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Sjögren’s syndrome: An old tale with a new twist

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Archivum Immunologiae et Therapiae Experimentalis Aims and scope

Abstract

Sjögren’s syndrome (SjS) is chronic autoimmune disease manifested by the loss of saliva and/or tear secretion by salivary and/or lacrimal glands, respectively. The pathogenesis of the disease remains elusive, perhaps due to the multiple triggers of the disease. However, substantial advances have been made in attempting to resolve the complexity of SjS using both animal models and human subjects. The primary objectives of this review are to provide a better understanding of the disease processes with major emphasis on the use of mouse models, how genetic predisposition plays a role in the natural history of the disease, as well as a presentation of new findings pertaining to the role of TH1, TH2, and TH17 cells in the pathogenesis of SjS.

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  1. Department of Oral Biology, College of Dentistry, University of Florida, PO Box 100424, Gainesville, FL, 32610, USA

    Byung Ha Lee, Mauro A. Tudares & Cuong Q. Nguyen

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  1. Byung Ha Lee
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  2. Mauro A. Tudares
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  3. Cuong Q. Nguyen
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Correspondence to Cuong Q. Nguyen.

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Lee, B.H., Tudares, M.A. & Nguyen, C.Q. Sjögren’s syndrome: An old tale with a new twist. Arch. Immunol. Ther. Exp. 57, 57–66 (2009). https://doi.org/10.1007/s00005-009-0002-4

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