi Hishida, Nobuyuki Hamajima, Keitaro Matsuo, Kaoru Hirose & Kazuo Tajima

  2. First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Japan

    Asahi Hishida & Nobuhiko Emi

  3. Department of Breast Surgery, Aichi Cancer Center, Japan

    Hiroji Iwata, Mitsuhiro Mizutani, Takuji Iwase & Shigeto Miura

  4. Nagoya University Graduate School of Medicine, Japan

    Keitaro Matsuo

Authors
  1. Asahi Hishida
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  2. Hiroji Iwata
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Correspondence to Asahi Hishida.

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Reprint requests to Asahi Hishida, First Department of Internal Medicine, Nagoya University Graduate School of Medicine, Tsurumaicho 65, Showa-ku, Nagoya 466-8550, Japan

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Hishida, A., Iwata, H., Hamajima, N. et al. Transforming growth factor B1 T29C polymorphism and breast cancer risk in Japanese women. Breast Cancer 10, 63–69 (2003). https://doi.org/10.1007/BF02967627

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  • DOI: https://doi.org/10.1007/BF02967627

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