Abstract.
HERC proteins are defined as containing both HECT and RCC1-like domains in their amino acid sequences. Six HERC genes have turned up in the human genome which encode two different sorts of polypeptides: while the small HERC proteins possess little more than the two aforementioned domains, the large ones are giant proteins with a plethora of potentially important regions. It is now almost 10 years since the discovery of the first family member and information is starting to accumulate pointing to a general role for these proteins as ubiquitin ligases involved in membrane-trafficking events. In this review, the available data on these six members are discussed, together with an account of their evolution.
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Received 16 March 2005; received after revision 13 April 2005; accepted 28 April 2005
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Garcia-Gonzalo, F.R., Rosa, J.L. The HERC proteins: functional and evolutionary insights. CMLS, Cell. Mol. Life Sci. 62, 1826–1838 (2005). https://doi.org/10.1007/s00018-005-5119-y
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DOI: https://doi.org/10.1007/s00018-005-5119-y