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Alterations in the expression of signal-transducing CD3ζ chain in T cells from patients with chronic inflammatory/autoimmune diseases

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

The CD3ζ chain, a component of the T cell receptor (TCR)/CD3 complex, is considered to be a limiting factor in the assembly and transport of the TCR/CD3 complex to the cell surface and is crucial to receptor signaling function. Recent studies have demonstrated altered expression and function of this signal transduction molecule in T and natural killer cells in patients with chronic inflammatory/autoimmune diseases. In this review, current knowledge concerning the expression of CD3ζ chain as well as the mechanisms responsible for abnormal expression of this molecule in systemic lupus erythematosus, rheumatoid arthritis, and childhood idiopathic nephrotic syndrome are summarized.

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Authors and Affiliations

  1. Laboratory of Immunopathology, Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, R. Weigla 12, 53-114, Wrocław, Poland

    Lidia Ciszak, Edyta Pawlak, Agata Kosmaczewska & Irena Frydecka

  2. Department of Hematology, Wrocław Medical University, Wrocław, Poland

    Stanisław Potoczek & Irena Frydecka

Authors
  1. Lidia Ciszak
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  2. Edyta Pawlak
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  3. Agata Kosmaczewska
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  4. Stanisław Potoczek
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  5. Irena Frydecka
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Corresponding author

Correspondence to Lidia Ciszak.

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Ciszak, L., Pawlak, E., Kosmaczewska, A. et al. Alterations in the expression of signal-transducing CD3ζ chain in T cells from patients with chronic inflammatory/autoimmune diseases. Arch. Immunol. Ther. Exp. 55, 373–386 (2007). https://doi.org/10.1007/s00005-007-0042-6

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  • DOI: https://doi.org/10.1007/s00005-007-0042-6

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