Abstract
The expression of genes required for progression through the cell cycle is highly modulated through a regulatory axis containing the E2F transcription factor and retinoblastoma tumour suppressor protein families. One of the genes regulated through this mechanism encodes the B-Myb transcription factor, which has been shown to be critically required for early embryonal development in the mouse. Transcriptional activity of B-Myb is substantially enhanced in S phase through modification by cyclin A/cdk2, and the evidence points squarely to the major role being played by B-Myb during this phase of the cell cycle. We discuss in this review recent findings suggesting that B-Myb is a multifunctional protein that has, in addition to its transcriptional properties, the ability to interact directly with other regulators of the cell cycle.
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Received 29 January 2003; received after revision 2 May 2003; accepted 13 May 2003
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Joaquin, M., Watson, R.J. Cell cycle regulation by the B-Myb transcription factor. CMLS, Cell. Mol. Life Sci. 60, 2389–2401 (2003). https://doi.org/10.1007/s00018-003-3037-4
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DOI: https://doi.org/10.1007/s00018-003-3037-4