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The mechanisms of aquaporin control in the renal collecting duct

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Book cover Reviews of Physiology Biochemistry and Pharmacology

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 141))

Abstract

The antidiuretic hormone arginine-vasopressin (AVP) regulates water reabsorption in renal collecting duct principal cells. Central to its antidiuretic action in mammals is the exocytotic insertion of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the apical membrane of principal cells, an event initiated by an increase in cAMP and activation of protein kinase A. Water is then reabsorbed from the hypotonic urine of the collecting duct. The water channels aquaporin-3 (AQP3) and aquaporin-4 (AQP4), which are constitutively present in the basolateral membrane, allow the exit of water from the cell into the hypertonic interstitium. Withdrawal of the hormone leads to endocytotic retrieval of AQP2 from the cell membrane. The hormone-induced rapid redistribution between the interior of the cell and the cell membrane establishes the basis for the short term regulation of water permeability. In addition water channels (AQP2 and 3) of principal cells are regulated at the level of expression (long term regulation).

This review summarizes the current knowledge on the molecular mechanisms underlying the short and long term regulation of water channels in principal cells. In the first part special emphasis is placed on the proteins involved in short term regulation of AQP2 (SNARE proteins, Rab proteins, cytoskeletal proteins, G proteins, protein kinase A anchoring proteins and endocytotic proteins). In the second part, physiological and pathophysiological stimuli determining the long term regulation are discussed.

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References

  • Abrami L, Simon M, Rousselet G, Berthonaud V, Buhler JM, Ripoche P (1994) Sequence and functional expression of an amphibian water channel, FA-CHIP: a new member of the MIP family. Biochim Biophys Acta 1192:147–151

    PubMed  CAS  Google Scholar 

  • Abrami L, Capurro C, Ibarra C, Parisi M, Buhler JM, Ripoche P (1995) Distribution of mRNA encoding the FA-CHIP water channel in amphibian tissues: effects of salt adaptation. J Membrane Biol 143:199–205

    CAS  Google Scholar 

  • Ahnert-Hilger G, Mach W, Fohr KJ, Gratzl M (1989) Poration by alpha-toxin and streptolysin O: an approach to analyze intracellular processes. Methods Cell Biol 31:63–90

    PubMed  CAS  Google Scholar 

  • Ahnert-Hilger G, Schäfer T, Spicher K, Grund C, Schultz G, Wiedenmann B (1994) Detection of G protein heterotrimers on large dense core and small synaptic vesicles of neuroendocrine and neuronal cells. Eur J Cell Biol 65:26–28

    PubMed  CAS  Google Scholar 

  • Ahnert-Hilger G, Nürnberg B, Exner T, Schäfer T, Jahn R (1998) The heterotrimeric G protein Go2 regulates catecholamine uptake by secretory vesicles. EMBO J 17:406–413

    PubMed  CAS  Google Scholar 

  • Aktories K (1997) Rho proteins: targets for bacterial toxins. Trends Microbiol 5:282–288

    PubMed  CAS  Google Scholar 

  • Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE (1993) The human thyrotropin receptor activates G-proteins Gs and Gq/11. J Biol Chem 269:13733–13735

    Google Scholar 

  • Ämmälä C, Ashcroft FM, Rorsman P (1993) Calcium-independent potentiation of insulin release by cyclic AMP in single β cells. Nature 363:356–358

    PubMed  Google Scholar 

  • Ardaillou N, Placier S, Zhao J, Baudouin B, Ardaillou R (1998) Characterization or B2-bradykinin receptors in rabbit principal cells of the collecting duct. Exp Nephrol 6:534–541

    PubMed  CAS  Google Scholar 

  • Aridor M, Rajmilevich G, Beaven MA, Sagi-Eisenberg R (1993) Activation of exocytosis by the heterotrimeric G protein Gi3. Science 262:1569–1572

    PubMed  CAS  Google Scholar 

  • Aridor M, Balch WE (1999) Integration of cytoplasmic reticulum signaling in health and disease. Nat Med 5:745–751

    PubMed  CAS  Google Scholar 

  • Aspenström P (1999) The Rho GTPases have multiple effects on the actin cytoskeleton. Exp Cell Res 246:20–25

    PubMed  Google Scholar 

  • Banky P, Huang LJ, Taylor SS (1998) Dimerization/docking domain of the type Ialpha regulatory subunit of cAMP-dependent protein kinase. Requirements for dimerization and docking are distinct but overlapping. J Biol Chem 273:35048–35055

    PubMed  CAS  Google Scholar 

  • Barth H, Hofmann F, Olenik C, Just I, Aktories K (1998) The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin. Infect Immun 66:1364–9

    PubMed  CAS  Google Scholar 

  • Bartter FC, Schwartz WB (1967) The syndrome of inappropriate secretion of antidiuretic hormone. Am J Med 42:790–806

    PubMed  CAS  Google Scholar 

  • Baumgarten R, van den Pol MHJ, Wetzels JFM, van Os CH, Deen PMT (1998) Gycosylation is not essential for vasopressin dependent routing of aquaporin-2 in transfected Madin-Darby canine kidney cells. J Am Soc Nephrol 9:1553–1559

    PubMed  CAS  Google Scholar 

  • Becher A, Drenckhahn A, Pahner I, Margittai M, Jahn R (1999) The synaptophysinsynaptobrevin complexa hallmark of synaptic vesicle maturation. J Neurosci 19:1922–1931

    PubMed  CAS  Google Scholar 

  • Bendz H (1983) Kidney function in lithium treated patients. A literature survey. Acta Psychatr Scand 68:303–324

    CAS  Google Scholar 

  • Birnbaumer L, Abramowitz J, Brown AM (1990) Receptor-effector coupling by G proteins. Biochim Biophys Acta 1031:163–224

    PubMed  CAS  Google Scholar 

  • Birnbaumer M, Seibold A, Gilbert S, Ishido M, Barberis B, Antaramian A, Brabet P, Rosenthal, W (1992). Molecular cloning of the receptor for human antidiuretic hormone. Nature 357:333–335

    PubMed  CAS  Google Scholar 

  • Blanpied TA, Augustine GJ (1999) Commentary: Protein kinase A takes center stage in ATP-dependent insulin secretion. Proc Natl Acad Sci USA 96:329–331

    PubMed  CAS  Google Scholar 

  • Bloom GS, Goldstein LSB (1998) Cruising along microtubule highways: how membranes move through the secretory pathway. J Cell Biol 140:1277–1280

    PubMed  CAS  Google Scholar 

  • Bonilla-Felix M, Hamm LL, Herndon J, Vehaskari VM (1992) Response of cortical collecting ducts from remnant kidneys to arginine vasopressin. Kidney Int 41:1150–1154

    PubMed  CAS  Google Scholar 

  • Boton R, Gaviria M, Battle DC (1987) Prevalence, pathogenesis and treatment of renal dysfunction associated with chronic lithium therapy. Am J Kidney Dis 10:329–345

    PubMed  CAS  Google Scholar 

  • Bourguet J, Chevalier J, Hugon JS (1976) Alterations in membrane associated particle dirstribution during antidiuretic challenge in frog urinary epithelium. Biophys J 16:627–639

    PubMed  CAS  Google Scholar 

  • Bretscher A, Reczek D, Berryman M (1977). Ezrinia protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci 110:3011–3018

    Google Scholar 

  • Breton S, Brown D (1998) Cold-induced microtubule disruption and relocalization of membrane proteins in kidney epithelial cells. J Am Soc Nephrol 9:155–166

    PubMed  CAS  Google Scholar 

  • Breyer MD, Jacobson HR, Hebert RL (1990) Cellular mechanisms of prostaglandin E2 and vasopressin interactions in the collecting duct. Kidney Int 38:618–624.

    PubMed  CAS  Google Scholar 

  • Breyer MD (1991) Regulation of water and salt transport in collecting duct through calcium-dependent signaling mechanisms. Am J Physiol 260:F1–F11

    PubMed  CAS  Google Scholar 

  • Breyer MD, Ando Y (1994) Hormonal signaling and regulation of salt and water transport in the collecting duct. Annu Rev Physiol 56:711–739

    PubMed  CAS  Google Scholar 

  • Breyer MD, Fredin D (1996) Effect of vasopressin on intracellular Na+ concentration in cortical collecting duct. Kidney Int Suppl 57:S57–S61

    Google Scholar 

  • Breyer MD, Jacobson HR, Breyer RM (1996a) Functional and molecular aspects of renal prostaglandin receptors. J Am Soc Nephrol 7–17

    Google Scholar 

  • Breyer MD, Davies L, Jacobson HR, Breyer RM (1996b) Differential localization of prostaglandin E receptor subtypes in human kidney. Am J Physiol F912–F918

    Google Scholar 

  • Brose N, Petrenko AG, Südhof TC, Jahn R (1992) Synaptotagmin: a calcium sensor on the synaptic vesicle surface. Science 256:1021–1025

    PubMed  CAS  Google Scholar 

  • Brown D, Orci L (1983) Vasopressin stimulates the formation of coated pits in rat kidney collecting ducts. Nature 302:253–255

    PubMed  CAS  Google Scholar 

  • Brown D, Weyer P, Orci L (1988) Vasopressin stimulates endocytosis in kidney collecting duct epithelial cells. Eur J Cell Biol 46:336–340

    PubMed  CAS  Google Scholar 

  • Brown D, Sabolic I (1993) Endosomal pathways for water channel and proton pump recycling in kidney epithelial cells. J Cell Sci 17:49–59

    CAS  Google Scholar 

  • Brummermann M, Braun EJ (1995) Renal response of roosters with diabetes insipidus to infusion of arginine vasotocin. Am J Physiol 269:R57–R63

    PubMed  CAS  Google Scholar 

  • Bucci C, Parton RG, Mather IH, Stunnenberg H, Simons K, Hoflack B, Zerial M (1992) The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70:715–728

    PubMed  CAS  Google Scholar 

  • Burg M, Grantham J, Abranow M, Orloff J (1966) Preparation and study of fragments of single rabbit nephrons. Am J Physiol 210:1293–1298

    PubMed  CAS  Google Scholar 

  • Burgoyne RD, Morgan A (1998) Analysis of regulated exocytosis in adrenal chromaffin cells: insights into NSF/SNAP/SNARE function. BioEssays 20:328–335

    PubMed  CAS  Google Scholar 

  • Burnatowska-Hledin MA, Spielman WS (1987) Vasopressin increases cytosolic free calcium in LLC-PK1 cells through a V1-receptor. Am J Physiol 253:F328–F332

    PubMed  CAS  Google Scholar 

  • Byrne JH and Kandel ER (1996) Presynaptic facilitation revisited: state and time dependence. J Neurosci 16:425–435

    PubMed  CAS  Google Scholar 

  • Calamita G, Mola MG, Svelto M (1994) Presence in frog urinary bladder of proteins immunologically related to the aquaporin-CHIP. Eur J Cell Biol 64:222–228

    PubMed  CAS  Google Scholar 

  • Calhoun BC, Goldenring JR (1997) Two Rab proteins, vesicle-associated membrane protein 2 (VAMP-2) and secretory carrier membrane proteins (SCAMPs), are present on immunoisolated parietal cell tubulovesicles. Biochem J 325:559–564

    PubMed  CAS  Google Scholar 

  • Carr DW, Hausken ZE, Fraser IDC, Stofko-Hahn RE, Scott JD (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. J Biol Chem 267:13376–13382

    PubMed  CAS  Google Scholar 

  • Casanova JE, Wang X, Kumar R, Bhartur SG, Navarre J, Woodrum JE, Altschuler Y, Ray GS, Goldenring JR (1999) Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell 10:47–61.

    PubMed  CAS  Google Scholar 

  • Gasman S, Chasserot-Golaz S, Hubert P, Aunis D, Bader MF (1998) Identification of a potential effector pathway for the trimeric Go protein associated with secretory granules. Go stimulates a granule-bound phosphatidyl 4-kinase by activating RhoA in chromaffin cells. J Biol Chem 273:16913–16920

    PubMed  CAS  Google Scholar 

  • Geppert M, Bolshakov VY, Siegelbaum SA, Takei E, DeCamilli P, Hammer RE, Südhof TC (1994) The role of rab3A in neurotransmitter release. Nature. 369:493–497

    PubMed  CAS  Google Scholar 

  • Geppert M, Goda Y, Stevens CF, Südhof TC (1997) The small GTP-binding protein Rab3A regulates a late step in synaptic vesicle fusion. Nature 387:810–814

    PubMed  CAS  Google Scholar 

  • Geppert M, Südhof TC (1998) Rab3 and synaptotagmin:the yin and yang of synaptic transmission. Annu Rev Neurosci 21:75–95

    PubMed  CAS  Google Scholar 

  • Gill SR, Schroer TA, Szilak I, Steuer ER, Sheetz MP, Cleveland DW (1991) Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dhnein. J Cell Biol 115:1639–1650

    PubMed  CAS  Google Scholar 

  • Goldenring JR, Shen KR, Vaughan HD, Modlin IM (1993) Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. J Biol Chem 268:18419–18422

    PubMed  CAS  Google Scholar 

  • Goldstein JL, Anderson RGW, Brown MS (1979) Coated pits, coated vesicles, and receptor mediated endocytosis. Nature 279:679–685

    PubMed  CAS  Google Scholar 

  • Gonzalez Jr L, Scheller RH (1999) Regulation of membrane trafficking:structural insights from a rab/effector complex. Cell 96:755–758

    PubMed  CAS  Google Scholar 

  • Grantham JJ, Burg MB (1966) Effect of vasopressin and cyclic AMP on permeability of isolated collecting tubules. Am J Physiol 211:255–259

    PubMed  CAS  Google Scholar 

  • Gruenberg J, Maxfield FR (1995) Membrane transport in the endocytic pathway. Curr Opin Cell Biol 7:5563

    Google Scholar 

  • Guan Y, Zhang Y, Breyer RM, Fowler B, Davis L, Hebert RL, Breyer MD (1998) Prostaglandin E2 inhibitors renal collecting duct Na+ absorption by activating the EP1 receptor. J Clin Invest 1998 102:1–201

    Google Scholar 

  • Gustafson CE, Levine S, Katsura T, McLaughlin M, Aleixo MD, Tamarappoo BK, Verkman AS, Brown D (1998) Vasopressin-regulated trafficking of a green fluorescent protein-aquaporin2 chimera in LLC-PK1 cells. Histochem Cell Biol 110:377–386

    PubMed  CAS  Google Scholar 

  • Hackenthal E, Paul M, Ganten D, Taugner R (1990) Morphology, physiology, and molecular biology of renin secretion. Physiol Rev 70:1076–1116

    Google Scholar 

  • Hadley ME (1996) Endocrinology. Prentice Hall International, Inc. NJ, USA

    Google Scholar 

  • Hall A (1998) Rho GTPases and the actin cytoskeleton. Science 279:509–514

    PubMed  CAS  Google Scholar 

  • Hamm-Alvarez SF, Sheetz MP (1998) Microtubule-dependent vesicle transport:modulation of channel and transporter activity in liver and kidney. Phys Rev 78:1109–1129

    CAS  Google Scholar 

  • Hammond TG, Morre DJ, Harris Jr HW, Zeidel ML (1993) Isolation of highly purified, functional endosomes from toad urinary bladder. Biochem J 295:471–476

    PubMed  CAS  Google Scholar 

  • Handler JS (1988) Antidiuretic hormone moves membranes. Am J Physiol 255:F375–F382

    PubMed  CAS  Google Scholar 

  • Harmanci MC, Stern P, Kachadorian WA, Valtin H, DiScala VA (1978) Antidiuretic hormone-induced intramembraneous alterations in mammlian collecting duct. Am J Physiol 235:F440–F443

    CAS  Google Scholar 

  • Harris Jr HW, Strange K, Zeidel ML (1991) Current understanding of the cellular biology and molecular structure of the antidiuretic hormone-stimulated water transport pathway. J Clin Invest 88:1–8

    PubMed  CAS  Google Scholar 

  • Harris HW Jr, Zeidel ML, Jo I, Hammond TG (1994) Characterization of purified endosomes containing the antidiuretic hormone-sensitive water channel from rat renal papilla. J Biol Chem 269:11993–2000

    PubMed  CAS  Google Scholar 

  • Hasegawa H, Ma T, Skach W, Matthay MA, Verkman AS (1994) Molecular cloning of a mercurial insensitive water channel expressed in selected water-transporting tissues. J Biol Chem 269:5497–5500

    PubMed  CAS  Google Scholar 

  • Hay JC, Scheller RH (1997) SNAREs and NSF in targeted membrane fusion. Curr Opin Cell Biol 9:505–512

    PubMed  CAS  Google Scholar 

  • Hays RM, Leaf A (1962) Studies on the movement of water through the isolated toad bladder and its modification by vasopressin. J Gen Physiol 45:905–919

    PubMed  CAS  Google Scholar 

  • Hays RM, Franki N, Simon H, Gao Y (1994) Antidiuretic hormone and exocytosis:lessons from neurosecretion. Am J Physiol 267:C1507–C1524

    PubMed  CAS  Google Scholar 

  • Hays R.M. (1996) Cellular and molecular events in the action of antidiuretic hormone. Kindney Int 49, 1700–1705

    CAS  Google Scholar 

  • Hebert RL, Jacobson HR, Breyer MD (1990) PGE2 inhibits AVP-induced water flow in cortical collecting ducts by protein kinase C activation. Am J Physiol 259:F318–325

    PubMed  CAS  Google Scholar 

  • Hebert RL, Jacobson HR, Breyer MD (1991) Prostaglanding E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium. J Clin Invest 87:1992–1998

    PubMed  CAS  Google Scholar 

  • Hebert RL, Jacobson HR, Fredin D, Breyer MD (1993) Evidence that separate PGE2 receptors modulate water and sodium transport in rabbit cortical collecting duct. Am J Physiol 265:F643–650

    PubMed  CAS  Google Scholar 

  • Helms JB (1995) Role of heterotrimeric GTP binding proteins in vesicular protein transport:indications for both classical and alternative G protein cycles. FEBS Lett 369:84–88

    PubMed  CAS  Google Scholar 

  • Helms JB, Helms-Brons D, Brugger B, Gkantiragas I, Eberle H, Nickel W, Nurnberg B, Gerdes HH, Wieland FT (1998) A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem 273:15203–15208

    PubMed  CAS  Google Scholar 

  • Holleran EA, Karki S, Holzbaur ELF (1998) The role of dynactin complex in intracellular motility. Int Rev Cytol 182:69–109

    PubMed  CAS  Google Scholar 

  • Höhler T, Teuber G, Warnitschke R, Meyer zum Büschenfeld KH (1994) Indomethacin treatment in amphotericin B induced neprogenic diabetes insipidus. Clin Invest 72:769–771

    Google Scholar 

  • Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (1997a) Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem 272:8057–8064

    PubMed  CAS  Google Scholar 

  • Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS (1997b) D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci USA 94:11184–1118

    PubMed  CAS  Google Scholar 

  • Inoue T, Nielsen S, Mandon B, Terris J, Kishore BK, Knepper M (1998) SNAP-23 in rat kidney:colocalization with aquaporin-2 in collecting duct vesicles. Am J Physiol 275:F752–F760

    PubMed  CAS  Google Scholar 

  • Ishibashi K, Sasaki S, Fushimi K, Uchida S, Kuwahara M, Saito H, Furukawa T, Nakajima K, Yamaguchi Y, Gojobori T, Marumo F (1994) Molecular cloning and expression of a member of the aquaporin family with peremeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells. Proc Natl Acad Sci USA 91:6269–6273

    PubMed  CAS  Google Scholar 

  • Jahn R, Südhof TC (1994) Synaptic vesicles and exocytosis. Annu Rev Neurosci 17:219–46

    PubMed  CAS  Google Scholar 

  • Jamora C, Takizawa PA, Zaarour RF, Denesvre C, Faulkner J, Malhotra V (1997) Regulation of Golgi structure through heterotrimeric G proteins. Cell 91:617–626

    PubMed  CAS  Google Scholar 

  • Jena BP, Schneider SW, Geibel JP, Webster P, Oberleithner H, Sritharan KC (1997) Gi regulation of secretory vesicle swelling examined by atomic force microscopy. Proc Natl Acad Sci USA 94:13317–13322

    PubMed  CAS  Google Scholar 

  • Jo I, Harris HW, Amendt-Raduege AM, Majewski RR, Hammond TG (1995) Rat kidney papilla contains abundant synaptobrevin protein that participates in the fusion of antidiuretic hormone-regulated water channel-containing endosomes in vitro. Proc Natl Acad Sci USA 92:1876–1880

    PubMed  CAS  Google Scholar 

  • Jung JS, Bhat RV, Preston GM, Guggino WB, Baraban JM, Agre P (1994) Molecular characterization of an aquaporin cDNA from brain:candidate osmoreceptor and regulator of water balance. Proc Natl Acad Sci USA 91:13052–13056

    PubMed  CAS  Google Scholar 

  • Just I, Selzer J, Wilm M, von Eichel-Streiber C, Mann M, Aktories K (1995) Glucosylation of Rho proteins by Clostridium difficile toxin B. Nature 375:500–503

    PubMed  CAS  Google Scholar 

  • Kachadorian WA, Sariban-Sohraby S, Spring KR (1985) Regulation of water permeability in toad urinary bladder at two barriers. Am J Physiol 248:F260–F265

    PubMed  CAS  Google Scholar 

  • Kamsteeg EJ, Wormhoudt TA, Rijss JP, van Os CH, Deen PM (1999). An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus. EMBO J 18:2394–2400

    PubMed  CAS  Google Scholar 

  • Karki S, Holzbaur ELF (1999) Cytoplasmic dynein and dynactin in cell division and intracellular transport. Curr Opin Cell Biol 11:45–53

    PubMed  CAS  Google Scholar 

  • Kasner M, Grosse J, Krebs M, Kaczmarczyk G (1995) Methohexital impairs osmoregulation:studies in concsious and anesthetized volume-expanded dogs. Anesthesiology 82:1396–1405

    PubMed  CAS  Google Scholar 

  • Kato M, Sasaki T, Ohya T, Nakanishi H, Nishioka H, Imamura M, Takai Y (1996) Physical and functional interaction of rabphilin-3A with alpha-actinin. J Biol Chem 271:31775–31778

    PubMed  CAS  Google Scholar 

  • Katsura T, Verbavatz JM, Farinas J, Ma T, Ausiello DA, Verkman AS, Brown D (1995) Constitutive and regulated membrane expression of aquaporin1 and aquaporin2 water channels in stably transfected LLC-PK1 epithelial cells. Proc Natl Acad Sci USA 92:7212–7216

    PubMed  CAS  Google Scholar 

  • Katsura T, Ausiello DA, Brown D (1996) Direct demonstration of aquaporin-2 water channel recycling in stably transfected LLC-PK1 epithelial cells. Am J Physiol 270:F548–F553

    PubMed  CAS  Google Scholar 

  • Katsura T, Gustafson CE, Ausiello DA, Brown D (1997) Protein kinase A phosphorylation is involved in regulated exocytosis of aquaporin-2 in transfected LLC-PK1 cells. Am J Physiol 272:F816–F822

    CAS  Google Scholar 

  • Kehlenbach RH, Matthey J, Huttner WB (1994) Xl alpha s is a new type of G protein. Nature 372:804–809. (1995) 375:253

    PubMed  CAS  Google Scholar 

  • Klussmann E, Maric K, Krause E, Eichhorst J, Beziat P, Rosenthal W (1998) Molecular mechanisms of exocytosis in epithelial cells of the kidney. Congress of Molecular Medicine. Berlin, Germany, 1998. J Mol Med 76:B58 (abstract)

    Google Scholar 

  • Klussmann E, Maric K, Wiesner B, Beyermann M, Rosenthal W (1999) Protein kinase A anchoring proteins are required for vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem 274:4934–4938

    PubMed  CAS  Google Scholar 

  • Knepper MA, Wade JB, Terris J, Ecelbarger CA, Marples D, Mandon B, Chou CL, Kishore BK, Nielsen S (1996) Renal aquaporins. Kidney Int 49:1712–1717

    PubMed  CAS  Google Scholar 

  • Koeford-Johnson V, Ussing HH (1953) The contributions of diffusion and flow to the passage of D2O through living membranes. Acta Physiol Scand 28:60–76.

    Google Scholar 

  • Kohan DE, Padilla E, Hughes AK (1993) Endothelin B receptor mediates ET-1 effects on cAMP and PGE2 accumulation in rat IMCD. Am J Physiol 265:F670–F676.

    PubMed  CAS  Google Scholar 

  • Kohan DE (1998) Endothelin modulation of renal sodium and water transport. In: Pollock DM, Highsmith RF (eds) Endothelin receptors and signaling mechanisms. Springer-Verlag and R.G. Landes Company, pp 101–113.

    Google Scholar 

  • Konrad RJ, Young RA, Record RD, Smith RM, Butkerait P, Manning D, Jarret L, Wolf BA (1995) The heterotrimeric G protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis. J Biol Chem 270:12869–12876.

    PubMed  CAS  Google Scholar 

  • Kowluru A, Seavey SE, Rhodes CJ, Metz SA (1996) A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells. Biochem J 313:97–107.

    PubMed  CAS  Google Scholar 

  • Kumagami H, Loewenheim H, Beitz E, Wild K, Schwartz H, Yamashita K, Schultz J, Paysan J, Zenner HP, Ruppersberg JP (1998) The effect of antidiuretic hormone on the endolymphatic sac of the inner ear. Pflugers Arch 436:970–975.

    PubMed  CAS  Google Scholar 

  • Kurtz A (1989) Cellular control of renin secretion. Rev Physiol Biochem Pharmacol 113:1–40.

    PubMed  CAS  Google Scholar 

  • Kuwahara M, Fushimi K, Terada Y, Bai L, Marumo F, Sasaki S (1995) cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. J Biol Chem 270:10384–10387

    PubMed  CAS  Google Scholar 

  • Kwon TH, Frokiaer J, Knepper MA, Nielsen S (1998) Reduced AQP1,-2 and-3 levels in kidneys of rats with CRF induced by surgical reduction in renal mass. Am J Physiol 275:F724–F741

    PubMed  CAS  Google Scholar 

  • Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB (1996) The 2.0 A crystal structure of a heterotrimeric G protein. Nature 379:311–319

    PubMed  CAS  Google Scholar 

  • Lande MB, Jo I, Zeidel ML, Somers M, Harris HW (1996) Phosphorylation of aquaporin-2 does not alter the membrane water permeability of papillary water channel-containing vesicles. J Biol Chem 271:5552–5557

    PubMed  CAS  Google Scholar 

  • Lester LB, Langeberg LK, Scott JD (1997) Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc Natl Acad Sci USA 94:14942–14947

    PubMed  CAS  Google Scholar 

  • Lester LB, Scott JD (1997) Anchoring and scaffold proteins for kinases and phosphatases. Recent Prog Horm Res 52:409–430

    PubMed  CAS  Google Scholar 

  • Li C, Takei K, Geppert M, Daniell L, Stenius K, Chapman ER, Jahn R, DeCamilli P, Südhof TC (1994) Synaptic targeting of rabphilin-3A, a synaptic vesicle Ca2+/phospholipid-binding protein, depends on rab3A/3C. Neuron 13:885–98

    PubMed  CAS  Google Scholar 

  • Liebenhoff U, Rosenthal W (1995) Identification of Rab3, Rab5a-and synaptobrevin II-like proteins in a preparation of rat kidney vesicles containing the vasopressin-regulated water channel. FEBS Lett 365:209–213

    PubMed  CAS  Google Scholar 

  • Linial M (1997) SNARE proteins—why so many, why so few? J Neurochem 69:1781–1792

    PubMed  CAS  Google Scholar 

  • Lledo PM, Vernier P, Vincent JD, Mason WT, Zorec R (1993) Inhibition of Rab3B expression attenuates Ca(2+)-dependent exocytosis in rat anterior pituitary cells. Nature 364:540–544

    PubMed  CAS  Google Scholar 

  • Ludger J, Galli T (1998) Exocytosis:SNAREs drum up. Eur J Neurosci 10:415–422

    PubMed  Google Scholar 

  • Lutcke A, Jansson S, Parton RG, Chavrier P, Valencia A, Huber LA, Lehtonen E, Zerial M (1993) Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol 121:553–564

    PubMed  CAS  Google Scholar 

  • Luzius H, Jans DA, Grünbaum EG, Moritz A, Rascher W, Fahrenholz F (1992) A low affinity vasopressin V2-receptor in inherited nephrogenic diabetes insipidus. J Recept Res 12:351–368

    PubMed  CAS  Google Scholar 

  • Ma T, Frigeri A, Skach W, Verkman AS (1993a) Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Biochem Biophys Res Comm 197:654–659

    PubMed  CAS  Google Scholar 

  • Ma T, Frigeri A, Tsai ST, Verbavatz JM, Verkman AS (1993b) Localization and functional analysis of CHIP28k water channels in stably transfected chinese hamster ovary cells. J Biol Chem 268:22756–22764

    PubMed  CAS  Google Scholar 

  • Ma T, Yang B, Gillespie A, Carlson EJ, Verkman AS (1998) Severly impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem 273:4296–4299

    PubMed  CAS  Google Scholar 

  • Maeda Y, Han JS, Gibson CC, Knepper MA (1993) Vasopressin and oxytocin receptors coupled to Ca2+ mobilization in rat inner medullary collecting duct. Am J Physiol 265:F15–F25

    PubMed  CAS  Google Scholar 

  • Mandelkow E, Hoenger A (1999) Structures of kinesin and kinesin-microtubule interactions. Curr Opin Cell Biol 11:34–44

    PubMed  CAS  Google Scholar 

  • Mandon B, Chou C-L, Nielsen S, Knepper M (1996) Syntaxin-4 is localized to the apical plasma membrane of rat renal collecting duct cells:possible role in aquaporin-2 trafficking. J Clin Invest 98:906–913

    PubMed  CAS  Google Scholar 

  • Mangeat P, Roy C, Martin M (1999) ERM proteins in cell adhesion and membrane dynamics. Trends Cell Biol 9:187–192

    PubMed  CAS  Google Scholar 

  • Maric K, Oksche A, Rosenthal W (1998) Aquaporin-2 expression in primary cultured rat inner medullary collecting duct cells. Am J Physiol 275:F796–801

    PubMed  CAS  Google Scholar 

  • Marples D, Christensen S, Christensen EI, Ottosen PD, Nielsen S (1995) Lithium-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla. J Clin Invest 95:1838–1845

    PubMed  CAS  Google Scholar 

  • Marples D, Frokiaer J, Dorup J, Knepper MA, Nielsen S (1996) Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. J Clin Invest 97:1960–1968

    PubMed  CAS  Google Scholar 

  • Marples D, Schroer TA, Ahrens N, Taylor A, Knepper MA, Nielsen S (1998) Dynein and dynactin colocalize with AQP2 water channels in intracellular vesicles from kidney collecting duct. Am J Physiol 274:F384–F394

    PubMed  CAS  Google Scholar 

  • Marples D, Froekiaer J, Nielsen S (1999) Long-term regulation of aquaporins in the kidney. Am J Physiol 276:F331–339

    PubMed  CAS  Google Scholar 

  • Martinez O, Goud B (1998) Rab proteins. Biochim Biophys Acta 1404:101–112

    PubMed  CAS  Google Scholar 

  • McMahon HT, Ushkaryov YA, Edelmann L, Link E, Binz T, Niemann H, Jahn R, Südhoff TC (1993) Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein. Nature 364:346–349

    PubMed  CAS  Google Scholar 

  • McLauchlan H, Newell J, Morrice N, Osborne A, West M, Smythe E (1998) A novel role for Rab5-GDI in ligand sequestration into clathrin-coated pits. Curr Biol 8:34–45

    PubMed  CAS  Google Scholar 

  • Meads T, Schroer TA (1995) Polarity and nucleation of microtubules in polarized epithelial cells. Cell Motil Cytoskeleton 32:273–288

    PubMed  CAS  Google Scholar 

  • Migas I, Backer A, Meyer-Lehnert H, Michel H, Wulfhekel U, Kramer HJ (1993) Characteristics of endothelin receptors and intracellular signalling in porcine inner medullary collecting duct cells. Am J Hypertens 6:611–618

    PubMed  CAS  Google Scholar 

  • Mills IG, Jones AT, Clague MJ (1999) Regulation of endosome fusion. Mol Membr Biol 16:73–79

    PubMed  CAS  Google Scholar 

  • Montmayeur J-P, Borrelli E (1994) Targeting of Gαi2 to the Golgi by alternative spliced carboxyl-terminal region. Science 263:95–98

    PubMed  CAS  Google Scholar 

  • Mohrmann K, van der Sluijs P (1999) Regulation of membrane transport through the endocytic pathway by rabGTPases. Mol Membr Biol 16:81–87

    PubMed  CAS  Google Scholar 

  • Mork A, Geisler A (1995) A comparative study on the effects of tetracyclines and lithium on the cyclic-AMP and second messenger system in the rat brain. Prog Neuro Psycho Biol Psych 19:157–169

    CAS  Google Scholar 

  • Moullier P, Friedlander G, Calise D, Ronco P, Perricaudet M, Ferry N (1994) Adenoviral-mediated gene transfer to renal tubular cells in vivo. Kidney Int 45:1220–1225

    PubMed  CAS  Google Scholar 

  • Mulders SM, Bichet DG, Rijss JP, Kamsteeg EJ, Arthus MF, Lonergan M, Fujiwara M, Morgan K, Leijendekker R, van der Sluijs P, van Os CH, Deen PM (1998) An aquaporin-2 water channel mutant which causes autosomal dominant nephrogenic diabetes insipidus is retained in the Golgi complex. J Clin Invest 102:57–66

    PubMed  CAS  Google Scholar 

  • Niederberger M, Martin PY, Gines P (1995) Normalization of nitric oxide production corrects arterial vasodilatation and hyperdynamic circulation in cirrhotic rats. Gastroenterology 109:1624–1630

    PubMed  CAS  Google Scholar 

  • Nielsen S, Muller J, Knepper MA (1993a) Vasopressin-and cAMP-induced changes in ultrastructure of isolated perfused inner medullary collecting ducts. Am J Physiol 265:F225–238

    PubMed  CAS  Google Scholar 

  • Nielsen S, DiGiovanni SR, Christensen EI, Knepper MA, Harris HW (1993b) Cellular and subcellular immunolocalization of vasopressin-regulated water channel in rat kidney. Proc Natl Acad Sci USA 90:11663–11667

    PubMed  CAS  Google Scholar 

  • Nielsen S, Marples D, Birn H, Mohtashami M, Dalby NO, Trimble W, Knepper MA (1995a) Expression of Vamp2-like protein in kidney collecting duct intracellular vesicles. J Clin Invest 96:1834–1844

    PubMed  CAS  Google Scholar 

  • Nielsen S, Chou C-L, Marples D, Christensen EI, Kishore BK, Knepper MA (1995b) Vasopressin increases water permeability of kidney collecting duct by inducing translocation of aquaporin-CD water channels to plasma membrane. Proc Natl Acad Sci USA 92:1013–1017

    PubMed  CAS  Google Scholar 

  • Nielsen S, Terris J, Andersen D, Ecelbarger C, Frokiaer J, Jonassen T, Marples D, Knepper MA, Petersen JS (1997) Congestive heart failiure in rats associated with increased expression and targetting of aquaporin-2 water channel in collecting duct. Proc Natl Acad Sci USA 94:5450–5455

    PubMed  CAS  Google Scholar 

  • Nonoguchi H, Sands JM, Knepper MA (1988) Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct. J Clin Invest 82:1383–1390

    PubMed  CAS  Google Scholar 

  • Nonoguchi H, Sands JM, Knepper MA (1989) ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney. Am J Physiol 256:F179–F186

    PubMed  CAS  Google Scholar 

  • Novick P, Zerial M (1997) The diversity of Rab proteins in vesicle transport. Curr Opin Cell Biol 9:496–504

    PubMed  CAS  Google Scholar 

  • Nürnberg B, Ahnert-Hilger G (1996) Potential roles of heterotrimeric G proteins of the endomembrane system. FEBS Lett 389:61–65

    PubMed  Google Scholar 

  • Offermann S, Simon M (1996) Organization of transmembrane signalling by heterotrimeric G proteins. In:Cancer Surveys 27:Cell Signalling. Imperial Cancer Research Fund

    Google Scholar 

  • Ohara M, Martin PY, Xu DL, StJohn J, Pattison TA, Kim JK, Schrier RW (1998) Upregulation of aquaporin 2 water channel expression in pregnent rats. J Clin Invest 101:1076–1083

    PubMed  CAS  Google Scholar 

  • Oksche A, Rosenthal W (1998) The molecular basis of nephrogenic diabetes insipidus. J Mol Med 76:326–337

    PubMed  CAS  Google Scholar 

  • Olefsky JM (1999) Insulin-stimulated glucose transport minireview series. J Biol Chem 274:1863

    PubMed  CAS  Google Scholar 

  • Osborne SL, Herreros J, Bastiaens PIH, Schiavo G (1999) Calcium-dependent oligomerization of synaptotagmins I and II. J Biol Chem 274:59–66

    PubMed  CAS  Google Scholar 

  • Otto H, Hanson PI, Jahn R (1997) Assembly and disassembly of a ternary complex of synaptobrevin, syntaxin, and SNAP-25 in the membrane of synaptic vesicles. Proc Natl Acad Sci USA 94:6197–6201

    PubMed  CAS  Google Scholar 

  • Palmer LG, Lorenzen M (1983) Antidiuretic hormone-dependent membrane capacitance and water permeability in the toad urinary bladder. Am J Physiol 244:F195–F204

    PubMed  CAS  Google Scholar 

  • Pawson T, Scott JD (1997) Signalling through scaffolding, anchoring and adaptor proteins. Science 278:2075–2080

    PubMed  CAS  Google Scholar 

  • Pearl M, Taylor A (1983) Actin filaments and vasopressin-stimulated water flow in toad urinary bladder. Am J Physiol 245:C28–C39

    PubMed  CAS  Google Scholar 

  • Peters C, Mayer A (1998) Ca2+/calmodulin signals the completions of docking and triggers a late step of vacuole fusion. Nature 396:575–580

    PubMed  CAS  Google Scholar 

  • Pfeffer SR (1999) Transport-vesicle targeting:tethers before SNAREs. Nature Cell Biol 1:E17–E22

    PubMed  CAS  Google Scholar 

  • Phillips ME, Taylor A (1989) Effect of nocodazole on the water permeability response to vasopressin in rabbit collecting tubules in vitro. J Physiol 411:529–544

    PubMed  CAS  Google Scholar 

  • Phillips ME, Taylor A (1992) Effect of colcemid on the water permeability response to vasopressin in isolated perfused rabbit collecting tubules. J Physiol 456:591–608

    PubMed  CAS  Google Scholar 

  • Pimplikar SW, Simons K (1994) Activators of protein kinase A stimulate apical but not basolateral transport in epithelial madin-darby canine kidney cells. J Biol Chem 269:19054–19059

    PubMed  CAS  Google Scholar 

  • Pinxteren JA, O’Sullivan AJ, Tatham PER, Gomberts BD (1998) Regulation of exocytosis from rat peritoneal mast cells by G protein βγ-subunits. EMBO J 17:6210–6218

    PubMed  CAS  Google Scholar 

  • Preston GM, Agre P (1991) Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons:Member of an ancient channel family. Proc Natl Acad Sci USA 88:11110–11114

    PubMed  CAS  Google Scholar 

  • Preston GM, Carroll TP, Guggino WB, Agre P (1992) Appearence of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science 256:385–387

    PubMed  CAS  Google Scholar 

  • Preston GM, Smith BL, Christensen EI, Agre P (1994) Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 265:1585–1587

    PubMed  CAS  Google Scholar 

  • Rai T, Uchida S, Marumo F, Saski S (1997) Cloning of rat and mouse aquaporin-2 gene promoters and identification of a negative cis-regulatory element. Am J Physiol 273:F264–F273

    PubMed  CAS  Google Scholar 

  • Ravichandra V, Chawla A, Roche PA (1996) Identification of a novel syntaxin-and synaptobrevin/Vamp-binding protiin, SNAP-23, expressed in non-neuronal cells. J Biol Chem 271:13300–13303

    Google Scholar 

  • Rea S, Martin LB, McIntosh S, Macaulay SL, Ramsdale T, Baldini G, James DE (1998) Syndet, an adipocyte target SNARE involved in the insulin-induced translocation of GLUT4 to the cell surface. J Biol Chem 273:18784–18792

    PubMed  CAS  Google Scholar 

  • Ren M, Xu G, Zeng J, de Lemos-Chiarandini C, Adesnik M, Sabatini DD (1998) Hydrolysis of GTP on rabll is required for direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes. Proc Natl Acad Sci USA 95:6187–6192

    PubMed  CAS  Google Scholar 

  • Riezman H, Woodman PG, van Meer G, Marsh M (1997) Molecular mechanism of endocytosis. Cell 91:731–738

    PubMed  CAS  Google Scholar 

  • Robertson GL (1995) Diabetes insipidus. Endocrinol Metab Clin North Am. 24:549–72

    PubMed  CAS  Google Scholar 

  • Robinson LJ, Martin TFJ (1998) Docking and fusion in neurosecretion. Curr Opin Cell Biol 10:483–492

    PubMed  CAS  Google Scholar 

  • Rosenthal W, Seibold A, Antaramian A, Lonergan M, Arthus M-F, Hendy G, Birnbaumer M, Bichet D (1992) Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus. Nature 359:233–235

    PubMed  CAS  Google Scholar 

  • Rosenthal W, Seibold A, Bichet DG, Birnbaumer M (1996) Diabetes insipidus. In: Encyclopedia of Molecular Biology and Molecular Medicine 2:19–28

    Google Scholar 

  • Rosenthal W, Oksche A, Bichet DG (1998) Two genes-one disease:the molecular basis of congenital nephrogenic diabetes insipidus. Adv Mol Cell Endocrinol 2:143–167

    CAS  Google Scholar 

  • Rothman JE (1994) Mechanisms of intracellular protein transport. Nature 372:55–63

    PubMed  CAS  Google Scholar 

  • Roychowdhury S, Rasenick MM (1997) G protein beta1gamma2 subunits promote microtubule assembly. J Biol Chem 272:31576–31581

    PubMed  CAS  Google Scholar 

  • Roychowdhury S, Panda D, Wilson L, Rasenick MM (1999) G protein α subunits activate tubulin GTPase and modulate microtubule polymerization dynamics. J Biol Chem 274:13485–13490

    PubMed  CAS  Google Scholar 

  • Rubin CS (1994) A kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim Biophys Acta 1224:467–479

    PubMed  Google Scholar 

  • Ruhfus B, Bauernschmitt HG, Kinne RKH (1998) Properties of a polarized primary culture from rat renal inner medullary collecting duct (IMCD) cells. In Vitro Cell Dev Biol—Animal 34:227–231

    CAS  Google Scholar 

  • Rutishauser J, Kopp P (1999) Aquaporin-2 water channel mutations and nephrogenic diabetes insipidus:new variations on a theme. Eur J Endocrinol 140:137–139

    PubMed  CAS  Google Scholar 

  • Rybin V, Ullrich O, Rubino M, Alexandrov K, Simon I, Seabra MC, Goody R, Zerial M (1996) GTPase activity of Rab5 acts as a timer for endocytic membrane fusion. Nature 383:266–269

    PubMed  CAS  Google Scholar 

  • Saavedra JM (1992) Brain and pituitary angiotensin. Endocr Rev 13:329–380

    PubMed  CAS  Google Scholar 

  • Sabolic I, Wuarin F, Shi LB, Verkman AS, Ausiello DA, Gluck S, Brown D (1992) Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping. ATPase. J Cell Biol 119:111–22

    CAS  Google Scholar 

  • Sabolic I, Katsura T, Verbavatz J-M, Brown D (1995) The AQP2 water channel: effect of vasopressin treatment, microtubule disruption, and distribution in neonatal rats. J Mem Biol 143:165–175

    CAS  Google Scholar 

  • Sakairi Y, Jacobson HR, Noland TD, Breyer MD (1995) Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct. Am J Physiol 269:F257–F265

    PubMed  CAS  Google Scholar 

  • Sands JM, Naruse M, Baum M, Jo I, Hebert SC, Brown EM, Harris HW (1997) Apical extracellular calcium/polyvalent cation-sensing receptor regulates vasopressinelicited water permeability in rat kidney inner medullary collecting duct. J Clin Invest 99:1399–1405

    PubMed  CAS  Google Scholar 

  • Sasaki S, Fushimi K, Saito H, Saito F, Uchida S, Ishibashi K, Kuwahara M, Ikeuchi T, Inui K, Nakajama K, Watanabe TX, Marumo F. (1994) Cloning, characterization, and chromosomal mapping of human aquaporin of collecting duct. J Clin Invest 93:1250–1256

    PubMed  CAS  Google Scholar 

  • Sasaki S, Ishibashi K, Marumo F (1998) Aquaporin-2 and-3:representatives of two subgroups of the aquaporin family colocalized in the kidney collecting duct. Annu Rev Physiol 60:199–220

    PubMed  CAS  Google Scholar 

  • Schimmöller F, Simon I, Pfeffer SR (1998) Rab GTPases, directors of vesicle docking. J Biol Chem 273:22161–22164

    PubMed  Google Scholar 

  • Schliefer K, Rockstroh JK, Spengler U, Sauerbruch T (1997) Nephrogenic diabetes insipidus in a patient taking cidofovir. Lancet 350:413–414;350:1558

    PubMed  CAS  Google Scholar 

  • Schmale H, Richter D (1984) Single base deletion is the cause of diabetes insipidus in Brattleboro rats. Nature 308:705–709

    PubMed  CAS  Google Scholar 

  • Schmale H, Bahnsen U, Richter D (1993) Structure and expression of the vasopressin precursor gene in central diabetes insipidus. Ann NY Acad Sci 689:74–82

    PubMed  CAS  Google Scholar 

  • Schmid SL (1997) Clathrin-coated vesicle formation and protein sorting:an integrated process. Annu Rev Biochem 66:511–548

    PubMed  CAS  Google Scholar 

  • Schmidt G, Aktories K (1998) Bacterial cytotoxins target Rho GTPases. Naturwissenschaften 85:253–261

    PubMed  CAS  Google Scholar 

  • Schrier RW, Fassett RG, Ohara M, Martin PY (1998) Vasopressin release, water channels, and vasopressin antagonism in cardiac failiure, cirrhosis and pregnancy. Proc Assoc Am Physicians 110:407–411

    PubMed  CAS  Google Scholar 

  • Schroer TA, Sheetz MP (1991) Two activators of microtubule-based vesicle tranport. J Cell Biol 115:1309–1318

    PubMed  CAS  Google Scholar 

  • Schülein R, Lorenz D, Oksche A, Wiesner B, Hermosilla R, Ebert J, Rosenthal W (1998) Polarized cell surface expression of the green fluorescent-protein vasopressin V2 receptor in Madin Darby canine kidney cells. FEBS Lett 441:170–176

    PubMed  Google Scholar 

  • Scott JD (1997) Dissection of protein kinase and phosphatase targeting interactions. Soc Gen Physiol Ser 52:227–239

    PubMed  CAS  Google Scholar 

  • Seasholtz TM, Majumdar M, Brown JH (1999) Rho as mediator of G protein-coupled receptor signalling. Mol Pharmacol 55:949–956

    PubMed  CAS  Google Scholar 

  • Sever S, Mulberg AB, Schmid SL (1999) Impairment of dynamin’s GAP domain stimulates receptor-mediated endocytosis. Nature 398:481–486

    PubMed  CAS  Google Scholar 

  • Shirataki H, Kaibuchi K, Sakoda T, Kishida S, Yamaguchi T, Wada K, Miyazaki M, Takai Y (1993) Rabphilin-3A, a putative target protein for smg p25A/rab3A p 25 small GTP-binding protein related to synaptotagmin. Mol Cell Biol 13:2061–2068

    PubMed  CAS  Google Scholar 

  • Simon H, Gao Y, Franki N, Hays RM (1993) Vasopressin depolymerizes apical Factin in rat inner medullary collecting duct. Am J Physiol 265:C757–C762

    PubMed  CAS  Google Scholar 

  • Slembrouck D, Annaert WG, Wang JM, Potter WP (1999) Rab3 is present on endosomes from bovine chromaffin cells in primary culture. J Cell Sci 112:641–649

    PubMed  CAS  Google Scholar 

  • Snyder HM, Fredin DM, Breyer MD (1991) Muscarinergic receptor activation inhibits AVP-induced water flow in rabbit cortical collecting ducts. Am J Physiol 260:F929–F936

    PubMed  CAS  Google Scholar 

  • Snyder HM, Noland TD, Breyer MD (1992) cAMP-dependent protein kinase mediates hydrosmotic effect of vasopressin in collecting duct. Am J Physiol 263:C147–C153

    PubMed  CAS  Google Scholar 

  • Sonnenberg H (1990) Mechanisms of release and renal action of atrial natriuretic factor. Acta Physiol Scand Supl 591:80–87

    CAS  Google Scholar 

  • Stahl B, Chou JH, Li C, Südhof TC, Jahn R (1995) Rab3 reversibly recruits rabphilin to synaptic vesicles by a mechanism analogous to raf recruitment by ras. EMBO J 15:1799–1809

    Google Scholar 

  • Star RA, Nonoguchi H, Balaban R, Knepper MA (1988) Calcium and cyclic adenosine monophosphate as second messengers for vasopressin in the rat inner medullary collecting duct. J Clin Invest 81:1879–1888

    PubMed  CAS  Google Scholar 

  • Stetson DL, Lewis SA, Alles W, Wade JB (1982) Evaluation by capacitance measurements of antidiuretic hormone induced membrane area changes in toad bladder. Biochim Biophys Acta 689:267–274

    PubMed  CAS  Google Scholar 

  • Stow JL, de Almeida JB, Narula N, Holtzman EJ, Ercolani L, Ausiello DA (1991) A heterotrimeric G protein, G alpha i-3, on Golgi membranes regulates the secretion of a heparan sulfate proteoglycan in LLC-PK1 epithelial cells. J Cell Biol 114:1113–1124

    PubMed  CAS  Google Scholar 

  • Stowell MHB, Marks B, Wigge P, McMahon HAT (1999) Nucleotide-dependent conformational changes in dynamin:evidence for a mechanochemical molecular spring. Nature Cell Biol 1:27–32.

    PubMed  CAS  Google Scholar 

  • Strange K, Willingham MC, Handler JS, Harris, Jr, HW (1988) Apical membrane endocytosis via coated pits is stimulated by removal of antidiuretic hormone from isolated, perfused rabbit cortical collecting tubule. J Membr Biol 103:17–28.

    PubMed  CAS  Google Scholar 

  • Südhof T (1995) The synaptic vesicle cucle:a cascade of protein-protein interactions. Nature 375:645–653

    PubMed  Google Scholar 

  • Sutton RB, Fassauer D, Jahn R, Brunger AT (1998) Crystal structure of a SNARE complex involved in synaptic exocytosis at a 2.4 A resolution. Nature 395:347–353

    PubMed  CAS  Google Scholar 

  • Sweet D (1999) The SAC, EEA1, rab5 and endosome fusion. Trends Cell Biol 9:149

    PubMed  Google Scholar 

  • Takacs-Jarrett M, Sweeney WE, Avner ED, Cotton CU (1998) Morphological and functional characterization of a conditionally immortalized collecting tubule cell line. Am J Physiol 275:F802–F811

    PubMed  CAS  Google Scholar 

  • Takahashi N, Kadowaki T, Yazaki Y, Ellis-Davies GCR, Miyashita Y, Kasai H (1999) Post-priming actions of ATP on Ca2+-dependent exocytosis in pancreatic beta cells. Proc Natl Acad Sci USA 96:760–765

    PubMed  CAS  Google Scholar 

  • Takei K, Slepnev VI, Haucke V, De Camilli P (1999) Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis. Nature Cell Biol 1:33–39

    PubMed  CAS  Google Scholar 

  • Tamarappoo BK, Verkman AS (1998) Defective aquaporin-2 trafficking in nephrogenic diabetes insipidus and correction by chemical chaperones. J Clin Invest 101:2257–2267

    PubMed  CAS  Google Scholar 

  • Tasken K, Skalhegg BS, Tasken KA, Solberg R, Knutsen HK, Levy FO, Sandberg M, Orstavik S, Larsen T, Johansen AK, Vang T, Reinton NT, Torgersen KM, Hansson V, Jahnsen T (1997) Structure, function, and regulation of human cAMP-dependent protein kinases. Adv Second Messenger Phosphoprotein Res 31:191–204

    PubMed  CAS  Google Scholar 

  • Taylor A, Mamelak M, Reaven E, Maffly R (1973) Vasopressin:possible role of microtubules and microfilaments in its action. Science 181:347–350

    PubMed  CAS  Google Scholar 

  • Taylor SS, Buechler JA, Yonemoto W (1990) cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Ann Rev Biochem 59:971–1005

    PubMed  CAS  Google Scholar 

  • Teitelbaum I (1991) Vasopressin-stimulated phosphoinositide hydrolysis in cultured rat inner medullary collecting duct cells is mediated by the oxytocin receptor. J Clin Invest 87:2122–2126

    PubMed  CAS  Google Scholar 

  • Teitelbaum L, McGuinnes S (1995) Vasopressin resistance in chronic renal failure. Evidence for the role of decreased V2 receptor mRNA. J Clin Invest 96:378–385

    PubMed  CAS  Google Scholar 

  • Terris J, Ecelbarger CA, Marples D, Knepper MA, Nielsen S (1995) Distribution of aquaporin-4 water channel expression within the rat kidney. Am J Physiol 269:F775–F785

    PubMed  CAS  Google Scholar 

  • Tsukita S, Yonemura S, Tsukita S (1997) ERM proteins:head to tail regulation of actin-plasma membrane interaction. TIBS 22:53–58

    PubMed  CAS  Google Scholar 

  • Tuvim MJ, Adachi R, Chocano JF, Moore RH, Lampert RM, Zera E, Romero E, Knoll BJ, Dickley BF (1999) Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis. Am J Respir Cell Mol Biol 20:79–89

    PubMed  CAS  Google Scholar 

  • Ungermann C, Nichols BJ, Pelham HRB, Wickner W (1998a) A vacuolar v-t-SNARE complex, the predominant form in vivo and on isolated organelles, is disassembled and activated for docking and fusion. J Cell Biol 140:61–69

    PubMed  CAS  Google Scholar 

  • Ungermann C, Sato K, Wickner W (1998b) Defining the function of trans-SNARE pairs. Nature 396:543–548

    PubMed  CAS  Google Scholar 

  • Vajanaphanich M, Schultz C, Tsien RY, Traynor-Kaplan AE, Pandol SJ, Barret KE (1995) Cross-talk between calcium and cAMP-dependent intracellular signaling pathways. J Clin Invest 96:386–393

    PubMed  CAS  Google Scholar 

  • Valenti G, Frigeri A, Ronco PM, D’Ettorre C, Svelto M (1996) Expression and functional analysis of water channels in a stably AQP2-transfected human collecting duct cell line. J Biol Chem 271:24365–24370; Correction (1997) J Biol Chem 272:26794

    PubMed  CAS  Google Scholar 

  • Valenti G, Procino G, Liebenhoff U, Frigeri A, Benedetti PA, Ahnert-Hilger G, Nürnberg B, Svelto M, Rosenthal W (1998) A heterotrimeric G protein of the Gi family is required for cAMP-triggered trafficking of aquaporin 2 in kidney epithelial cells. J Biol Chem 273:22627–22634

    PubMed  CAS  Google Scholar 

  • Valentijn JA, Gumkowski FD, Jamieson JD (1996) The expression pattern of rab3D in the developing rat exocrine pancreas coincides with the acquisition of regulated exocytosis. Eur J Cell Biol 71:129–136

    PubMed  CAS  Google Scholar 

  • Valtin H (1976) Animal model of human disease:hereditary hypothalamic diabetes insipidus. Am J Pathol 83:633–636

    PubMed  CAS  Google Scholar 

  • Valtin H (1992) Genetic models of diabetes insipidus. In: Handbook of Physiology. Renal Physiology. Bethesda, MD. Am Physiol Soc sec 8 vol 2:1281–1315

    Google Scholar 

  • Van Aelst L, D’Souza-Schorey C. (1997) Rho GTPases and signaling networks. Genes Dev 11:2295–322

    PubMed  Google Scholar 

  • Vaughan M (1998) Signaling by heterotrimeric G proteins minireview series. J Biol Chem 273:667–668

    PubMed  CAS  Google Scholar 

  • Verkman AS, Lencer WI, Brown D, and Ausiello DA (1988) Endosomes from kidney collecting tubule cells contain the vasopressin-sensitive water channel. Nature 333:268–269

    PubMed  CAS  Google Scholar 

  • Verkman AS, Weyer P, Brown D, Ausiello DA (1989) Functional water channels are present in clathrin-coated vesicles from bovine kidney but not from brain. J Biol Chem 264:20608–20613

    PubMed  CAS  Google Scholar 

  • Verkman AS (1992) Water channels in cell membranes. Annu Rev Physiol 54:97–108

    PubMed  CAS  Google Scholar 

  • Vijayaraghavan S, Goueli SA, Davey MP, Carr DW (1997) Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J Biol Chem 272:4747–4752

    PubMed  CAS  Google Scholar 

  • Vischer UM, Wollheim CB (1998) Purine nucleotides induce regulated secretion of von Willebrand factor:involvement of cytosolic Ca2+ and cyclic adenosine monophosphate-dependent signalling in endothelial exocytosis. Blood 91:118–127

    PubMed  CAS  Google Scholar 

  • Vischer UM, Lang U, Wollheim CB (1998) Autocrine regulation of endothelial exocytosis:von Willebrand factor release is induced by prostacylin in cultured endothelial cells. FEBS Lett 424:211–215

    PubMed  CAS  Google Scholar 

  • Vitale N, Mukai H, Rouot B, Thiersé D, Aunis D, Bader M-F (1993) Exocytosis in chromaffin cells. J Biol Chem 268:14715–14723

    PubMed  CAS  Google Scholar 

  • Von Gersdorff H, Matthews G (1999) Electrophysiology of synaptic vesicle cycling. Annu Rev Phsyiol 61:725–52

    Google Scholar 

  • Wade JB, Stetson DL, Lewis SA (1981) ADH action:evidence for membrane shuttle mechanism. Ann NY Acad Sci 372:106–117

    PubMed  CAS  Google Scholar 

  • Wade JB (1994) Role of membrane traffic in water and Na responses to vasopressin. Semin Nephrol. 14:322–332

    PubMed  CAS  Google Scholar 

  • Wagner C, Kurtz A (1998) Regulation of renin release. Curr Opin Nephrol Hypertens 7:437–441

    PubMed  CAS  Google Scholar 

  • Wang G, Witkin JW, Hao G, Bankaitis VA, Scherer PE, Baldini G (1997) Syndet is a novel SNAP-25 releted protein expressed in many tissues. J Cell Sci 110:505–513

    PubMed  CAS  Google Scholar 

  • Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof TC (1997) RIM is a putative Rab3 effector in regulating synaptic-vesicle fusion. Nature 388:593–598

    PubMed  CAS  Google Scholar 

  • Weber E, Berta G, Tousson A, St John P, Green MW, Gopalokrishnan U, Jilling T, Sorcher EJ, Elton TS, Abrahamson DR, Kirk KL (1994) Expression and polarized targeting of a rab3 isoform in epithelial cells. J Cell Biol 125:583–594

    PubMed  CAS  Google Scholar 

  • Weber T, Zemelman BV, McNew JA, Westermann B, Gmachl M, Parlati F, Söllner TH, Rothman JE (1998) SNAREpins:minimal machinery for membrane fusion. Cell 92:759–772

    PubMed  CAS  Google Scholar 

  • Wollheim CB, Lang J, Regazzi R (1996) The exocytotic process of insulin secretion and its regulation by Ca2+ and G proteins. Diabetes Rev 4:276–297

    Google Scholar 

  • Wonerow P, Schöneberg T, Schultz G, Gudermann T, Paschke R (1998) Deletions in the third intracellular loop of the thyrotropin receptor. A new mechanism for constitutive activation. J Biol Chem 273:7900–7905

    PubMed  CAS  Google Scholar 

  • Xu DL, Martin PY, Ohara M, StJohn J, Pattison T, Meng X, Morris K, Kim JK, Schrier RW (1997) Upregulation of aquaporin-2 water channel expression in chronic heart failiure rat. J Clin Invest 99:1500–1505

    PubMed  CAS  Google Scholar 

  • Yamaguchi T, Yamamoto A, Furuno A, Hatsuzawa K, Tani K, Himeno M, Tagaya M (1997) Possible involvement of heterotrimeric G proteins in the organization of the Golgi apparatus. J Biol Chem 272:25260–25266

    PubMed  CAS  Google Scholar 

  • Yamaki M, Kusano E, Tetsuka T, Takeda S, Homma S, Murayama N, Asano Y (1991) Cellular mechanisms of lithium-induced nephrogenic diabetes insipidus in rats. Am J Physiol 261:F505–F511

    PubMed  CAS  Google Scholar 

  • Yamaki M, McIntyre S, Rassier ME, Schwartz JH, Dousa TP (1992) Cyclic-3′,5′-nucleotide diesterases in dynamics of cAMP and cGMP in rat collecting duct cells. Am J Physiol 262:F957–F964

    PubMed  CAS  Google Scholar 

  • Yang B, Gonzaler Jr L, Prekeris R, Steegmaier M, Advani RJ, Scheller RH (1999) SNARE interactions are not selective. J Biol Chem 274:5649–5653

    PubMed  CAS  Google Scholar 

  • Yasui M, Zelenin SM, Celsi G, Aperia A (1997) Adenylate cyclase-coupled vasopressin receptor activated AQP2 promoter via a dual effect on CRE and AP1 elements. Am J Physiol 272:F443–F450

    PubMed  CAS  Google Scholar 

  • Yasui M, Kwon TH, Knepper MA, Nielsen S, Agre P (1999) Aquaporin-6:An intracellular vesicle water channel protein in renal epithelia. Proc Natl Acad Sci USA 96:5808–5813

    PubMed  CAS  Google Scholar 

  • Zeidel ML, Hammond T, Bothelo B, Harris Jr HW (1992) Functional and structural characterization of endosomes from toad bladder epithelial cells. Am J Physiol 263:F62–F76

    PubMed  CAS  Google Scholar 

  • Zhu X, Gilbert S, Birnbaumer M, Birnbaumer L (1994) Dual signaling potential is common among Gs-coupled receptors and dependent on receptor density. Mol Pharmacol: 460–469

    Google Scholar 

  • Zussman A, Hermuet S, Sagi-Eisenberg R (1998) Stimulation of Ca2+-dependent exocytosis and arachidonic acid release in cultured mast cells (RBL-2H3) by a GTPase-deficient mutant of G alpha i3. Eur J Biochem 258:144–149

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Forschungsinstitut für Molekulare Pharmakologie, Alfred-Kowalke-Straße 4, D-10315, Berlin, Germany

    E. Klussmann, K. Maric & W. Rosenthal

  2. Institut für Pharmakologie, Freie Universität Berlin, Thielallee 67-73, D-14195, Berlin, Germany

    W. Rosenthal

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  1. E. Klussmann
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  2. K. Maric
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  3. W. Rosenthal
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Klussmann, E., Maric, K., Rosenthal, W. (2000). The mechanisms of aquaporin control in the renal collecting duct. In: Reviews of Physiology Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0119577

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  • DOI: https://doi.org/10.1007/BFb0119577

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