Abstract.
There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.
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Received 8 July 2004; received after revision 25 August 2004; accepted 17 September 2004
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Katic, M., Kahn, C.R. The role of insulin and IGF-1 signaling in longevity. CMLS, Cell. Mol. Life Sci. 62, 320–343 (2005). https://doi.org/10.1007/s00018-004-4297-y
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DOI: https://doi.org/10.1007/s00018-004-4297-y
Key words.
- Aging
- lifespan
- genetic instability
- telomerase
- oxidative stress
- superoxide dismutase
- oxidants
- antioxidants
- reactive oxygen species
- gluthatione
- thioredoxin metabolism
- calorie restriction
- insulin
- IGF-1
- growth hormone
- signaling
- Sir
- FOXO
- p66
- klotho
- animal models
- S. cerevisiae
- C. elegans
- D. melanogaster
- mouse
- knockout
- human
- syndrome
- Ames Dwarf
- Snell Dwarf
- FIRKO